MIR374A: MIR374A is a microRNA that has been identified as a direct regulator of the p140Cap protein in lung, gastric, and cutaneous squamous carcinoma cells, linking miRNAs to epithelial cancer cell features through the inhibition of p140Cap expression [PMC5357316]. It is part of a panel of nine miRNAs, including miR-21, miR-218, miR-193b, miR-331, MIR374A, miR548c, miR520f, miR27b and miR-30b that have been associated with tumor volume and shown to have a 67% sensitivity and 80% specificity [PMC9965735]. MIR374A has also been detected in cerebrospinal fluid (CSF) samples from glioblastoma patients and found to correlate with levels detected from tissue biopsies [PMC7014190]. It has been associated with malignancy and identified as an independent predictor for LOFS (loss of fetal signal) when combined with MIR320b [PMC6196565]. In addition to its role in cancer cells, MIR374A has also been implicated in distinguishing hypoxic-ischemic encephalopathy (HIE) patients from healthy newborns and assessing the severity of HIE [PMC7296108]. Furthermore, MIR374A is involved in autophagy regulation by targeting RAB5A and UVRAG genes [PMC4389881]. Overall, MIR374A plays a role in various biological processes including cancer development and progression as well as HIE severity assessment.