v24

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Homo sapiens (human) long intergenic non-protein coding RNA 173 (LINC00173) URS000075B380_9606

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LINC00173: LINC00173 is a long non-coding RNA (lncRNA) that has been implicated in various cellular processes and diseases. It has been shown that knockdown of LINC00173 inhibits the proliferation, migration, and invasion of glioma cells [PMC7429190]. Additionally, the inhibition of LINC00173 v1 enhances the sensitivity of LSCC cells to cisplatin and overexpression of FAM201 A improves the radiosensitivity of NSCLC [PMC9016135]. Silencing LINC00173.v1 has also been found to inhibit the proliferation and migration of vascular endothelial cells by influencing the expression of VEGFA [PMC7260858]. While loss of LINC00173 does not directly affect viral replication in cell culture, it does affect cytokine expression in Jurkat T cells [PMC5623643]. Furthermore, there is an inverse correlation between LINC00173 expression and miR-641 expression in HCC tissues [PMC7988719]. LINC00173 also plays a role in chemosensitivity to cisplatin in LUAD by enhancing the binding between PROCA1 and ZFP36L2, leading to degradation of BCL2 mRNA and activation of the mitochondrial apoptotic pathway [PMC9830831]. It has been shown that LINC00173.v1 aggravates angiogenesis and progression in lung squamous cell carcinoma by inhibiting miR-511-5p-induced VEGFA degradation [PMC9221461]. In BCP-ALL cases, LINC00173 is underexpressed compared to healthy subjects [PMC9201104]. The molecular function and clinical relevance of LINC00173 in ALL have not yet been explored. Additionally, there is evidence suggesting an association between LINC00426, LINC00861, and tumor immune regulation [PMC8699570]. In summary, LINC00173 is a versatile lncRNA that plays a role in various cellular processes and diseases, including glioma, LSCC, NSCLC, vascular endothelial cells, cytokine expression, HCC, LUAD, lung squamous cell carcinoma, and BCP-ALL [PMC7429190][PMC9016135][PMC7260858][PMC5623643][PMC7988719][PMC9830831][PMC9221461][PMC9201104][PMC8699570].

Genome locations

Gene Ontology annotations

Sequence

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AGCCUUCUGGGUCCGAGGCUCCCACCUGCUCUAAGCGCUUGACACCCUUUAAAAAAAUGUAUUUAAAGAGGCUGGUUCCUAUCCAUCCGACUGGAGGCAUCUCAGUGCAAGAGCAAAGCUAAGUCCUGCACACGCUCCUCCCCUCCUCCUCCUCCUUCUCCCCCCAGGUUUUCCCGAAUGUAUCUACUCCGGUUACAACUAGACGCGGCCCCUCCCCCACCUGCCUCCCCCCUUCCUUCCCUCGAUCGUGGAGGGAGCGUUCUCUGUGCCUUCCCAAGUCCCCGUGGGGGACCUUCUAUGUUGGAGUGGGGGGAGGGGGGGAGGGUCAUAUAACGAAGGCCAGAAAGAACAAAUUAGAUAAUCAAAAGAAUUAUAGUAAUUGCUUUCACUUUCCCCCGCCCGCUCAGCGGAUUCCCUCCCCCGCCCCUCCCCUGGUUUUUCUGUCUGUCGGGAAUACUCGGUCUUUCCGACCCCCUCCCCUCCCCCAGGUUCCUCCUCUCCUCUCCCCUUGCUCGCGCGUUCCCUCUCUUCCUCCGUUUUCUGGUGUGCUGGAACGUUCAGCGGAAUAUGAUGAAUGAUCACCUGUCACAGCUUGUUUAUUAUAAUGCAGGCAAUCAAUUACACAUCCCCAAUGCUGGCCGGCCCGCAGGAAAUUUAUAUGCUCAGCACAAACCAAUGUGAAAAUGGAAUCUCAUUUGCCAAAUGUCUUUCUCCCCGUACAGCACGAUGAUUACAGUCUGUGUUUGUUUCAACAGUCGUGUACAACUGACAGUGCCAUCAUUUACUGCCUGGCUCAGGUCACGUUACUCUAAGGCUUUAUUUAUGGUGUUACGAAGGGCAGCACAGGAAAAGGACAAGGGUGUCUGUCAGGGAUGGCACUGUGUUAAAAAGUGGGCGUGCAAGGGCCGCAUUCCCGGGCAGCCGCUGCAACCUCAGCCCCUGGGCCCUUACCUCCGCAGCCUCUCCCAGCAUCCAGCUACCCAGACUCCAAGGCCCCAGGCGAGAGCCAGCUCUCGGUACCUGGAGCUCCACAGGUCCCAGAAUCGGGGUGGAUCAGAGUUCAAAUUCUGGUUCUGCUACUGUCUAAUUGCGUGCUGCAGGGACUCAAUCUCUUCAUCUGGGAAAUGGGAGUAAUAACCCUUGGCAGGAAUGUUGCGAUCCUCUGGGAUGUCAGAGGUGUUGAUGAAUGUUAGUUCCCGGGACUUCGGAAAGAGGUCCCGUUGGAAGAGAUGUGAAUUGGAAUUCACACCCUAUAUUAAAAUCUCCUCCAAUCUUCACCUCUGAGACAUGGCUGUCUCAAGACUGUUUUGUUUCCCUUCCUGGUGGAAUUUUGCACUUUUAUGUCCUGUGUAGCAGCAGGUAGUGUGGCUUUGAGAAAAUAAAAUGGCCACCUUGCUCCGCUGUUCUUUCUUUGUAAAAAAAAAAAAAAAAAAAAAAAAACGGCAUAGCAAUCUUGGCCUUUCUAGCUGUGUGACCCCAGGCCGGUCAAUCCCUCCUCCUCUCCAAGCCUCGGAUUCCUCCCCUGAGAAGUAAAGAAAAUAACUCCUAAACUGCCUCCCGAGGCUUGCUGGCAGGAUCCAAGGUGUCCAGAGAUGUU

Taxonomic tree

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Expression New Publications