CACNA1C-IT3: CACNA1C-IT3 is a long non-coding RNA (lncRNA) that has been found to be specific to testis tissue, suggesting its potential role in the male reproductive system [PMC8231607]. It is one of the nine lncRNAs (GRM7-AS3, ARHGAP26-AS1, BSN-AS1, KRBOX1-AS1, CACNA1C-IT3, AC012361.1, FGF14-IT1, AC012494.1, and GS1-24F4.2) that showed testis-specific expression [PMC8231607]. CACNA1C-IT3 interacts with miR-204-5p [PMC8231607]. The expression of CACNA1C-IT3 and other lncRNAs and miRNAs could potentially be used for diagnostic applications in male infertility after SARS-CoV2 infection [PMC8231607]. In addition to its role in male reproductive system disorders, CACNA1C-IT3 has also been implicated in other diseases. It was found to be downregulated in FHL1 knockdown cells and associated with calcium channel-related transcripts [PMC6534093]. Furthermore, CACNA1C-IT3 was identified as one of the 15 exosome-related lncRNAs that could serve as a prognostic signature for assessing the overall survival of breast cancer patients [PMC9789946]. In the context of acute lymphoblastic leukemia (ALL), CACNA1C-IT3 was among the significantly upregulated lncRNAs in bone marrow samples from patients with ALL [PMC8290159]. The differential expression of CACNAIC-T3 and other lncRNAs could potentially serve as diagnostic and therapeutic targets for ALL [PMC8290159].