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Homo sapiens (human) Alu-mediated CDKN1A/p21 transcriptional regulator (APTR) URS000075BCAA_9606

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APTR: The long non-coding RNA (lncRNA) APTR has been found to play a significant role in gastric cancer (GC) prognosis and outcome [4]. Silencing APTR has been shown to promote gastric cancer proliferation and invasiveness [PMC9463576]. The recruitment of APTR to the p21 promoter does not require the Polycomb Repressive Complex 2 (PRC2) [PMC3991591]. High expression of APTR has been observed in animal models and human patients with fibrosis [PMC8773432]. Knockdown of APTR resulted in cell growth inhibition, which was dependent on p21 induction [PMC3991591]. APTR is one of the long non-coding RNAs (lncRNAs) identified in gastric cancer, along with PVT1, HOTAIR, and H19 [PMC6433939]. A risk-score formula was constructed using coefficients obtained from multivariable Cox regression analysis, which included APTR as one of the variables [PMC6188476]. Similar mechanisms involving lncRNA APTR and XIST have been observed in preventing the transcriptional activation of apoptotic gene expression by nuclear transcription factor Y subunit A (NF-YA) and PANDA combination [PMC8463317]. Positive correlations have been found between APTR and ELOA-AS1, ZSCAN16-AS1, ELOA-SA1, SEPSECS-AS1, DLGAP1-AS1 (|correlation coefficient| >0.3 and P<0.05) [PMC9989802].

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Gene Ontology annotations

Sequence

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GGAGAGUCCUCAAGAUGGAUUUUCACAAAUCCUGCAGCGCACUAACUGGGAGGAAGAAACGAUACAGAAAAUAAGAGUGUCGGCCAUCCCCCUCUCUGCAACCGAAAUUACAGGCUCCAUUUCCUGUCCCCUUGGGAACUGCAAAAUCCUCUGCUGAAAACCGGACGCCUCCCAGCCCCUCCAGGCCGGCGCACGCGGCCGCCGCGCUCCCCCUUCCCGGGCCCCGUGGGCGCCAGGGGGCGGCGGGGACCCACGGCGCCCUCCCCUCCCCCUCCCCGCACGGCACCCACCUCGGGGCAGCGGCUUCACCUCCCCGUUCUCCUCCCGGGAGGCCCCGCCGGCCUCUCGGGCCCCACCGAGACCGUGCCUCCUCCUCUCCUUCUCCCGCUUCUCCUUAGGUCUGCGCGACUUGGCGUUAGCCGAGGCAGCGGCGGCGGCGGCGGGCAGGAGGAGAUGGUGAGGCUGAGCGUGCAGCAGCGUAGGAGGGACCAGCAGUUUGCGCGGCACCGGCUGAGACAAGGAAGCGGAGGCUGAGGAGGGAACGGCCGUGCCAGCGGAGAAAGAGAAACUGCUCCGAGAAGAGGACGGGGAGGGAGCAGCAGACAGAGGGGCAAAGCUCCAAGACGCGGGGCUGCCAUAGCUCUGAGGCGAAGGUGCUGCCGGCGGCUGCAGCUGCCUGCUGUUCCCGCCGCUGCCCCCUUCUCCGUUCACUCUCCGCGGUGCCUUCUUCUCCUCAGUCCGGACCUUCUUGGCGGACAGAGAACCCGGAGGGUCCCGGGAGGAGAGUUGCAGCUUGCCAAACGGUUCUUUCUCCGAGACGGUGGCGGUGGGGGCCGCGGCAGCGACACAGUGCACGGGGCUCGGCGGUUCCGCCAUUUUGCGCUCCUGUUGUAUUUACUCUCCUCCGCUAGCCGGCGCGGGGCAGGGGGCGGGCCCUCCGCGAGGGGUAGGGAAGGGGCGGAGCGGCCAGGCCACCAGCCGGCAUUGCUCCAUUGGGCAAGCCACGCUGAGGGAUCCACCUAAGAGCCAAUCAAAGGCACAAACAUCAGACGAAGGGGCGGGAUCGCCACAGGGACCCUCUUCGGAGGUCAGAGCUCGGCGGGGUGCGGCUAGUGGCGGAGCGCGCUGCGAGGGGAGGGCUUUCCACUGUCGCUGGCGUGAACUCGCGUGCCCGGUGGGUAUCAGGGAAGAACCCCCGCCCCGGACCCCCAGAUCUGCCAUGGCCGAGGUAGCGAUCGUCUCUGCGGCCACGAAGACUGUUUUAACUUGUACCACUUUCCCUUCCAUUUUUCCUGGGGUGCCUCUCACCCUGCAUCUGCGCGUUCAGCAAGCUGGAUUUCGGGAAUGCUCAGUUCAGAAGAGAAAAAAUUGCCGGGAAUCAAGUCCUUCUUUUUGUUAGUCGGUAGUCGAUUGAUGGGAAGUGUUCAAAAUCAUUCGAUGUGGUGACAAGGCUUCACCAGGUACUGCCUUCUAACGAGCUGGCCAUUUCCACAUGUCAGAUAGGACCAACUUGCCUUUUAACUACCCGUGUGAUACUUAAACACUGUUGCCGGUAUCACAGCUUUUCUUCAAAACAGGAAGCAACGAGAAUGAGGGCAUUCCAGUAGCAGGAGACAGCAUGCAUAGAGAUGCUGAUGAAGAAAGAGCCUAGCGCACGUGGGAAACUGCAAAAGUUCAGACUGGUUGGAAUGCUGGAAAUGUUGUGAAUGACAGGAGAUGAGGCUGGCGAGAAAACAGAGGUCAGAUUGUGGAAGGCUGUCAAGCCAAAGACUUUGAUUUUAUUCUUGAGAUUGAUGAGAUGUGUGUAAUCCAGGAGUGUGCAAAACAAUCUGUAAGGGUUCAGAAAACAUACUGCUUCUAUAUAUAGUUACCUUUGUCUUAACUUGAAAAUUUCAAAUUGUGUAGGAGUUACAAUGUGUGUAAUUGUUAUUAUAGUACUGGAUCCAAAUAAUUUAUAAAUAAAUAAAUAUAGACAUAA

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