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Homo sapiens (human) GLIS2 antisense RNA 1 (GLIS2-AS1) URS000075C229_9606

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GLIS2-AS1: GLIS2-AS1 is a long non-coding RNA (lncRNA) that has been studied in relation to lung adenocarcinoma (LUAD) and parathyroid carcinoma (PC). In LUAD, GLIS2-AS1 exhibited a lower expression in tumor tissues compared to normal tissues, and it was considered to be closely related to LUAD prognosis [PMC10061461]. It was also identified as a low-risk factor and confirmed to be underexpressed in LUAD [PMC10061461]. In PC, GLIS2-AS1 showed lower expression compared to parathyroid carcinoma samples without CDC73 mutation, suggesting an association with changes in lncRNAs related to the CDC73 gene [PMC9140881]. GLIS2-AS1 was also found to be significantly deregulated in PCs [PMC8508841]. Furthermore, GLIS2-AS1 was identified as one of the transcripts selectively detected in uterine fibroid-derived extracellular vesicles from women with successful implantation and pregnancy [PMC8289330]. However, there is currently no available study on the role of GLIS2-AS1 in cancer [PMC8540444]. Overall, these findings suggest that GLIS2-AS1 may have potential as a prognostic marker for LUAD and PC, as well as a marker for successful pregnancy.

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Gene Ontology annotations

Sequence

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GCGAGAGCUAGGUUCCUGCUCUCCUGAAAGCCUCGGAGGCCCAGAGCGGGGAGCAGCGGGCCUGCAACCAGGGAACCCUGAAAGGAAGCGGGUCCUCUGUAAGAUGGGGCUGCAUCCCUGCCCCGCUCCCAGCAGCAUGGGGUCAGAUGCAAAAACUGAGGCUCAGGGGAGUGAAGUGACCCAUCCAAGGUCCCACAGCUUGUCCGUGGCAGAGCUGGGUUUCAACCCCAGGGAGAAACCAAUGCAGUGCUGCACAUCCAAUCACUAUUGAGUGCUUCUCCUUCGUCCGUAACGUUCAGCACGGAGAACAGUGCCUGGCACAUAGUAGGUGCUUAAUAAAACGUGCUGAAUGAAUCGUC

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