Homo sapiens (human) long intergenic non-protein coding RNA 1094 (LINC01094)

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Homo sapiens (human) long intergenic non-protein coding RNA 1094 (LINC01094) URS000075BC36_9606

4,300 nucleotides
4 databases (GeneCards, HGNC, MalaCards, RefSeq)
Found in 0 other species
108 publications
lncRNA

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LINC01094: LINC01094 is a long intergenic non-protein coding RNA that has been implicated in various cancers, including glioma, clear cell renal cell carcinoma, and breast cancer. In glioma cells, overexpression of LINC01094 has been shown to promote cell proliferation and motility [PMC8438678]. LINC01094 has also been found to downregulate the level of checkpoint kinase 2 (CHEK2) protein, a key factor involved in DNA damage repair [PMC7315499]. Additionally, LINC01094 functions as a sponge for miR-126-5p and miR-224-5p, promoting the growth and metastasis abilities of glioblastoma cells [PMC8940523] [PMC9504471]. In clear cell renal cell carcinoma, LINC01094 facilitates cell growth, metastasis, and radio resistance through the ceRNA mechanism [PMC9396193]. Furthermore, LINC01094 has been implicated in regulating GBM progression by quenching miR-224-5p as well as other miRNAs such as miR-21 and miR-23a [PMC9068894]. In breast cancer, LINC01094 promotes progression by sponging microRNA-340-5p and regulating E2F transcription factor 3 [PMC9161846]. Bioinformatics analysis suggests that LINC01094 may interact with several other potential miRNAs such as miR-577 and miR-545-3p [PMC7315499]. Overall, these findings highlight the important role of LINC01094 in various cancers and its potential as a therapeutic target.

Genome locations

Gene Ontology annotations

Sequence

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CUUUUCAGUUCUGUCUUCCUGAGGCUGCUGUUUCUGGGCAUGGCCAGGGGAUCUUCAGACUUUACAAACCAGUUGUGCAGAGCCAGGCAUUUCAAUAAGGAACAAAAUGCUGAGUAACAACAUGAAGUCAGAGUGUUGCUUGCCAAGAGCUGGGAGGCCUGGGUGGUUUCCCAAUCUUAAAGAAGCAGAAGGAUAUUAAAGUGAGCCUCCCAAAGGAAAACGUGGAUCUACUUACCAACGCAGAAAAUGAUACACACGGAUUCGAUUUAGGCACGCUACAUUCAAAUGACUUGGAAGAGCAGGUUCUCUGAGCCAGGAUACUAAAGUCCCUGUUUAGGAAAGAGCCACGUUGUAUGUUUACCCUACCACAAAGAUACAGUCAUGUGCCUGGGAAAGAUUGAUGCCAGCUCCAGAAAGGCAUCCGAAUGGUCUAAGUAAUGCCAUCCAUCUGUCAGUAAUAGAUUCAGAAAUGGUGCUGGCAGAGGAAACAGCAGCAAUGAUGCUCUGCGAGCCUGACUCAGGGCCAGCAGUGAUGGCAGCCCAAGAAUUCUGGAGGAAAGUGGCUCUGGGAAUUGAACAGUGGCUCAGUGAUGUUGGGGCCACCAAGUCUGCAAUUCUCCCUACCUGUUCUUCAUGGUUGUAAGAUGACUGCUGCAAUUCUCGGCAUCAUGUGCAUGUUAAUGUCAGGAGGAAGAAAGGAAGAGGGAGCACUGGGAUGUUACAUUCAUUUUGUCAGGAAAAGCAAAGCCUUUCCAGACAGCUCCGAAACUUGCUUACCUCUCAUUGGCCAGCACCAUCACUUGACCACUUGUCCACUCCUAGCUGCAAGGAAAGUGGCAAAGUAGAAGGUAUUUGAGAAUGUCUGCUGGGUUAGCCAAAACAAUAGUGACUUCUACACCCAAUUUUCUGGGCACUGCAGAAGUAUCCUUGAGUCCUAUGUGAUCAGAGGGAGAGCAAACCUCAAUAAUGAAACAGAUUCAAUUUCCAUCACCCAGUGAGACACCAUGGGAUUAGAAUAAAUUUUUAAAAAAACAAAUUGAAAAAAAUGCAUUUUUAAAACAACAAAAUCAGAAAGGAUGAAAGGUGAUAUUUCUAGCAUAUCAGUUUGUGGUGGUAAAUUAAUUACCUUAUACAAAGGCCUCAGUGACUUUCUUCUCCUUACCUAACGAAUCAUCUUUAAAAUAAGUAAAAUAAAGAAACAAGAGCAGCAGCAGAUGCUUCCUAAAAAGAAGUUACCAAAUCUGUUCACCACAAACCUGAGAAUUCAACUGUGGACAUUUGGACACCAGCAAUGAACAUGAAACUCAGCUUAUGAGGCAUAUUUGGCUAAAGGUCAAGGUGACUUAAAGUUCAUCAUAGGACAUCUACAAUUUGCAAAGCAGGUGACUGGAUAUGGACUCCUUCCAAGUCUCAUUUAAUUGGAUAAUGCCUACGUUUUAAGUAUCAGAAGUGAGUCUUUCUCUAUUAAAUGAAGUCAGUUCCACUAAAACCUAAAUCUUGUUUGGCAGGCACUCCAUGUUUCUUAAUUUUUAUUCCAUGCUGUAUAUUCUUUUAGACUUGAUUUUCACUUUUUUUUCUUUUUUCCUGUACAUUUAUCUUUGCUGUGAAACAAAGUGCCCUGCUUUGAAGGACAGGUUUGUGGGCUGCUGGUGGUGAGACAACAGCAGUCCUUCCAAGUCUUCCUCCCAUCACUCUGUUAGCUCUCCCUUUGUUUUUAAUUAGCAUUACACCAGUUAAUUCUGUUAUCUCUUAACCCUGGUUCUGCAUCCUCUUCUUCUUUUCUAUUCCUUACUCCGCUCCUGUUUUUUCUUGUUCUGCUUUUCCAAGAAAUGUCUUGUCUCCUCAUCAGUUGACUGUCUUCUCUUUCCAGAGGGACCAUAAAGGUGCCAGCCUAAGGAACACGUAAAACGUGGGAACAGACAAACAAGCUGCUGCCUAUUACAGAGAUAGAUAAUUAACUUUGGACCAUUACAUGCAAUUCAUCAGCUUAUCUUUUUCAAACUUUAUAUAAGAAGUCAUUUCCCAAUGGUAACCACUUGCCAGCUGCAACUUUGACGCAUAUUAUCAGGAUAGGUGAGAUUGAUGGGGGCCCUUUGAACUCUUCCCAGGGAAUUAUCUUUAUAAUGUUACAGUUUUCUCUAUAGCAUGGUCAUAUUGUUAACAUUGGUUAUAAGGUCAUAUGGUUAGUAUGGUUAGUAUUGGUGGCUCACAGCUGUAAUACCAGCACUUUGGGAGGCCAAGGUGGGAGGAUCACUUGAGCCCUGGUGUUCAAAACCAGCUCUGGAAACAUAGCAAGACCUUGUCUCUACAAAAAAAAAUUAAAUAAAUUAAAAGAUUAGCUGGGCAUGGUGGCACAUGCCUGUAGUCCUCACUACUUGGGAAACUAAGGUGGGAGGAUCCUUUGAGCUUGGGAGGUUGAGGCUGCAGUGAGCUGUGGUUGUGCCAUGGCACUCCAGCCUGGGUGACAGAGUGAGAGCCUGUCUCAAAAAAAAAAAAAAAAAAAAAAAAAAGUACCUGUAAGGUCUUUGGGAUUUUGAAGAUGAAAGGUGUUGCAUAAAUUGAAUGAAUUCACUUAGAGAGAUAGAAGGCAACUACAGGGAAUAUUACGUACAUCAUGGAGCGGAAAGCACUAAGGCCUGUGGAAUUAUUCUCAGUGACACGUCGUUGAGGGCAGUGGUCCACAUGUUUUGAACAUGGUUUCUCCCAGGUGAAAAGGAUGAGUAAUUUGUUCUCCUUCACAUGUGUGUAUGUAGGUCUUAUACACAGCAGAUUUGCCACAAAACAAAUGAAGAUUACACUUUGGGCCCCUCUCUCACAUGAGCCCCUUCCAAAGUUCUGUUUGCUAAUUUUACAUUUUGUAAUUUCUUAUUAUUUUUCUUAAAGAAGCCUCCUCCAAUUGCAUAAACUUCAAGCCUCACAAAAUUUGGAUCCAUACCUGAGCCAACAUACAAUACAAUUUUCCAUUUCUAACUUUUAGUUGUACCUAGUGUUUUAUUGGAAAUGAUCAAGUACAUGAGUGGUGUCUUUUUAAAAAAUUUACUUUAUUUGCUUCUCUAGCUUCAUCGUUAGUUAGGCAGUUAAAUCUAACCAUUUGGAGGUAUUUUCAUAUAACCUCCAUUGAGGACAAUUUGGCAAUAGCUUUUAAAAUUAUAAAUAUAUUUGUACAGUUAUAAGCUGCCAUAUCUAUAAAACUAUUUGAUAGACAAAAGUUGAAAACCCUCCAAGAGCUCAUCAAUAAAAGAUUAAAUUAAUUAUGAUACAUCCAUAUGAGCACUGAGCAGCUGUGAAAAAAAUGAGGAAGUAAUUCCUGUGCUGAUAUGGGAAGACUUCCAAGACAUGUUGUUAAGUACAGAAUGGUGUAUACAGUAUGCUAUAUAGUGUGGUAAAAGGUUUAGGGAUAAGCAUUUAUAUUUAUAACUGUUUAUAUUUACAUAAAGUAAUUCUGAAAGGAUACAAAAAAGCUAACAAAAGAGAUUACCUGUGGUAGUGUGGGGCUUGGGGAUUGGAUGGGUGAGAAACAGUAGUGGAAAUGAGAUAUUGUACAGUUUAAGGCAUUAUACACCUAUAAAAACAUGGGAAUGUAUUACCUACUCAAAAAGUGAAAUUAAGAGAGAUACAAGAAACUGUUUGGAUGUUCCUUCCCGUUUCAAUGUAUCUAUAUUUUUUCAGCCCUCAAAGUUAUUAUAAAUGUCAUUAUAAUAACUUCAUAAAGCUUCCCCUAUAAUGAGAAUCUUACCAUUCUCCUAACUCCAAUAGCACUGUAAUCCACCUCUGUUAGGACACAUCACUCUUCAUCAUGUGUGAUUAUUAUUUGCAGAUAUCAUCUUCAAGGCUCUUCUCUAUUUACCACCUGCCAUUCUUGUUCUCACCUCUACAUGACCUUCACAUUUUAUUUCUCUCGGUUUUUUGGACAAGCUACAUUCCCUUCCACAGAGAAGGCUUCCCUGACCCCUUUCACUUGGUUGGAUUACCUUGCUAUUCUUUUCUAUCUUUGUACAUUCCUUUUCAAAAUACUUAUCUCCCUUGUUGUUACCUAUAAUGUCUGUCUUCUUUACUCAAGAGUCUAGACAAAAAGCUCCACGCCAGCCUCGGCUGUGUUUGUAUUGUUUACGUCUGUGUUCCUAGUGCUUAAUAAAAUACCUAGCAAGGGUUAAUAAGUACUUGUUGACUGGAAGGGAAUGACUUCCUUCCCUUACUAGAGAGUGAUUUCCUUACAGGCGAGAUGUGUCAACCUUCUAUAGCCCACAUAAAAUAAAGGACAAUAUCUCCUAUUGGAUAAAAGACAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications