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Homo sapiens (human) NUP107 divergent transcript (NUP107-DT, STX18-AS1) URS000075B50B_9606

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STX18-AS1: STX18-AS1 is a long noncoding RNA (lncRNA) that has been shown to play a role in mediating promoter interactions in human embryonic stem cells (hESCs) [PMC8636647]. It has been suggested that STX18-AS1 represses a CTCF-mediated insulating interaction with the promoter of the target gene MSX1 [PMC8636647]. Knocking down STX18-AS1 RNA intensifies the MSX1 promoter interaction and down-regulates MSX1 expression [PMC8636647]. SNPs in the STX18-AS1 gene have been associated with atrial septal defects of the heart [PMC8636647]. In gastric cancer tissues, STX18-AS1 is downregulated compared to normal gastric tissues [PMC8357526]. In human atrial appendage samples, STX18-AS1 expression is detected and may be associated with ASD occurrence [PMC9747642] [PMC4395394]. The expression of STX18-AS1 is also associated with lower expression of PRKN, regulated by miR-199b-5p and miR-484 binding to ENST00000670511 (AC090825.1) and ENST00000664283 (STX18-AS1) lncRNAs [PMC9690016]. Overall, STX18-AS1 acts as a positive regulator for MSX1 expression and may have functional implications in heart development and disease.

Genome locations

Gene Ontology annotations

Sequence

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GAAAAAGGUUCCGGCCUCAGCCGGCGCACCUGGCGGAGGAGGAACCUCGCGACGCGCUCUCGGGCAUCGGUUUCUCCCAGCAAAGCUUGGAGGGUUUAGCUGCGCGGAGAGCUCAGCGAGCUCUUCUGUGUCUGUUUGGGGCGUGUGGGCUCCGGGAGCGUGAGGACCGGGAAGCUAGGAGGCUCCUUCCCUUCUGGCGGCUCCCUCACUGAGACCGGGCGGUUUGGUUGCGGGGGAAGUGGAGACGAGCCACCCUUGACCUUUGACUGCAAGAACUCACCUUGAGCAGGAUAGAGGCACGUGGACGGUGACCCUCGGGAUGCAAUAAAUGCUGAGACAGAUCAGCAAACAUUGAGUGGGCCAGACACUGUUCUGAAAAAUACGCAGUCGACUUUUGAACAGCACAGGCUUGAACUGCAUGCGGCCACUAAUACUCGGACUUCCUUCUGCCUCUGCCAUCCCUAAGACAGCAAGACCCACCCCUCCUGCUCCUCAGCCUACUCGAUGUGAUGAUGAUGCAGAGAUUCAGAGAGUCUAAGCAACUUUUCUAAAUCAUCUAGCUGGAAUUCAGUAACUGAGCCAGGAUCUACCCCAGGUCUGUCUGACUCCAAAGCCUGUGUCUUCCAGCACACACUGCUGCUGCCUGGGGAAUGUGGAUAUGAUGUCUGGAGCUCUAGCAACCAUAUCAGACCACAAGGAUGAAUGUACACCCCAGGAAUGGAAGAGAGGAAAGCCAGAAAAAGACUCGGUCCCUGAUGGCUGAAGAGCUACCAUACCUGCCCCUAGAUCUUCUAUUUCUGAUCAUCUUCUAUGCAAGGCCUGGAAUGUAAUCAUGGAUAGCCAUGGAUGAUCAGCUUUCAUCAUGUGGGCAUGGAACAAGAUGGAAGGAAGCUGGGGCCCUGAGUGACCUGUGGAGCAGAGGCCUUUGCCCACCCUGGGCUGCCUGAUUUCCCCUGGACUAUCAUGAGACAGAAGAAAAAGCUUCUAUCUUAUUUGAACCACUGUGUUUUGGGAACCUUGGACUAGAGCAGCCUAGCCUUCAUACACUAACAAGGUACAUUACUGACUUCUCCUGUUAGCUCUGUCGUGCUUACAUCAUGAUGCCCAUUUUUCAGGUAAAGAAAUAGUGGCUCAAACAAGGUGAGUGGCCAAAGAUAACAUAGCUCAUAUGUAGCAAAGCAGGGACUUUGAUCUGGGUCUCAGCACUUUGUCCACCAUGGUGUCCACUGGUUGACUCAGGUGAUUCACCUGGGUAACAAGGCUUCCUGAAGGCCACCUGCUGGUAAAUGUCAUUGCCAGUUCAUUGACCGGGAGCCCCCAUGUGUUUCUACCAAGACCCCGCUCCUCUCUUCGCAUACAGUAAUCUGUUGUAUACACUUUGUACCUCACCCACAAGCGUGUGAAAAGCCUUAGCUGUUCUGGUGCCAGGACUAAUGGGAGCUGCUUACAGUCUAUGAGGACAAUCAGACUUGGCCGCCUGCCUUCUUUCCAUAUAAUUUUUAAUAAGCCAGUAAUAUCUCUCCAAGCACUACAGACCUCUGGCUUGGACCAGGAAACCUGGAACUGUUUAAGAGAACAUUAAUUUCCUUUGAGCUAGGAUUACAGGCCAUCUAAAACUUCUUAAUGAAUGGCCACACUGCCUUUUUGAAGCAUUUGUGUAUUUGCCAACACAGACUCGAAGGUUGCAUUAGAUAUUGGGAGUUGUCUUUUCUGGAAGUUAGGGUCUUCUAGAAGCUGACGGGCGAUGGAGGCCUGAUGCUCUGCCAUUUCUUUGGUGAGACCUCUGGACUGCUUCGUUCAUAGUCCUCUUUCCCACAUAUGCUCCCCUGAUGUCUUACUCUUUUAUUUUAUGGGUUUUUGGUAACUGAAACAUUUUAAGACUCAAUUCCGCCACUUUGUUGAAGAUAAAAUCAAGUUCAAACCCUGCUUUAUUUUAUUUUUCUUUUUUUUGGACGGAACUAGUGAGGAAACUGUGUGUGCAAACCCCAGAAAACCCACUUGAGACCUGAUGCUAAUUGGCUGGAUGAUGUUCAAUAGGACACGGCUCCACUGAGCCUCAAUUUCCUGAUGAGGGUUAAACUGAUGAUUCUUAACCAGGUCUGACAUUCUGUAAAUUAAGCAUACUUGCUUCUGAUUUCACAGUUUCCAUGGGAUCAGAGGAUUGAAAUGUCAAGGAACCUCCCUUGAUGUCCCCCUAAGACUCUGAAUUGAACUGUGAUGAGGACCCUUUUGAGAAUCUUUCAGUGAUCCCCUUCUCUAGGAAGGAAGGGUGAAGUAUGCUUUGUAAGAGAGAUUGUCUAUUUGUCUUUUAUCUCCUGAUUUCAAACACAGUGGUUCCGCUAAGCUGCAUCUUUUUUGUUCUUUCUGCUGUGAAAAUAAUUUUGUCGGAAAAUGUAACCAGUGCAAUUAUACUGAAAUUUCAUAUGAAAUGUUAAUAAAAUGGAUGUGUGACCAAUAAAAUACUUGAUGCCAAAUUAAAAA

Taxonomic tree

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