v24

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Homo sapiens (human) NRSN2 antisense RNA 1 (NRSN2-AS1) URS000075BD29_9606

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NRSN2-AS1: NRSN2-AS1 is a long non-coding RNA (lncRNA) that has been found to be upregulated in various cancers, including esophageal squamous cell carcinoma (ESCC) and hepatocellular carcinoma (HCC) [PMC9886991] [PMC9929346]. In ESCC, it has been shown that NRSN2-AS1 is transcriptionally regulated by SOX2 and promotes cell proliferation, migration, invasion, and epithelial-mesenchymal transition [PMC9886991]. In HCC, NRSN2-AS1 has been associated with changes in RNA m6A methylation induced by sulfatide and is significantly correlated with immune cell infiltration [PMC9929346]. Additionally, NRSN2-AS1 has been identified as a potential indicator of tumor immune microenvironment (TIME) characterization in HCC [PMC9929346]. The expression of NRSN2-AS1 has also been found to be regulated by m6A modification and correlated with the expression of m6A writer and reader signatures [PMC9929346]. Furthermore, NRSN2-AS1 has been shown to play a tumor-promoting role in ovarian cancer through the miR-744-5p/PRKX axis [PMC10148420]. Overall, NRSN2-AS1 is a newly identified lncRNA that shows potential as a biomarker for cancer progression and immune infiltration in various cancers. Further research is needed to fully understand its role and mechanism in tumor immunity.

Genome locations

Gene Ontology annotations

Sequence

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GGUUGGAGGAAGGGUAGGGGACGCGAGCCUGCUUCCAUCUGACGCUGGACGCUUGUCCCUGCCCCGCGUUGCCUUUUAAAUUUUAGCUCAUUCCGAGACACCUGCCGUCAGACAUUUAUGCAGUGUGUGAUUCUUUCUAAAACAACUCCCUGGAAGAGAGGACAUUUAAUUCAACAAUUUAUUGGCCACCUACUGUGCACCAGGCAGUGAACUUGGAACUGGGGCUACUGGGUUACAGCAGUGACCAAGACAGAGGUCCCUGUUCUUAAGGAGCAAGUGAGGGCAACAGAAAAGAGCAGUCAGCUGUCAUGCGAGGGCACUCAAGCAGCCCUGUGGAAAGCUCUACGUGGUGAGAAACUGAAGCCUCCUGCCAACACCAACAAGGAACUGAGACCUACUUCCAACAGCCAUCUGAGUGAUCGAUCCAUCCUGGAAUCAGAUCCUCCAGCCCCAGUCAAGUCUUCAGAUGACUGCAGCCCUGACCAGCAUCUCAACUGCAACCUCGUGAAUGACCCUGAGCCAGAACCAUGCAACUAAACUCUGCGUGGAUUCAUGACCCACAGAAACUGUGAGAUGGUAGCUGUUUGCUUUGUUAAGCCUCUAAGUCUGGAAAGAAUGUCUUAAGCAGUAGCAGACAAUGAACACAAGAUUAUUAUUCAGCUGUUGAAUUGGAAGAGGAGGGGAAGAAAAAAUUUUCAGAUCACAAAAUAUUCAUUGUGUAAAACUUCAAAAAUUCUGAAAUUUAAGGAAAAAAUAUCAUUUGUUGGGAAUUUGUUGGGAUUCAUUGUCUCAGUGCCAAGAGACACCCACUCUUUUUUUUUUUUUGAGACAGAGUCCUGCUCUGUUGCCCAGGCUGAAGGGCAGUGGCACGAUCUCAGCUCACCACAACCUCUGCCUCCCGGGUUCAAGUGAUUCUCCUCCCUAAGCCUCCCAAGUGGCUGGGACUACAGGCAUGCAUCACCAUGCCCGGCUAAUUUUUGUAUUUUUAGUAGAGACGGGGUUUCACUAUGUUGGCCGGCUGAUCUCAAACUCUUGACCCCGUGAUCCGCCCGCAUCAGCCUCCCAAAGUGCCGGGAUUACAGGCAUGAGCCACUGCGCCCGGCCGAGACACUCACUCUUAACAUUUUGGUAUAUUUUUUCUCUCUGCACAUUUUUUAUCCAGCUGACUUUAUUUUGUCUCCUGAAAUCUUCAUUUUUAAAUUAUAGCUUCAGCAUUUAAGAAAAUGUGUCUAACAAAGUCUUCGCAAGCAUACAUUUUUCCCAUAGUUAGUAUACUUAGAAUUUAUUUGUCAAGCAAUUUUGAAGGGCUUUCACUAUGAAAAACUUUAGGGCUUAUUGAUAUUCUCUUUAAGUAGAAGUAUGUUUUUUAUUAUUACAAAAGUUAUAUAUGUAUA

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Publications