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Homo sapiens (human) long intergenic non-protein coding RNA 839 (LINC00839) URS000075BFEF_9606

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LINC00839: LINC00839 is a long non-coding RNA (lncRNA) that has been implicated in various cancer types. In neuroblastoma, inhibiting LINC00839 has been suggested to have an anti-tumor effect [PMC8232867]. In breast cancer, LINC00839 expression is activated by the Myc oncogene and has been shown to promote proliferation and chemoresistance [PMC8473733]. This effect is mediated through the binding of LINC00839 with Lin28B and subsequent activation of the PI3K/AKT signaling pathway [PMC8473733]. LncRNAs, such as LINC00839, have emerged as important regulators of gene expression and cellular processes in cancer. They can interact with proteins and other RNA molecules to modulate gene expression networks [PMC8232867]. In neuroblastoma, inhibiting LINC00839 may have therapeutic potential by suppressing tumor growth or enhancing sensitivity to treatment [PMC8232867]. In breast cancer, the activation of LINC00839 by Myc suggests a potential role in oncogenesis. The binding of LINC00839 with Lin28B further enhances its oncogenic properties by activating the PI3K/AKT signaling pathway [PMC8473733]. This pathway is known to promote cell proliferation and survival, as well as confer resistance to chemotherapy [PMC8473733]. Understanding the molecular mechanisms underlying the role of LINC00839 in neuroblastoma and breast cancer could provide insights into potential therapeutic strategies targeting this lncRNA. Further research is needed to elucidate its precise functions and explore its clinical implications in these malignancies.

Genome locations

Gene Ontology annotations

Sequence

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GAUAUCUAGUUAAAUAAGUCAUUAUAAAUAGUUGCUCCGUGGGCUUUCCGCAUUUCACCCUGCUCCAGGCAGCGUGGUCUGUAUGGCUCCGCCCUGGGCAGGAGGAGAAAGAAGAGGGCCAGGCACCACGUGCCUGCACUCUCCCUGGAUGCUGGAGGCUGCUCCGCCGUGGGCAGGAGGAGAAGGAAGAGAACUGGGUGCCGCCUGCCUGCACUCUCUCCGGAUGCUGGAGGCUGGAGGCAGUGAGGCAGCAACAGCGCGAGGGCGAGGCGACUUUGGAGCUGCCUCAUGCAGCGACCUCGCCUUCCGCUGCGCCUCCUCCCAGAACCCAAGAAGCCUGGAACCUGUGGCGUCCAGCCCUGAAAGGAGGAGACGGCAACCCAGCCGCGCUUUUGCCUGCACUCUCCCUGGAUGCUGGAGGCUGGAGGCAGUGACGCAGCAACAGCGCGAGGCGACUUUGGAGCGGCCUCAUAUAGCGACCUCGCCUUCCGCUGCGCGUCCUCCCAGAGCCCAAGAAGCCCGGAACCUGUGGCAUCCAUCUCUGAAAGGAGAAGACGGCAACCCAGCCGAGGCACUACUGGGUUGGGGUCUCCACGACCGAGCUGGUCUCAUCAAGUGGCGUCCAACAAGGGGCUCAAACCCGGGUUGAGGGGUUGCUGGAGCGACGGAGAACGUGGAACUACACUGGAGGACACCAGAGUACUCUUAAGCAAUCCCUUGGCCAAAACCAGCAACUGAUUUGGAUACCAUCAAGACACCUGAAAUCUUGUCAUGAGCCAGAUACUGAGGAAGAGAUUUUGGGAAGAACCCAAGGACCCCCCAGUUGCAGCCAUGUCAAGACUGACAAUAAGGAAGACAUCAGUCCCAGCAAGCAACAUUCAUCGGGCACAGCCACCCAUGUGGGGCCAGAUCAAGAAGUUGACACAGAUGGCGGAAGAAAAUCUGAAGAAAGCGGAUGACCAGCUACAAUGAGUAAUCUAAUGUCUGCAGAUGUGGAUCCCGAAUCCUGCGAGAAGUAGCCCACCAUGACGAAGCUGCCUUUGCUUUUAUCGCUUUGCAAAAACAGAAAAGGGGACAUGCUGGGAACAGGCCCUAAGCCUGUCAUAAACAGGCCUUAAACUGACCAUGAACAGGAUUUCUGCACGAAUGUGACGUGCUCCUGAUGGCUAUGACGCCCACUGCUAGAAGUUGUUAGUUUACUGGAGCAGGGUAGGGAACACCUGGCCCACCCGGAGCGGAAAACUGCUCAAACCACAAACAACAGCAUGAGUGGCCUGAGCCUUAACAACAUGUUUUUGCUGCAGAUAAUCGGCCAGAGACUGUUUCUCUACUCCUCUCUAAGUAUGCUUUGUUUUUCGUAAGGAAUGCUUUUAGCUAAUCUGUAACCUAUAGAAACAAUGCUUAUCACUGGCUUGCUGUCAAUAAACAUGUGGGUCAAACUCUGUUUGUGGCUCUCAGCUCUCAAGGCUGUUUUCCCCCUGAUUCCCACUUUGCACUUUAUUUCUGUGUGUUUGUCUUCAUUCCUCUAGCACCACUGGGUUGGGGUCUCCUUGACCAAGCUGGUCUCGGCACAUAUGCAUGUAUGCCCAGGUCCUGAAAUCAGCCUUGUGGAGCCUGUGGGUAGGAAAAGUCAACCCUCUGUGCAUGUAGGCCUGGAACCUGACCAAUACUGUAUUUUCCUACCACGUUUGGUUUCAAAUGUGGAAACUGCCCAUACGGACCUACUGCAUUUGUUUUUAAAAAUCCUCUGUAAGUGGACCUGCACAGUUCAGGCCCAGAUUGUUCCAGGAUCAACCCUACAGUAGAAAUCAAGUAUCUUUUUCAUUGUCUCUUGGGAUCUGCCUUUUCACCAAUAAAAUAUGAGGGCUGUUGGGAGCAGGCCCCCCCAAAUCUGGCCAUAAACUGUCCCCAAAACUGGCCAUAAACAAAAUCUCUGCAGCACUAUAACAUGUUCAUAAUGGCCAUAACGCCCAAGUUGGAAGGUUGUGGAUUUACAGGAAUGAGGGCAAGGAACACCUGGCCUGCCCAGGGUGGAAAACCACUUAAAGGCAUUCUUAAGCCACAAACAAUAGCAUGAGUGAUCUGUGCCUUAAGAACAUGCUCCUGCUGCAGUUAACUAGCCCAACAUAUUCCUUUAAUUCAGUCCAUCCCUUCGUUUCCCAUAAGGGAUACUUUUAGUUAAUUUAAUAUCUAUAGAAAGAAUGCUAAUGACUGGUUUGCUGUUAAUAAAUACGUGGGUAAAUCUCUGUUUGGGGCUCUCAACUCUGAAGGCUGUGAGACCCCUGAUUUCCCACUUGACACCUCUAAAAAAAAAAAAAAAAA

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Publications