MIR1908: MIR1908 is a microRNA encoded by the MIR1908 gene on the minus strand of chromosome 11 [PMC9469614]. Previous studies have shown that MIR1908 is associated with poor prognosis in ovarian cancer, as its target gene SIRT2 is linked to poor prognosis [PMC8320514]. It has been suggested that MIR1908-3p, rather than MIR1908-5p, may drive AKT activation [PMC8660805]. AMPK activity has been shown to contribute to the maintenance of MIR1908 expression [PMC8660805]. The activation status of AKT in response to MIR1908 targeting has been examined, as the PI3K/AKT/mTOR axis is frequently activated in cancer cells [PMC8660805]. The production of MIR1908-5p may require ongoing glycolysis [PMC8660805]. However, in neuronal models, overexpression of MIR1908 was shown to activate AKT [PMC8660805]. The expression of FADS1 and FADS2, which are related to MIR1908, was found to be largely insensitive to glucose concentration [PMC8660805]. The regulation of the MIR1908 and FADS1/2 loci appears to be independent based on prior evidence [PMC8660805]. MIR1908 has also been investigated in prostate cancer. It was found that MIR1908 showed a lower expression mode in tumor tissues compared to normal tissues and may serve as a potential biomarker for prostate cancer patients along with other genes such as SPOCK3 and SPON1 [PMC5696163]. Furthermore, studies have examined the association between genetic variants in miRNA coding genes and bipolar disorder (BD). It was found that variants in miRNA coding genes such as MIR499A, MIR708, and especially MIR1908, were significantly associated with BD [PMC9547016]. Functional analyses were performed to determine the impact of these variants on the secondary structure of the respective miRNAs [PMC9547016].