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Homo sapiens (human) family with sequence similarity 225 member B (FAM225B) URS000075B874_9606

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FAM225B: FAM225B is a long non-coding RNA (lncRNA) that has been found to be upregulated in high-grade serous ovarian carcinomas (HSOCs) [PMC7821338]. Overexpression of FAM225B has been shown to increase scar fibroblast proliferation, but this effect can be significantly inhibited by 3-MA [PMC7821338]. Conversely, restoration of miR-613 has been found to reduce FAM225B expression [PMC8860311]. The expression of FAM225B has also been identified as a significantly independent prognostic marker in recurrent glioblastomas (rGBMs) [PMC7704151]. Furthermore, it has been reported that FAM225B is upregulated in HSOCs, suggesting its potential role in the development and progression of this cancer type [PMC7821338]. To investigate whether FAM225B mediates malignant phenotypes of nasopharyngeal carcinoma (NPC) cells through a CCND2-dependent mechanism, CNE-2 and SUNE-1 cells were co-transfected with pcDNA-CCND2 or pcDNA-NC vector along with si-FAM225B or si-NC. The results showed that the expression of CCND2 was affected by the presence or absence of FAM225B [PMC8860311]. In summary, FAM225B is an upregulated lncRNA in HSOCs and its overexpression promotes scar fibroblast proliferation. Conversely, miR-613 can reduce the expression of FAM225B. Additionally, high expression levels of FAM225B have been associated with poor prognosis in rGBMs. Furthermore, it has been shown that FAM225B may mediate malignant phenotypes in NPC cells through a CCND2-dependent mechanism. These findings highlight the potential role of FAM255B as a prognostic marker and therapeutic target in various cancers.

Genome locations

Gene Ontology annotations

Sequence

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CAGCCAGGAGCAGAGAGCAAGGGACGGAGAAUGUCAGCGAUUCCGGGAGAGCCCGCGAGGGGGCGAGCGACCACCGCUCGGCCGCGAGCUCAGCGCUUCCCUCGCCGCUUCCCAACGGCCAGCAGAGGGCGCGCGCCUGGCGCUGAGCCCAACCGCCGCCUCCAACGGGACUGGACCAGACCGGGUGGGACCGGACCGCGGUUUGAGUCCAAGCCCAGCGGUGUUUGCGGCGGGUCCGGGGCCUGGAAGCGCGGGGGCGGCGCCGAGAACGAAACUGGAAAAUGGCCUUCAUUGGAAAAGCCCCAGUCCUCGGGGAGCAGAUCCCCCAUCUCUGGCAGUGCAGUGUGCCUGGGAGCUGUCUGGAACAUUCCGCAACGGUCACUCCUCUGCCCUGCAUUGGCCUUGACCACAUGACCCAGAGGUGCAGGGAGAAGCCUCCCUUGGAUGCUUGGAGUGACUUCAGCUGCUGAGAGUGUCUAAGGAGAGCCGGGAACACCGCACGCUUCCUGCAGAUGGCGGGGCAGACCUGUGUGCAAGAGUGCCUGAAGGGGAUCUCCCGUGGCGCUACCUGGUCCAGGGAGGUCACAGAGAGCUCCUCCACCCUGAGCACAGGGGGUCCCACCAAGGACAAGGACAAGAUUCAGCACCGUCGCACACAGAACAGCUACCUGGAGCCACAGGUCACUUUCCAAAAAGGGAGUUUCCAGGCCAGAAGCCAUCCCUGCAGCAUUGUCUUUGUGCUCCAAGAGAAGCCCUGGCACACACUUCUGCUCAGAUGGAACCACUGUUCCCUCAGUGUCCUUGUCAGUACCAGCUGGUGACUUUCCUACUCAAACCCUUCCCUCACUCUCUGCCUCAUUUUCUCAAGGUGCCGUGUUUGCCUGAAAGGACAUUGGCAGCCAGCAGGGGCGGCGGCUGGUCCUCUAGAUGGGCACGAAUGCCAUUGGCAGGCAAUGGGGCAGACUCCAUGGAAAGAUGCUUCUCUUCCUCAAGGUAUGCACUCAGCGGGGAGACCUCAUUGUCAAGUUCAGAGUUACGCUGCAGACUGCACAGCACCUCGCCUGCUUCUAGGGCCUGCUCCGGUCAGCCCAGGACCCACCACAGCAGGACCCCCCAUCCUGUGCUCACCCGGGGCUUGUCCAUGGCACUGGAAACUCCUUCCUGUUCCUGAUCCCCCUCUGGGCGAGGGGUGGGCAGGGACAUGUGGCUCGUGCCGAGGUCUAAUACUGUGUUCCCAGCAUGGAAGCAGGUGGGGACACUUCCUGUGGCAUGCAGGAUUCCGUGUAGAAAGCUGUGACUGUCACCCCUCCUCCCCACUCAGUUUUGUUAGUGGACCUUUCCCUGGCCCUUCUCUCCUUGGCCCCCUCUUGGCAGGAGAGAGGAGGAGAGGAUCUCACUUUCCCCCUGUACCAGCCACACCCUCGGUCUGCGGGGUUCCCAGCAGCUGGCCAGGGAUGCUCCACACCUGGAGGUCAAGUAACCGUCCCCUCACUCUGGGCAUCGGUGCCCUCUCUGGGGUUGGAACAGGAAAGAAAGCCAAGACCUGUAUGUGGGACUUGAGUUGAGACUCAAUUCUGUAGAGUCAGGGGUGAGGAGGAGCCAGGCCUCCUGUGUGCUCUCCAUACCCCAGAGCCGGGUGCCCAGUUCCAUGGGUCCUGAUGGACAGAAGGGAAGAACGGGGGGGCUGCUGCACCGUGGGUGGUAAUGCAGUGGGAGCCACCUCCAGCUGAAUGCCCAGGGACUCCUGGGGCUGCUGGCCCCGGGUCCCAGCAGUGGGUCCUGUUUCUUCUUUACUCUUGGAAUGCAGGAUCUGCCACACCAAAACGUCCCCUCCACAUUUGGUGAAAUAGGAAGCUCCAUGGCAUGUCUCCAUCUUUCAAGGUGACUGAGAGGUUUAUUUUCAUAGGAGCCUCAGUGGCCUUGUCCGUACCCACCUCUGCACGUGGUUGCAGAAAGUGAAGGAUUGUCAGGGAGCAGGGCAGACAUUUGGUUUAUCUGUGUCAUUGGUCAAAGUUUUGUUUUUCCUCCAGAAGAAAAAGGCUUGUGAACAUGCCACCGUAUUCUUCAUUCCUUCUUUUGGAAAUGUAUGAAGAACGGGUGGCAUUUUGGAGUUAUUGGCCUGUGAACAGCUGGCCCAGAGGAAGGGUUAGAUGUGGGUGGGUGUGGCCGCCUCUGCCCCUCCCCAGCGCAGGUGUGCGUGGGCAGCCCAGGCAGGCGCUCAGGAAGGGUGAGGUGGAGCCCUGCACGCUCUGAGCACAAAGUCCUGGGAUCCCUUAAACCCAAGCACUGCCUUGACAGCAGCCAGCAUGGCUGAUAGAAGAGACACAGAAGUCCAGCUGAUGCCAGACAGAGGGCGUCACUAGAGAGCCGUGCUAGGUGGGGGUCAUUCAAGUUGUCUUGGCGUAUGCAGACGUUGCUUCUAGAGAGUCAGAAGCUCUAUAUGCGUAGUGUUGGAGCAGAAUUUCGGGAUAGUGAUGGCAAGCCUCCUCCCAAGCCAGCUGGGGAGUAUGGGGAGGGGGUGGCCGGAGGAACCUGGCAUCCCCGGGUUAGGACCACAGAGGUGGCUCUGCCUGCAGCUGGGCCUCUGCCUCAUCCUGACUCCCCCUGCUUUGGCCAUGGCUCUUCUUGUCCUUCCUCUUCUCAGUGCAGGAGGACCCUGAAUCAAAUGCCUCAUCCUGGUUUGCAUUUUACCCUCGGAUGAAGCUUGUGGCGAACCCCUGGACUCUGUGUCUCCUGAGUCUCUGCAGACCUCGGGUCCUGGACCCAGAGACUCUUCUCCCUGGGACAGGAGGCACUGGGGUGGGUGGACAGGGGUGGCCUGGGGCACAGUAGCUGACGGGGGGACUUCCUAGUUUUCUGGGCCUUUCCAACUCUGAGUGUGACCUUCCUAUUCUUGAUCACAGCCCCCAACUUCGGAGCCUGCUAGAGCCUGCAGAAUGUGGCUUCAUCCUCUUCCUCUGUGGGAAAAGGCGGGGCCUGGCAGUCCCGCCAAUCUUGUAUAUUUGCUCCCCACCUCGGUGGUGAAUACAUUCUUGGGUGGUGAAUAGGUUCUCUCCUUGCCUUCACUCUAGAAAAGUCCCCUGUUUUGUGAUGUAGGAUGUGGUCAAUGACUGACUCGUCCCUUUGGACCAUAGACGCAGCUCUGAUUUCUGGUGUUCCUGGGCUCUGCACACAGCAGGAGCCACUCUGGGCUCUGAGAGGUGCAUCUUCUGGCUCACUUUCUUCUUGUUGGCUCUUCUCCCUGCGUCUUCUGCCACUGCCCUGUUCUGGGUGGGAGGCUGUCACACUGUGGUGGAGGGUCCCCUCUCCUGCCUCCCCUCUUUGAUCCUUUUCUGUGAGGGUCUGCUGGGGUCCUGUGUGUCGUGCAUUGUUGAUAGAUUCCUGUCGUGCUUGCUGUCCUCCCCAUUCUAAGGGACCUCUGAUUGCCUGUGAGCAGUUUACAGGGUCCUCUCCUGGCCCCUUCACCCGAGGAAUUCCCGCAACGCAUGAGUUUGUGAGGGGCGGAUCCUGGGAGGAUGUGACGUCAGGUGAGAAGGGAGGGCCCGUCCUAGUCCGGUGGGCUCCUCUAACAAAGUGCAUUAGCCUGGGGAGUUACUGACGCUCGAAAUAUGUCGUCAAAGUUCUGAAGGCUGAGAAGUCCGAGAUCAAGAUGCCUGAGGAUUCAGUGCCUGGUGAGGACCCAUUCCUUAGGGCAGUGCCUCUAGCUGUGUCCUCAUGUGGCCGAAGGGGACAAGGGAGGUUGCUGGAGCCUGUUUGAUGAGAGCACUACCUUCCUUCAGGAGGGGAUUAUUCAGAAAGUCUGUCUGGUUUCAGGGCAUUCCCAAAGGCCCCACCUGUUCAUUCUACCCCAUUGGUAGAAUUCCCAUUGGGAAUUAGGCUUCAACAUACAAAUUUGGGAGACACUGACAUUUAGGCCAUAGCGCGUCAAAGGCAAAGUGAGGCUGAGUGUGGAAACCAUCCCAGAAUCUGGAUGUGGCCCAGGCAGAAGGAAACUCAAAGUGAUGGGGUGACCGAUGGUCCCUGGUCUGUGCAGGACUCAGCGGUGCGGAUGGCCCUGGGCACGGUGGCAGUGGCUGUUGGAGGAUGAUAGGGAACAUGUUGGUGGGGGGAGGGUGGAGCCCACUAUGAGUGGCAACUCCCUGGGGGCACAGGAAACAAAGCUAGAGGUGGCUCCCCUCUCCCCUCCCUGCACACAGUGUCACCUCUGUGGUGGCCCUGUCGUCCGCCUCAGUUCACAGGUGUUGCUGUAACAACUCCUGAAAUUACCUUCAAAAGGAGGCUCGUGCAGGUGCCUGCAGGAGCCAGGAGGCCGAAGUGCAUCCUGAGUGUCCGGGGACAGGCCAGCCUGGCGGGGUCCACGGCCCCACAGUCCCAACGACUGCCUCAGAAAUGGGCAGAGAGCAUGCCUGGUUCUAGCUGGCAAGGCCCACAUCUCAGAGCUGUGGACAGUCAUGAAGGGUCCGUGAGCAUGGAGAGGGGGCAAAAAUGACCCAUGAACCUCAGGCCACUGUGCUGCCAUCCAGCCAAGUGCGGUACCAGCCCUUCGGGCCUCGAGAUCCUCUACCCUUCUCUGGGCCUUGCUGAUUUCCUCCUCCAGCCCCUCUGUUUGUGUACGCACAUACACACAUGCACGCACGCACACGCACACCCAGUGCAAUUUCUCUCUGCUCCCUGUACUCCCCAAAAUUCAAUGGGUUCCUCUUUCCUCCUCAGAGAUAUAGUCCUGGGCCCCAUCUCAGCCUGCAGAGGCCUGAACGUUUCCCAGGAUUGUCUUCUAAUUCUCAGGUCCGGCUUUAAAACAAAACCUAAACUAAAACUAAAAUGCUUUCUGCAAAGAAUAAUACACCAACAUAAAGUCCGGGUAUCCUAAGCAUGUGGUGUGUAUGGUGUCUGAAAUUGAAUAUGCUGUGAAACUGCCUGUGUCGAAAUGCAGUGUUUCCCAAGACCUGGAGGCUCUCUCCAGCUGCUGAUUGUGAUCACCUCUCCCGAUCACCGCUGAGCCCUGCAGGUCACCUUCUCCUGACCUAUUACACCACUGAUUGCUUAUGCUGGGCACAAUUUUAUACCCUUGCUGUUGUUCAGUCUAAUCAUCCCUAUAACCCUAUCGGAUCAUUCCCAUAUGACAGAGGAGAAAACCUGGGGACACAGGGGCUGUGUCCUGGCCAAGGCCUUGCUUGCAGCAAAAGGCAGAGCUGGGGUCUAGCCAGGAGCCCCAGCACAGUCCUGUUCUUCCCCCACUAAACUGAGCUGUGAAAUAGAUCAUGGCAGUUUGGAAAACGGGCUAACUGUAUGCUGAGGGAGGUGGUGACGGAUACCUACUUCUUUUCAUGGGAAGGUGAGGUGUCUCCCUGCCCCCCUCAGGUCUAGCCUCUCUCUGUAGCUCAGAACCUUGGGAAAGUGGGAGGCUCAGAGGAGGAAAGAGAUUUACUUGCCCAAGGGCCGCAGCUGCUAAGUGGCAGGUAAGGGACUGUUAUUCUCCUGUCCCUUUCACAGAGGACAGGAGGAAAGUGAGGACAGGUGGUGUACAUGCAUCUUUUCUGCAGCAGGCCCAGAUCAGCUUUGCACAUGGUGCUGACCUCAAAUUCAGCCCUAGAGGGGCCUGUCUCUGCCCUGAGUGAGUAUUGAAGUGCAGGCUUCUUCCCCUUUGUUCUGUCCAUUUCCAAAAAUGUGAACACACACCUCCAACAUGUUUCUGUGUAUAUUAUUGUGUGCAUAGAUACUACCAUUGUGAAAUAUUAUGCAGAUUAAUAAUGCACUAUGCCAUUGAAAAUUUCAAAAGAAAUGUGUAAUGAACAUUUAAAAUUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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