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Homo sapiens (human) USP3 antisense RNA 1 (USP3-AS1) URS000075C5F6_9606

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USP3-AS1: USP3-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases. It has been shown that knockdown of USP3-AS1 enhances sensitivity to Paclitaxel and Doxorubicin in triple-negative breast cancer (TNBC) by altering the expression of several lncRNAs, including LINC-PINT, NEAT1, and USP3-AS1 itself, as well as suppressing various genes involved in cancer progression [PMC9576993]. USP3-AS1 has also been found to be significantly downregulated following exposure to electronic cigarettes [PMC8643021]. However, the functional analysis of USP3-AS1 in cancer has not been reported [PMC6920248]. In neuroblastoma samples, USP3-AS1 was found to be significantly downregulated compared to normal samples [PMC6920248]. It has also been identified as a potential biomarker for neuroblastoma pathogenesis studies [PMC7835365]. In pediatric cancer, including neuroblastoma, CASC15, PPP1R26-AS1, and USP3-AS1 have been suggested as putative markers for clinical investigations [PMC7945591]. Overall, these findings highlight the potential importance of USP3-AS1 in cancer biology and its potential as a therapeutic target or biomarker.

Genome locations

Gene Ontology annotations

Sequence

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GGUUGGUGACGCGCGCGCAGUUCUCCAGGCGCAGUGCGCGCAGGCGUGGGCAGCAGCGCAGCAGGCGCGCCAGGCAGUCGUCGGUAACGUGGCCGCAGCCCGAGAGCGUGACGGACGCCAGGUUGGGGCACCUGUGAGGAGAGUGCGGUGACCCGGGGCUCACUGGCUUGUUAAAGCUACCCAACCGCCCCAUGGGACCGAGUGGACUCAUUUACCGAGGAGGACUCGGGCCCUGCGAGGUCACUUCAUCCUGGCCCAGGUACUGCAGCUCCAAAUCGUGGGGAUUCUGUAAGAGCUUGCUACCUGUUGACUGAGGAGGCCCACGAGUUGAGAAGAACUAGCAAGAGUGGUACAAAACUGCAGGUCAUUGGGCUGGCCACCAGGUAUUCCCACCCACCAGAAGCUGGCUGUUGUACUCACCCGGAACCAUGGUGCACCACCACAGCGGCGAGGUCAUACAGGCAGCUCUCCGGGCCACUGUUCUCAGGCUACAGAACAAGGAAGAAGGAGCAGUGGUCAAUGACAUCAGUAUCUCGAUGACCUCUACCCUCUCCAUGUGAUGACAAUCUUACUGAAGAGCCAUUUUUUCACCAUGCUAAAAAGGUAACCACCUUACCUCUAGUAAGUAGCAUUUCAUGUCUAGGCCUCUCAGUGGAAAUUCUACGUAUGUAUCAACUUUAUUUCUUAAAUAUGCUGUCCAAUGAAAUCUUUUCAAAUGUAAGCAUAGCACCUGGAGGACAGAGAUGCGGUCAAAGAUUGUGAACACCUAAUUUACCUUUCAGUCAAAGUUUGAUACUACUAUCAGUUCAGUAAAUAACAUUUUAGCUGCCCUAUCAAUCAUUCUUCCAUGCAUACCUUAUGCAUUCAUUCUGUAAGGGGUUUAGCUUUUACUGAAAAUCCUAGAGAAAAAUACAGAACAGUUCACAUAGUGUAAAGUUAUAGACAUGGUCUUAGCAGUCAAGCACUUUCCCAUUGAAAUUGCUUCAUAACUCAAAAUUCAACACUCACCUUGGGUAGUUUUUGAAUCCAAAACUUUUUUGUGGACUUUUGUUUCUUUUUGCAUUUAUGGCACAUAUAUAACUCUGUCUCAUCAAGUUCUUCUAAGUCGGUAAAACUGCGAAGACAAUCUAAACAAAUUGAUUUUGGCAGCAUUAAAACAAGAUGCCUUUUGUAGAGGCAAUGUACUGUAGAAAAAAGACCCAGGUUUAAAAUCUCAGCUUUAUUAGCUAUACGACCUUAGAAAAGUUAACCUUUCUCAAUUGCAAACUGGAGACAAAAAAUAAUACCUACUUUGAAGAACUAUUAUAAGGAAGAGAAAUAAUGUGUAGAGCACCUGGCAUCAUGCCUGACAUCUGGUGAUGAUCAAUUGUGUUGGUUUUACUAUUAAUGAUAAUUCAUCUGGAUAAUUCUGAUAAAAUGGUUUCCUGAUGAAUUUAAAGUUUCAAUUGUAGUUUUCUGUCAAUAUGUUACAUUAUACAGGACAAAGCUCCAAACUCAUAAAAAAAAGUCAAAUUUAGAUAAUUUAAAAAUAAACAUAGAUCACAGAAGGCUACACUAUCAACCUUCUCUGUCCAGACGCUGUACUCUCAGUUCCUAGAUAAAUCACAGCUACAUUUUUUUUCAUUUAAAGAUGUAAUUGUGUAACCUGGGGUUUAGUAAACUACAGUCCUAAAACAUCCAGCCAGCCACCUGGUUUUGUAAAUAAAGUUUCAUUGGAACAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications