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Homo sapiens (human) long intergenic non-protein coding RNA 1559 (LINC01559) URS000075BA54_9606

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LINC01559: LINC01559, a long non-coding RNA (lncRNA), has been extensively studied in various cancer types [PMC9421927]. In triple-negative breast cancer (TNBC) tissues, LINC01559 expression was significantly higher compared to adjacent normal tissues [PMC9421927]. Depletion of LINC01559 was found to enhance the expression of PTEN and promote PTEN transcription activity [PMC7477231]. Moreover, LINC01559 was shown to recruit IGF2BP2 to stabilize ZEB1 expression, leading to increased proliferation, migration, and epithelial-mesenchymal transition in gastric cancer cells [PMC8921988]. Silencing of LINC01559 resulted in decreased cell proliferation [PMC7477231]. In the context of renal cell carcinoma (RCC), a 9-lncRNA signature, including LINC01559, was constructed for predicting prognosis in patients with high stage and grade RCC [PMC8806408]. Additionally, it was observed that autophagy induced by rapamycin compensated for the proliferation inhibition caused by the silencing of LINC01559 [PMC8614059].

Genome locations

Gene Ontology annotations

Sequence

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CUCACCAAUGUGGGUGGGCCUCAUUCAAUCCAUUGCAGACUUGAAUAGAACUAAAAGGAAGAGGAAGGGCAAAUUUGUUGGCUGCUUGAGCUGGGAUAUUCAUCUUUCUCCUGAUCUUGGACAUCAGAACUCCUGAUUCUCAAGCCUUUGGGUUUGGACUGGAGGCACCAGCUUUCCUGGGCCUCCAGCUUGCAGAUGGCAUAUCAUGGAACUUCUCAGCCUCCAAAUUCAUAACUCUAAUACACCAGUACAAUGGAAAGAUUCCUAAAUUCAAAAGCCAGAAGGCUGGGUUCCUGUUCCCACCCUGCCUUUUACCUUCUGUGUGUUCCUGAUGAAGACACUUCAUGCUCCACUAUUUACUUACCUCUGAAACGAAGGGCUGACCCAGAUCAGUUGUUCUCUGACCUGCUUGGAGGGACUCAGAGGCUGUGGAGCAACAGAUUUGGGAAUGAGGAAUCGUUCCCUGGAAGAGUCAGAGCGCUCGUAGACACAUUCUGCUGGAUUGCACGAGCUCCUCCCCUGGGAAAUCCACUAAGACUAGAGGAAAGAAUUGCUUGGAGGAUUCAGAGGCUGAAGAGUGGACAGACGGCUUUAAUUGAGAAAAAGAAGCAGAAAAUUGAGGAAGAUGUGAGGCAUCAAUGCCAGCAGACGACAUGUGACAGGUGCUAGCCACAUGGAUCACACUAAAUUUCUGUCAUUUAUAUAGAUAAAAAAGAAUUUCCAAAGAGCUCCUCCAUAAUUCAGCAUUAACCAGCUUUAAAUCAUCACCUUUCUUUACCUUUUCAAAGCACUUUUAUCUAGCUAGCUUUCACUUUCAGAGUGGCCAAUUCAGGUGAGGAUUCUCAAUCCUGUUCUGCAGCUGAGGAACUCAUGCUCAAAAGGGCUAAGAGUUUAUUCUCUUACAUCCAAACACCUUGCUUUUCCAAAUCUUGUGCUCACUUUACCUACACAUUUUGAUUUUUCCAGGCUGAUGACAAGUUAGACAUGCAGACUCCUCAGGCUCAUUCAUAAUCUGUAUAGACAUUACAGGUCAUGCAAAUUUAAGAAAAGGCUAAAAGGUGCCCGUUUGCACCCAACAUGUUGGAUAAUGCCCCGGUAAAGUGGAAAAUCAGUUUCCACAGCCUCGCUCUGUAGGUUUCCUUGGAAUUGUAAAAGCAUAGGACUCUGCCUCAUAUUUAUUUCUAUACGGCAAUGAGGAUAUAAAGGAGCAGACCGAAAAGAGAAAGGAAUUUUAAAAGCCAUGGAAAGCUGCCCUAAAUGUGGUUGGAUAUAGAGAGGAGAGUGCUGAAGGCAAACAGCUGUGCCCUCUUUGCCUUUUUGCUGAGGAAGGGGAUUUAAGCCAAAAGAACACACGUAAACGUGGAUUUCUUAAAGUUCUCACUGUAAUUAUGUAGCCUUGGGAGAUGAGGAAUUGUAAAGUAGAUGCUGGCUUAAACAAAUGAUAAAUCCUUGAGGUGAUGGGCACCCCAUUUUCCCUGAUGUGAUUAUUACACAUAGCAUUCCUGUAUCAAAAUAUCCCAUGUAACCCAUAAAUAUAUAUACCUACCAGUAUAUUUCUGUGGCUAAUCUGAAAGCCACCUGCACCCUUGUGAAGACACCCACAGAGACUUCUGCCUCCCCUCCUACCCUCUGGCCUCAAGAGCUCCCUGGGCUCUCCUGUUGCAGGAGGGAGAGGGAGAGCUUCUUUAGGUUCCUGGUAAGGAUCUCUGAAGACAAUUCCUUAGGCUUGGAUAAUUCCCAGACAUUUGCUAAAAAGCAGCAUCCUCCAAAGCUUUAAUUUGGAUCACAGGAAAAUGAUGCUCCCGCCUCAGAUUCAAACACAGUUUUAUCUCACACUGCAAGCUCCCUGGCAUGGGCAAAGUCCUCGAUGCCUUUCCUGGUGGUUUCCAACAUCAAGGACAUACUUGUUCCUCCUCCUAGCUCUCUCCCUCAGCCAAGUCCUUCCUUACAAUGAAUUGUCCUGCAGAACUCCCUCUUAAGCUUGGCUUCUGGGACAGAAAACCUACUUUCUGAAAGGGUAUGGGGACUGUCAGAGCAUGAACUGGACUCAAGCUCCCAAUUACAGAGCAGACACAAGGCUCUGCCUGCACCAGGCCAUCCCUGGAUUUCUGCAGCUCCAGGACUCUCUUCCAGCAUCUAGAUGCAGCUACUCUCAUUCCAGCUUUGUGUCCUGUUUGAUGCAAAAUCUUUAUUCCUUCCUGUUUCAAUCCCUGUUGCAUAUUCUGUGUGACAAAGCAAGAAGCUGGAAAUCGAGUUCUGAGCUUUAUACCCAGCUCUGCCACAAAUGUGCCAUGACCUUGAAUAAGUCACAUGACUUAUCUGGACCUGGAUUCUCUCAUCUGUAAAAGAGGAAGCUGAGCUAUACUACUUUUAAAAUGUCUCCAGCUUUAAUUUUAUUAGAAUAUCAGCUGCUUCCUCCUCUGGUUUCUCAUGGCAGGUUGUGCAUUCUUCUCUGGAGACACCAAAUUUCAUUGGAGUAUCUCUCCUUACAAAUGUAUUUCCCCACUAGAUUGGCCCCUCAAGAACAAGGAUUGUAUUUUAGUUACCUCUGUUAUCUCUGUACCUGGGGAGGAGUGAGAAAAGGAGAGCAGGAAAGGCAAUGGUAUAGUACCAACAUUUGUUGAGCUUCUAUUAUGAGGAAUUGUCUAUGCUACACAUUGUACAUAAAGUAUGUAUGAUUCACAGUAUAAACAUUAUAAUCUGGAAUCAACCUAAAUGUUCAUUAGCAGAUGAAUGGAUAAAGAAAAUGUGGUAUAUAGACGCAACACAAUACUAUACAGCCAUAAAAAAAAAAAAGAAUGAAAUCUUGUCAUUCAUGGCAGCAUGGAUGAGCCUGGAGGACAUUACGUUAAGUGAAAAAAGUCAGGAACGGAAACACAAAUGCCACAUGUCCUCUUUCAUAUAUGGGAAAAUUUAAAAAGUUACUCUCAUAGAAGUAGAGAGUAAAAUAGAGGCUACUAGAGGCUGGGAAGGGUAGAGGGGCAAGGGUCAUAGGGAAAAGAGAGUUAACGGAUACAAAUUACAGCUAGAAAGAUGGGAAGAGUGAAUUCCAGUGUUCUAAAGCAGGGUAGGUGACUACAGUUAAUGAUUAUUUAUUGUCUACUUAUUGUAUAUUAUUGUAUAUUUUCAAAUAUUGUAUAUUUUCAAAGAGGAUUCUGAAUGUUCCCAACACAACAAAAUAAUAAAUAUUUGAGGUGAUGGA

Taxonomic tree

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Publications