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Homo sapiens (human) TMPO antisense RNA 1 (TMPO-AS1) URS000075B992_9606

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TMPO-AS1: TMPO-AS1 is a long non-coding RNA (lncRNA) that has been found to have carcinogenic effects in pancreatic carcinoma [PMC7882873]. In a study focused on identifying the mechanism of action of TMPO-AS1 in cholangiocarcinoma (CHOL), researchers transfected sh-TMPO-AS1 and pcDNA3.1-HMGA1 overexpression vectors into CHOL cells [PMC8973948]. The study aimed to investigate the role of TMPO-AS1 in CHOL and understand its potential impact on the development and progression of the disease. The findings suggest that TMPO-AS1 may play a significant role in CHOL pathogenesis, potentially through its interaction with HMGA1 [PMC8973948]. HMGA1 is a high-mobility group protein that has been implicated in various cancers, including pancreatic carcinoma [PMC7882873]. By overexpressing HMGA1 along with sh-TMPO-AS1, researchers aimed to investigate any potential interaction or influence between these two factors on CHOL cells. The study provides valuable insights into the role of TMPO-AS1 and its potential mechanism of action in CHOL, contributing to our understanding of the molecular basis underlying this disease. Further research is warranted to explore these findings and potentially develop targeted therapeutic strategies for CHOL based on TMPO-AS1 inhibition or manipulation [PMC8973948].

Genome locations

Gene Ontology annotations

Sequence

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GGGAGGGGCUGCAAACGGCGGCGAGCGCGCGCGGCAACCGCCAAACGCCCGCCUUUGUAGCCCCGGCCCCGCGUCCUUACCCUGCCGACGGCUGCUCGGCUCCGGCCCGCGGCGGCGGCCCCAGAGCCGAGGACCGGGGUGGGCUCGCGCUCUUCGUCACUGGAGAAGUCCGGGGGCCCCUUGCUGUUGGUGCCGGCGGGGAGCGGCGGCCGGUUGCGAGCCGUGAGGUGCUGCAGGACCGAGGGGUCUUCCAGGAACUCCGGCAUCUCGGGGAUCUGCGAAGCCCCCUCCCCACAGCCUUUGCCGCCGCCGCUCACGCCGGCGCGCUUGCUCCUGGCCGGGGACCGCGCUGCCGCCUCCGAGCCUCACGGCUCCUGCCCGGGAAGAGCGCUGCGGAGCGGAACAAAAACUCGCGGACACAAAGCCAAGCCAGACCCGGACACAAAAGACCCCAGAGCCGAACUACGAACCAACUGCGGCCAAGCUGGAAGCUCGCACCAACCCCAGCCCACACACUACAGGCAGGAGGCGAGCAGCCUGCUUCGCCCACGCCCCAAGAACGCGCGCCGCCAUUGGCGGGCGACGGGAGGAAGCGCGGCGGUGAUUGGCGAGACGGCUCGCGCGGGUUCCAUUAGCCGCCGCGCUGAGCGAGAGGAGGUAGAAACGCAGUUUAAAAGGCGCUGGGGCGGGAGCCGAGGCUCCCGGCCCGCUUCUGUUUUCGUUUUCUCCACCCUUCCCCUUAGACGCCGAUAAGGGACAGGUCGUACUGCUUUUGUGCGCCGUUUCCUCUCCCUCCCCCAGCUUGAGAAGCAGCUUUCGUCUCUGGGGUCGAUCGCCUACGAACGCGCCGAAUUCCACGCCAGUGUGAGGACCCUUGGCUGGGCCUUUCUUCCUCCCGGGACACUGAAGCUCCAAGAGUAGCCGCAGCCUUGCCUUCCCCAAACGCUAGCCCUGAAGGGGAAGAAAAGAAGCGAGGCUUGUCUGCAGGCACUCAUAUUCCUUGAUUUGAUUUACUUUGGGAGGGGGAGGGCGGGGAGUUACCCCUCUCCUCGCGAACGCUUCUUUUGUUCCAGAAACCCAGGGGAAGCCAGACCUCUACAAUCGGGCACUUAAAUUACCCUUGAAUUUGUGACAAAAGUGUACUAUACCAUUCACUUCUUAGUGUCAUAGUUGGGGCAUGUCUAAAUUGUUUAAUUUGAACAGUGCGUUCAGACGCAAGACAAAUUCGCGCUUGCAUUUUUGUUGAAACCGUCUCUGGCUUUGGAUCCCACCACCCGCAAGAAUCCUAAACCUAACGUUUGAUAACAAAACGAAGGAGAACCCUUGGGAACCCCCUCAAUGGUCAAUUUAAAAUAACAGAUGGUGCAUAAUCCUAAAGGAAGACUAGUGACCUAUAAUUAGGCCUAGAACCCUAAUCAAACCCGUAUUACCGAUCCAAAUUAAAACCUGGUAGAAUCUAAUACAUUGACUGCAAUUAAAAUGUUUGCCUGGAAAUUAGUAUCACUGAUGACAAAUAUUUGUAUUUCUGAUGAAUAUGUAUGUUUAAAGAUGCUUUCUUUCUAGAAAGGAAAGGAGACCUUGGAUGUAGGGUGUGUUAAUCAUUUCCCCAGAAUCUGAGCUCCAAACUAUGUUUUAGAAACUGGUUAAAUUUUUUUUAAAUGUUUGCCUGCUUUCUACAUUGCUAGGUUAGAAUACAUUUAAAACAAACGCCUUCACUAAAAAUGUUUCCUAUGAUUUAAGCGACUUACUUUUAUUCAAAUUGCGAUAUUAUUUCUUUUAGUGAUAAUUAUUUUCCUAGAGGUAACUAAUUCCUUUAUAAAAAUCUCAGUAUUCACAUACAUUUAAGCAAUGGUAUUAAGCUCAAUAAUGCAAAUUAAAAAUCAGGUUUUAAUUAGCAAGUUGUUAGGUAGGUUUUUAUGAUCCCUUGUAAAAGUUGCUUGGUUUUUUGUCCUCACAGCUUCCCUGGACACAUAGGCAAAUGUUUUUAUCUUCAGAAGGGGAACUGAGCUGAGAGGCAAAGGACCAUGACUUUGCAAUGACUGGUAACCCAGUACGUAUAAUGCAAGAACUGCAUUCUAGAUACGCCUGAAAUUAAUGUUUCCUGGGCAAAAACAUUUUCAUUAUCUUUUUUUUAAUCCCUGGACAUUAGCUACAGGUGGUUACUUGCAGAUUUACUGCUGUAGAGCUCCAAAAUUGAGAUUACACUUUUCAGAUUCUGCGUACCCUAAGGCUAAGAGGUUGGGCUAUUGAGUUUGGGUGGUCUCUUUGGUCCUGAUUGCUACUUCCAAACCAUUUCUGCUCUUUUCUGCUUCAAAAAUAUUUGAAGUUCAUAUCUUCUGGCUAAAUCACUUUCUACUCUCCUUCCUGCCAUCAUCCACGAGCCUCCUGGUCACUUUCCAGAAAUUAUAGAGCUGCUUGCCGUAGGUUUUCCUCACCAUCCCUCUUGUCUACAUUCUAUCUGAAUUCAGCAUGCUUGUAGGUGACCCAUGCAACACCAACACUUGGCCUCUUAGACCUCUGACCUCUUCAUCUCCAACAAUUUGUUCCUCUCUUGCGUCUUAACCACUUCGGUAUCAGUCAGAUUCUGAACCUUGUCAUCAGUUGAAAUCUCAGUUUCAAGCUUCCCAAUUGUCAAUCACUAGCCUUUUUUUCCCAGCUAAUUUAUGGUACUCUCACUUACCUAAUUAAGACCUCCACGCUAUUAACCCCAACACUUAAAAAAACUCAACUCUUCUGCUUCUGCCAUCAUGUAAUAAUUUUGCAACUCACCUGACUUAAAUUCCCUGAUCAGUCCUUUUCAUCACUCUUUUACAAACAUUUUCAACUCUCUGAUCUCAAUGUCUCCUUUUUUGCUUGAAAGAAUCUCAGCCUUGCUUGGACUAAACCAUGCUCCAGCUGAACUUUCUCAUUGCUUACAUCCAAACAGCAAAAGCUGCUGGAGAAAAGUCAGUCAUAUAACAAGCUAACUGGUUUUAAUUCAUGACCUCAGUCCUCUCAGGAGCACUCAACACUGGCUGGCAAUGCUAUUCCAGUCUCUGGGUUAACCAUUCAUACGUUCACAUCUCCUCAAAUUUCACAUCCUUUUUCCCUACCUCUCAUUUUUAGCUGGUGACCUUGCCUCAACUUCAAAAAAUAAAAACCACCUAUGAGGAAUGCUUCAA

Taxonomic tree

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Publications