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MIR346: MIR346 is a microRNA that has been found to play a role in glioma cells. It has been shown that MIR17HG acts as a competing endogenous RNA (ceRNA) by binding to MIR346 and miR-425-5p, which helps to counteract the negative regulatory effect of these microRNAs on the TAL1 gene, thereby influencing the malignant behavior of glioma cells [PMC6348679]. In addition to MIR346, three other genes (C10Orf57, RGR, and SFTPD) were identified in the E-MTAB-1781 dataset, while 34 other genes were found in the SEQC-498 database [PMC10093755]. Furthermore, in a study involving 48 metastatic castration-resistant prostate cancers (mCRPCs), it was observed that 4% of cases had a deep deletion involving both MIR346 and PTEN genes, compared to 22% of cases with deep deletion of PTEN alone [PMC8939142]. These findings highlight the importance of MIR346 in various biological processes and its potential role as a biomarker or therapeutic target.
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