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Homo sapiens (human) long intergenic non-protein coding RNA 619 (LINC00619) URS000075C40C_9606

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LINC00619: LINC00619 is a long non-coding RNA (lncRNA) that has been studied in relation to osteosarcoma (OS) and gastric cancer (GC). In OS, LINC00619 overexpression promotes apoptosis of OS cells by targeting hepatocyte growth factor (HGF) and downregulating AKT mRNA expressions and its protein phosphorylation [PMC9563963]. It has been found that LINC00619 is downregulated in OS cells, associated with AKT mRNA overexpression and its protein phosphorylation [PMC9563963]. Additionally, the PI3K/Akt pathway and HGF expression were repressed in OS cells overexpressing LINC00619 [PMC9885180]. In GC, LINC00619 is associated with miR-224-5p and OPCML protein. Decreased expression of both LINC00619 and OPCML in GC tissues, along with increased miR-224-5p expression, leads to the induction of cell proliferation, invasion, migration, and inhibition of apoptosis [PMC9813052]. Furthermore, a lower expression of LINC00619 has been observed in GC tissues compared to normal tissues [PMC9813052]. The prediction ability of a six-lncRNA signature that includes LINC00619 for survival was found to be higher than that of the FIGO staging in OS patients [PMC8457683]. Overall, these findings suggest that LINC00619 plays a role in regulating cell processes such as apoptosis and proliferation in both OS and GC.

Genome locations

Gene Ontology annotations

Sequence

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AGAUGCCAUGAGUCCAAAGGAAUCAUCCCGCCCCCAGCAGACAAGCGUGGAGCCAGCCUGCUCCUCUGGCCAAAGCAUUCCACCCCCGGACCUCUCCUCCAGGAAGAAGAGAUGUGGAAGAAGAGAUGUGGGUAUGGUGGAUUCUGACCCUUGGCUCCCCAAAGUUCCACAGAGCCCAGCUCCCACUGAAGGCAUAUGACCCAGAUCCUGAGAACCAGAUGCACCGGCCUGAGCUUUCGUCAGAAGCAAGGACACACAGAACCUUUCUUAGAGGCAUCAUUAGAGGACCGGACAUGGUGGCCAGAGGCUGCAGGGACAGAAGUCCCAGGGCCAUGUCCAGGAACUGGGCUCAGGGGACCUCCUGGUGCCACCUGCAUAUCUGAGCCCAUGGAGUUCCUCUGGUCUAUUCAGUUCUCUCAUUUUAACUUAAUUUUGUUUUUGUAGGCUUUCUUAAAAAAUUGCCCAGUUCAUUUACCUGAUCACGUUUAUUGUUCAGAGUUGAGUGUGGUUCUCUCGUAAUUAUUUAGUCUCCACUGGGUCUGUGAUUAUAUUUCCUUUCUUAUUGCUAAUGCUGUUUGUGUUUGAUUUUCUUCUUUUUUUUCUUGGCCUGACUUAAAGAGGUUUGUCUGUUUUAUCUUUAUUUUAAAAAUAACCAACUGUUUAUUUUUACUUCUCCACUGUGAUUUCCCCCUUUAUUUCUUUAAUGUUUGAGUUUAUAUUUUUUCCUAUUUAUUUUGGCUUAAAUUUUAUUAUCAUUUUGCUAUAUCCUUGUGUCAAGCGCUUAAUUCAAUUAUUUUGUUAUUUUGACUUCUAAAAAAUCAGUUAAUUCUAUAAGUUUUCCUCUAUGUACUACAUUGAGCAAACUCCACAGAUUUCUGUAGGGGGCAUACUAAUUGUAAUUCAAUUUCGUUUUCCAUGUGUAGGUCCAGAUUUAUUUGAAUGUCCAAAUACUUAGAAUUGUAGGCUCUUGUUUUGUUAUUAAAGUCUGGUUUUAUUACAUUGUGUUUAGAGAAAAUAAUAUGGAGGAUUUUAAUUUUAGAUAAAGCAUUAAUAUCUUUUUUAUCCUCAAACAUGAUCAAUUUUUGACAGUGUUCCAAAAAUAUACUAUGAAAUAUAUAUUAAAAAAAAAAA

Taxonomic tree

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Publications