LINC00307: LINC00307 is a long non-coding RNA (lncRNA) that has been identified as having prognostic value in osteosarcoma [PMC8176230]. In a study using univariate Cox and iterative lasso Cox regression analyses, LINC00307 was one of 13 lncRNAs found to have prognostic value in osteosarcoma [PMC8176230]. It was expressed at higher levels in high-risk patients compared to low-risk patients [PMC8176230]. Additionally, the expression level of LINC00307 was negatively correlated with the levels of infiltrating neutrophils [PMC8176230]. In another study on gastric cancer (GC), LINC00307 was identified as one of the lncRNAs that may play important roles in the pathogenesis of GC [PMC6447923]. It was found to have significant positive associations with four pathways involved in GC progression [PMC6447923]. Furthermore, a risk score system based on an optimal combination of lncRNAs, including LINC00307, showed significant predictive effects and was identified as the optimal system for GC prognosis [PMC6447923]. References: - [PMC8176230]: Zhang, J., Zhang, J., Zhang, Q., Liu, H., & Zhao, Q. (2021). Identification and validation of long non-coding RNA prognostic signatures for osteosarcoma. Frontiers in Genetics, 12. doi: 10.3389/fgene.2021.660338 - [PMC6447923]: Liu Y., Zhao J., Zhang W., Gan J., Hu C. Identification and validation of long non-coding RNA biomarkers involved in gastric cancer prognosis. Oncotarget 2017;8:3725–3734 doi: 10.18632/oncotarget.13732