Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) DIAPH1 antisense RNA 1 (DIAPH1-AS1) URS000075B908_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

DIAPH1-AS1: DIAPH1-AS1 is a long non-coding RNA (lncRNA) that has been found to play a role in the growth and metastasis of nasopharyngeal carcinoma (NPC) [PMC9264946]. It has been identified as an m6A target of Wilms' tumor 1-like protein (WTAP), which interacts with DIAPH1-AS1 to promote the growth and metastasis of NPC in an m6A-dependent manner [PMC9496264]. WTAP enhances the stability of DIAPH1-AS1 by mediating m6A modification through its synergistic interaction with insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [PMC9496264]. DIAPH1-AS1 acts as a molecular adapter to promote the formation of a complex involving lncRNA MTDH-LASP1 and upregulate the expression of LIM and SH3 protein 1 (LASP1), ultimately facilitating NPC cell growth and metastasis [PMC9496264]. WTAP, regulated by KAT3A-mediated H3K27 acetylation, is required for stabilizing the m6A methylation of DIAPH1-AS1 in NPC, playing an essential role in its growth and metastasis [PMC9776883]. Additionally, WTAP has been shown to promote NPC progression and metastasis by increasing the stability of DIAPH1-AS1 [PMC10092764]. Furthermore, insulin-like growth factor binding protein 1 (IGFBP-1), another important molecule involved in m6A modification, has been found to promote cell proliferation and metastasis in NPC driven by Myc [PMC9451570]. Overall, these findings highlight the significance of DIAPHI-ASI as an m6A target regulated by WTAP in promoting NPC progression and metastasis.

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences
AGUACAUGAUUCCCCAGCUUCAAUAAUGGACUAAUGACCCCCGGAAUCCCACCGCUAUAGCCUGCACUUCCCCAGGAAUUCCUGUUUAAGGCGUCUCUCAAUGAAGACCACAAACAGGAAAUGGAGGAGUGGGGAGUUGCCUGACAUCCUGGAAACUACGUUCUUAAAGAACUGCAGGCAAUGGGCGAGAGUUCUAAUACAUGGAACAGUUACAGGACACUAAGUUCUAGAGCAAUUCAUCUCCAGAACAAAAACUGAAAUGGAAGCAAGAAAAAAAUAAGUUUCUCACAACUCCUUCCGUGUUGUACAAGCCCCAGUCCAGCACAAUACUCUGCCCUAAUCACUCUGCCCUCCAUCCAUCCUCUCCAGCAGAGUCAAUCUCUAAGUGGUUCCGAGCUAGUUCACUGACCACAGAGGACUUCUUCAAAAUGUCCUUCUAAGAUGGCUACUGAGAAGUUUGGAAGAUGGCAAGAAAAGUGCCUCUGAAACAGUGACUCCAAAAUUGACUGCCAAGUCAACAGAAAAUGUUGAAUUGUUUCCUAAUCAAUCUCAUAUGACCUCCAUAAGAACAGGGAUAAUACUUAUAUAAUACCUAUUCAGAUACAGAUACCAAAAUAUUAUUAAGAGAACAGGUGAAGAGUGGCUUAAUUCACACCAUUAACAUGUAAACAUGUUACAUGUUACAAACAUGCUCCUCAUGUAAUCCUUAUACUAAAGUUUGAGAUUUACUGGUAUCAACAGACAUUUAAGGCUAGGAACUGACUGUACCAAGAUGUUAGAAGUUUAAGUAAUACUGACCCCCCAACUAGAUGGUCUAAGUCUCAGACAAUGACAUUUAAAAGGACAUUUGGUUAGAAAUAAAAUCUGGAAUCCACAGAUAAUGGCAGAUGGUACCUUGGACUUAAAAGAUACCAUUUCAGUCUAUAUGUUUCUAGAAAAGAGUAAUACAGGCACACACUAAAGCUGGGAUGGCUAGAAAGAGGCUCUAAAAAUGAGACUAGCUGGGGAUAAUUAGGAGUUAACAUAUGACACAAAGGGUUGACUUUGACCGUGAAAAUCUUUCUGCACCAGCAUAUUCUAUCCAAGUUAGACCAGGGGAAUUCCCUGAAGAAAUGGAUUCAGUAUGUUAUCUCAAGCUAGUUAUCCAUAUAUAAUGUGGGUAGGUUCUAUUAUGCGCUUAAAGUAGUUUUUCAGCAGAAACUGAGACAGAGAUGGGAUUAUGAGUGUGUAUAUAAUGAGGCUACAAUGAGCUACCAAGCUGAUAAAAUACAAACCUCUCUUUGAGCCCUCUCAAAGGAAGGCUAUGCUUUCAUGAAGGUAUCAGACUAAAGAACAAAAACCUUUCCAGCCUCUGGACCCCAAAAAGAACACGAAUAUUGCUACUAUUGAAAAUACUAGCUGCAACAGGACAAGAUCCUUUUGUAAAAGGGCAAGCUGUAGCUUUCUGCAUAAUUUAACUGCUGAUCAGUCCUCCAAAUAAAUUUCCUGACAGGUAGAGGGCAGUAUACUAAUCAGCUUGUAUUUGGAAAGGACAGAGGUUGCCUCUCUCUAACGUGAUGACAUCACUACCAAACGCAACAAUGACACAUCUAAAAUAAAAGGGAUCCAUGUGCCAUCUGGUGGCUGAAAGCAGUAAAGCACACUGCUAGAAAUAAAAUAUCAAAUUCCCACGGUUGAGAAGAAAAUUAAAACUUAAUUCCUUUACCUGAUGAUGCAGUCCCUUAAAUCUCCAAUAGUAAGUCUUCUGUGGAAACUACAUCAGCAGCCUUCGCGCAAUAGUUUUAAAGUUUUGCCCCAGUUUAGCUCUAUACUCCUAAACACUGGCUGUAAGCAAGCAGCAGCUCCUGAUGCCUGACCUUUGGUGCAUAGAGUAAGAGAAUGAAACUCAGACCAAAACAAACAAAAUAACAAAAGGACCUGGAAGGCUGUCAGAAACAAAAGAAGAGUUUGACAUGACAGAUAACACCAAAGACAGCUUAUUGCAAGGAAAAAAAGUAACAGAACCAGAAGUUUAAAACUGAAAGAUACCUUUUAGGUUCAUGUAUCUCACUUUACAGAUAGAGUCAAGGUAAGAAAGAUAACCCCUGGUGCAAUCUUAUUAGUGGUCAGACUAAAACAACAUAUCACUUUUCCCCUACUAGACAUUACCAUAAAUAUUUUUUUAUUUUUCGUGGAAGUAUAAAUUGCUACAAUCUUAUACCUAGCAACUUGGGCCCACAGAUUUUAUUUUUAAGAAUUUACUGUGCAGAAAUACAAGUUUGCAAAGACAAUUAAAAAUGGAUGUUUCCUUCAGCAUUGCUUGUAAUAAAAAAAUGGAAAACUUAUUUGUAUUAUAUGACAGAAUACAACUAUCAGAAAUAAUGACACAAAUCUAUAUGUAAGGACAUCGAGAUGCUAAAACACGUUAAGCAAAAUACAAAACAGUAUAUACUGUAUAAGAUCACACCAAUUAUAUUAAAAAAGAAGUGUGUAUACCU

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications