Caution, this is an AI generated summary based on literature. This may have errors, see here for more.
Please share your feedback with us.
MIR1915: The interaction between POU5F1, HNF1A, and MIR1915 was examined, and it was found that MIR1915 significantly suppressed the expression of HNF1A [PMC8121855]. MIR1915 was also shown to improve drug sensitivity and suppress HNF1A expression in persister cells compared to a negative control [PMC8121855]. MIR1915 has been identified as a top-ranked microRNA and its downregulation has been observed in plasma samples from patients with chemoresistant colorectal cancer (CRC) [PMC8121855]. In CRC cell lines, MIR1915 reduced HNF1A mRNA expression and improved drug sensitivity, particularly for oxaliplatin, CPT-11, and 5-FU [PMC8121855]. The regulation of HNF1A gene expression by MIR1915 was confirmed through reporter assays [PMC8121855]. Additionally, the suppression of HNF1A using MIR1915 improved chemosensitivity in primary cultured cells exposed to anti-cancer agents [PMC8121855].
Genome locations
Gene Ontology annotations
Ancestor Chart
Loading ontology ancestors...
Failed to load QuickGO Ancestor chart
Sequence
Sequence features are shown above as colored rectangles.
Zoom in and click to view details, or
Reset
