v24

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Homo sapiens (human) tumor suppressor candidate 8 (TUSC8) URS000075BBEF_9606

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TUSC8: The luciferase activities in MCF-7 cells transfected with the wild-type TUSC8 construct were significantly reduced by miR-190b-5p, while no effect was observed on the mutant TUSC8 construct [PMC7041739]. The binding relationship between TUSC8 and VEGFA was confirmed, and a negative correlation was found in esophageal cancer tissues [PMC8489135]. TUSC8 has been identified as a tumor suppressor in cervical cancer development through the regulation of the miR-641/PTEN pathway [PMC7447318]. Functional assays were conducted to investigate the role of endogenous TUSC8 in osteosarcoma development [PMC7447318]. However, the biological functions and molecular mechanisms of TUSC8 in breast cancer are still not well understood [PMC7041739].

Genome locations

Gene Ontology annotations

Sequence

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GUUCUCUAGUCAGUGCUGCUGCUGGAAACCAGAGUCUUCUUUUGUUUUCCCUCUCACCUCUGGCUGCCUCUCUCUCCCCUCAAAGGUCAGAGCAGUGCCAAGGACAGAAGAGAGAGUAGAUCCAGCCUUGGCCCUGCUAGGCUGGGCAGCCUGGCAGGUAGAGUCAGCAGGGAUAGAGCUUGCUUUCCUGUUCACGAUCUUCAGCCAAGUUCAGGGAGGUCUGAAUACUGAGGCCUUCAUAGCCACUGCACCCCAGGUAGCUCAGGAGAACCUCCGAGCGCAGGAGUGCAAAGGCUGGCAUUCUUCAGGCUCUGAGGCUGUCCCUUCCGGUGGAGGUGAACUGCUUCUUAUUGAUGUGGACAAGACUGUGGAUAAAGUUUGCUGACCCCUAGAGAGGAAGUCAUGGCCCAUGGCUGGCAGAUGGAAGCCUCAGGACCUGAAGAUUUCUCAAAGAAAGGGACCUGCUGCUGACAGCAAUUAAUAUAUGUUCACAGCUUGCAGCUGAAGCCUGAUGAUGGCUGUAGGAGAAAGGACAUCACCCAGAUGACAUUUUGCCUCCAAAGCUCUGGGGACCAAUUGUGGAAGAACUGCAGGGAUAUUAUGUUAGAAUGUUCUUGUGUCUGGAUAGGAUGAGAACUGUCUUAUAACAAAGUGCAGCCCCCAUGUCUGAGGGCAUGUUUCCUGUGUUUAGGCACUUCCGAAGCAGGGAGCACCUUCAAGGGGCACUGGCCUUCCCAGAAACAGUGUUUGACCUGUGAUGAUGUCCUGGGGGAGGGGACCUAGGAAAAGACCUUAGCCUUUCCAUAAGGCACGAUUAUUCUCCUCUAUAGAGCCUCAAAAGUCAAGUCAAGUAGCAAGCACACUGUGCUCCAGUCUGUGGCCACAGACACACACAAGGACUGGAGCAAAACCAAACAUAGUGUAUCAUCACCGCUGAACCCCCAGGAGCCCCCAGAUGCUUUUGAACGUGAAAGGAGAAAGAAGCUGUCAGAGAUCAGGUUGAAUGUGGUGGGUUAGGUGUGCGGCAUUGCCUCUGGGUCCCUGCUUUGGUUUAAUUAAACUAAGUCUGGUGGUGAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications