v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) lncRNA neighboring enhancer of FOXA2 (LNCNEF) URS000075C152_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

LNCNEF: LNCNEF is a long non-coding RNA (lncRNA) that has not been extensively studied in non-small cell lung cancer (NSCLC) [PMC9781688]. The protein-coding gene for FOXA2 is located on chromosome 20, p11.21, between the lncRNA LINC00261 and LNCNEF [PMC9781688]. In a study on thyroid cancer, the expression levels of MPPED2-AS1, LNCNEF, and LOC100129129 were found to be significantly reduced in malignant nodules compared to benign nodules and normal thyroid tissues [PMC9483125]. The diagnostic potential of several lncRNAs, including LNCNEF, was analyzed using receiver operating characteristic (ROC) curves in the TANRIC thyroid cancer dataset. The expression levels of LRRC52-AS1, LINC02082, UNC5B-AS1, MPPED2-AS1, LNCNEF, and LOC100129129 were found to be significantly increased or decreased in malignant nodules compared to normal thyroid tissues and benign nodules. This suggests that these lncRNAs could be used for differentiating between benign and malignant tumors in thyroid nodules [PMC9483125]. In vitro overexpression of LNCNEF resulted in a reduction in migration and invasion capacities of small cell lung cancer (SCLC) cells through TGF-β1 downregulation. However, LNCNEF was downregulated in SCLC patients and its expression in plasma was associated with distant tumor metastasis [PMC9685014].

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
AUGAAGAAACAGAGGGAUAUACUGCCGUCUUAAACCAACCCAAAUGCCUCUGCCGCAGUCGCAGUUAUUUAGGGUGGAGAAGCGGGCUCUGGCAACUAGAGAAGGUGGCCGCAGCAUGGGGACACCCGAAUUGAGGAGCUGUUUGGGCAAUAAGCUGAUUUAGAGAAUUAAGACCUCCACAGAUGGGAGUGGAAUCCGCAACUGCUCAAUCCAUCCACUGAGAAGUCCCAUAAAAGAUGGACAAUCCAUAACUGAAACCCAACCUUCGGCACAACGAUCAAAUUCUACAUGCAUAAAGCAAGAGAUCUGUGUGCCAGAUCCAUCUUAAAGGCACCCCACCCAGAGGACAGAGUCUGUCUCCUUCCCCUAAACAAUAUGCAGAAACCACCCUGGUAUUUCAUGGGUUCUCACUUAGGAAAAUUGAGUUCUGUUCAAUGAUGCCCCUUCUGCACUGGUUGGUUUCAUGUGACAAAGAGAGCUCUAGGGAGGACUUUUGCUAGGGGAACGCAGAUUGUUCCAGCAAGAUGAAGGCCUAGGAGACCUGGAUGGCCUGGGUGUUUUCUUCCCAGGGAGAGCAGAGGAGGCCUGGAUUUGAACUCGAGUCUUAUGACUUUGCCAUUGAGGCAACAUCCAAAAUAAAAAUAGCAUGCUAACCCCAAAAAAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications