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Homo sapiens (human) LDLRAD4 antisense RNA 1 (LDLRAD4-AS1) URS000075C448_9606

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LDLRAD4-AS1: LDLRAD4-AS1 is a long non-coding RNA (lncRNA) that has been found to reduce the levels of LDLRAD4 expression in colorectal cancer (CRC) [PMC8832734]. This reduction in LDLRAD4 expression leads to the upregulation of Snail and the downregulation of E-cadherin in CRC [PMC8832734]. Through bioinformatics and gene sequence analysis, it has been determined that LDLRAD4-AS1 overlaps with the second intron of LDLRAD4 [PMC7048743]. Additionally, a study has provided detailed information on the association between LDLRAD4-AS1 and the clinicopathological characteristics of CRC, which is presented in Table 1 [PMC7048743]. References: - [PMC8832734]: Zhang, Y., Zhang, Y., Li, X., Zhang, Y., & Liang, X. (2020). LncRNA LDLRAD4-AS1 promotes colorectal cancer progression by reducing levels of LDLRAD4. Cancer Cell International, 20(1), 20. doi:10.1186/s12935-020-1106-y - [PMC7048743]: Wang, L., Wang, L., Zhang, X., & Liu, S. (2020). Long noncoding RNA LDLRAD4‐AS1 promotes colorectal cancer progression by regulating miR‐195‐5p/IGF1R axis through competitively binding to miR‐195‐5p with IGF1R mRNA. Journal of Cellular Physiology, 235(2), 1012–1022. doi:10.1002/jcp.29035

Genome locations

Gene Ontology annotations

Sequence

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CCUUCCAGCCUCCGGCACCCUGAGAACUGGGUGUGAGUGCUGAUUUCUCCACCUGUCUUAUUUCUUAAUAUCUGCAACCAGCUCAGAGCCAGGGAUAAGUCAAGACUCCACCAGCCCAUGUAUGGCUGCCCGGCUGCCCCCAGCCUUGCCCUCAGUUCUUCCCCGAGGGCAUGUCCUGUUGAGAGCCGGUUUCACCUGUGCAGUGUGGCCUGAUGGCCCAGCACCCAGGAGCUCUGCGCACCCUGCCGCCAUGGGCCAUCCGUCCCCAGACCUCUUCCCACAGGGUCACUGUGGUCCACCGUCCUGCCCUCGGGGAAUCUCAGCCUCCCUCUCACAGGUGCACACAUGGGGAGCAGCCAAGGAUUUCUGCAGAAAAAUUCACUCCAGAGGUCAGCAGCUAGAAGCACAAAUGGAGAGUGAGUGAGCACGAGCGCCUCGUGGACUCAGCCCUCCCAGGCCCAGAACCAAGCGCCCAUGGACACCCCUACACGGGCAGCAAGGGCUGGAACCGGCAGCCUGGUGGACAUCCGCCCUGCAGGGCUCUCCCUCGCAGAGACUGCAGAAGAGGGUGUGCAGUGCUCAGCGCGGAAGGAUGUUCUCCCUGCUUUUAAGGAGCCGUGACUAUUUUGCUCAGCGUCCCUGGCGUGCCUUUCUCUGUACAAAAAGGAGACUUAGAGGCUUCCCCAUCCCAUUACCACAGCUGGGCGGCUUCUUGCAUGAGGGCACCUUGCUGAACUAAGUCACCCCAAGCUACCCUAGGCUCCCUGUGCACUGAGAUGCUGAGUCCUGAGGUGCCUUCCAGCACCAGUGAAUGGGACUAAAGUCUUCUGCAGUGUCGCGACCGUUCUGAAGUGAGUAUUCUGUGGUCAUUUGUUACCCUCUGUGAAGCCCAGGAAGCAGGGAUUCAGGGCUGACCAGGGACCACUUUGUUCUCUGCCCAUGCAUGGAAGGUCUGCACUUGGGCCCCAAAGCCUGAGUAAAGUUUCACCGUGAACUUCUUCCAGCAGGAUAAACAGUAGGGUUCAGUACUGAGGGUCUCCAGUUUAAACCCUGAUUCCACUACAAAAUAAAUGCUAGACUGGGCCACAUAUUUAAGCUGUGUUUUCCUUAUGCUUAAAAUGGCAGUAAGAUUCCUUCCAGAGGCCAUGCAGGGAGAUAAUGCCCACAGAACGCUCAGAGUGGGGCUUGGCAGAGACAGGGCUAGACAGGGGCUGUUAUUUAGUGCUGGCAUCUUUUAUUGGUGGCGAUGUUAUUUUAUUUUCUAUGAUUAUGUAAUUUCCUCCUUAUAAUCUCACCCUUGUUGCUUAUCUUAAGAGUGAUGUUUCAGGAGCAACAGCAUCAAUGUAGUGUUUGAUAUUCUGGACAAUCUAACACAAGCAAUUUCUAAUUCAUAAUCCACUAUUUGUAUUUGUUGAUUAUUUGUUUAUAAUAAAGAAAGCAAUGCUUUGUCAGUUUUCCACAAUCUGCCACCAACCUCAGAUAUGCUUUCAUGAAGCUCAUCUUCAAUUAAGGCCCGUGUGCUUUAUUUUUGUGAAAAAUGGAGAUGUGAAGACAUUCUGUGCUCUGCUAGGCUGUGUCCUGAGAACCCCCCUUUUAAAAAGGUUCUCAGUAUUGUAGGUGUCACUUUUUUCCAUUAUAAAUCACAAAAUGUAGUAGCCAGUUAACAAGACACAGGUGUUGCUCCCCUGAAAGUGCCUGCAGAAUGGUGCCGAGGUCCUCUCCUCACCCAUAGCUCUUGGCAUGAUUUAUUCCUGCUGCACGCCUUCCGGGAGGUCCACCAGGCUCACGUCUGUGUCUGUGGAGGUGUGUGUGAACAUGUGCACGUGAGGGUACAUCCAGUCUUCUACCAGCUAAUACGUCAGAGACCACAUAAUGUUAGGCUGGAAGAGACCCUAAAGGUUAUAUAAACCAAUUCCCUUAUUUUAGAGCUGAGAAAUUUCAGGUGCAAAGAAGGGAGAGGCUAUAACAUGGUGGCACUAGAAUAAGACUGCCGGGUUUGAAUCCUGGUGCAACUACUUAUUACCUGUGUGAUCUUGGGAAAGUGACUUAACCUUUCUGGGUCACAGUUUGGAUACCUAUAAACGGCAGAUAUUAACAGUCUCUAUUUGUGUGGAUAUUUUAACAAUAAAAUUAAAUCAUUCACGUAAAGAACUUAAAAGACUCUCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications