v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) prostate androgen-regulated transcript 1 (PART1) URS000075B1B9_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

PART1: Prostate androgen-regulated transcript 1 (PART1) is a long non-coding RNA (lncRNA) located on human chromosome 5q12.1 [PMC8053290]. PART1 has been found to play a role in various types of cancer. In non-small cell lung cancer (NSCLC) cells with wild-type KRAS, decreasing PART1 expression sensitizes the cells, but this strategy does not work in cells with mutant KRAS [PMC7293907]. In glioma, PART1 can suppress proliferation and migration through the miR-374b/SALL1 axis and inhibit tumorigenesis through the miR-526b-3p/IGF2BP1 axis [PMC9678906]. Additionally, lower levels of PART1 are observed in high-grade glioma compared to low-grade glioma [PMC7007780]. In hepatocellular carcinoma (HCC), PART1 is involved in cell migration and invasion, facilitating disease progression [PMC8202323]. Elevated levels of PART1 are found in esophageal squamous cell carcinoma and promote gefitinib resistance by binding to miR-129 to facilitate Bcl-2 expression [PMC6657684]. In gastric cancer, low expression levels of PART1 are associated with an unfavorable prognosis after surgery [PMC8291812]. Furthermore, PART1 can serve as a biomarker and therapeutic target in prostate cancer and bladder cancer [PMC6544013] [PMC6636221]. The function of PART1 is also investigated in intervertebral disc degeneration, where it influences cell viability, apoptosis, and extracellular matrix components aggrecan and collagen type II [PMC7751492].

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
AAACAGCCUCCUUCAAAAUGCAGCUUGACUGUGAUUCAUGGCACAAAGCUGGAAUAACCCUGCCAGUUCUUAGAAGCUUUAAGAUUCAUCGUCUUGAACUUGAUACACAUAGUAUAGCACCUUAAAAACGAAUCAUCUGCUAGUUCAGUAUUUUCUACUUACAAUCACUCCCUCCCAGGGCAUGUAAUUAAUUUACUGAGCUUAAAAAAAAAAUAUCAGGAUUACUCACACAGUCUUGAAGAUGCAAUGUCAGCUAUUUAGGACAGAAACAUCCAAGGCCGUGUCAGAACUCAAUUACGACUACAUAUGCAUUAAGGCAGGAACUGGCAGGCCUCAGGGUACGCCAACUAUAGGACUCGUGCUUCUCGUACGCUGGGCUAUAAUCUAUGAAACUGAGCUCCAGAGCCAGCCAAUCACUUAGCUCCUCAUAACAAGUCUAACUGGCUCUGGAAAGCUGAAAGGGCUGCACUGGAACAACACAGAUGAGAUAUUCUACACAUUAAUCUACUUAUCUGGAAUCACUUUGCCUCUAAAGGCCAGAGAAAAAUCACAGCUUCCUUGUCGGAGGGGAAAAGGACAGGUGAUCUGGGGAAAACGCAGCUACACCUGGAGCAAGGUCUCUUCCCGGCUUGGCAAUCUCAGCUGUGCCGGCGCUACGGGACCCGAGCCGUCCCAGAAACCAAAGGGCAGGCACGGCAGCAAACGCCUGAGCCUGCCUUGUACUUCAUGCAGGUUGAACAGAAAUGUUUUCUGAGCAUGUAUUGUUACAGCCCUCUGAGAUGGUAUAAAAGAAUGAAAGAAGACACGACCUGCCUUCCAGGAGUUUCACAAAAAAGAUGGGAUGAACACAGUGUUCACUUCCACCUUCCACCCUUUCACUAUGAAGGACCCUCACCAGAUGGUGGCACCAUGCUCUCGGACUUCCCAGCCUCCAGAACUGGACGGGUAAAUUGAAGCAAAAAGCAGACAAGUUCUAUGGGAUUUGCUGGCAUUGAUUUCCCAGGAUGGCAAAGUGCUAAGAACUAAACCUUUAAAGCUAACAAAAUGUACUGAUGUCUUUGCAAAGUAUCCAAGACCAACAAGAAAGUAAUUUCCCACCUCACCCUACCACCACCCAGAAAAGGAGCACAGAGAUGGGGAAGAGAGUGGCUGCAUCUGGCAUCCAGCCAGAGGAGUCCGUGCAGGGAUUCUGGAUCCCUCUUCCCCCACCCCACUGCCCUUCCCCCUCCACCCCAGCGUUUUGGAGAAGCAAGAAACUGUGAUGAUGCAGCUCCCUCAAGUAUCACAUGAAGAUAGUGGAAAGAGCCUCCUGAGGUAAAUAUGCCAUGUAGACAGAAACAAGCAAUGGCUCAACAGCAAUGUAUGAGGUCCAAGGACCAGGACCAAAGGGAAAAACAGCCAUCUCACCAGACACCUGCCUACGACCAGAUGCGUCAUCUCCAAUAUUAGCUAACUCCCUGGAACCUGGACUCAAGGUGUGAAAUAAAGGUUAAUGGGAAACCGCAGGAGUCAAAAGGAGGGGGCAGGAUUAUUGAGGAUUCAGGCUGUUGAGAAAUGAAAGUUUGGAUCACUCCCCAGAUAAAGAACCUUGACCAUUUAAGGGCAAUGGAAAUACAGAAUAGGCAGUAGAAGAAGGAAGCCAUAGAUACCAACUAUGGCCUCUCAAUCAAUUACAAAACUGAGAAUUCUGACAGUUUUGUGUAUUUCCUCUUUGCAUGUGAUGUAUAUGUGUGUAUUUGUAUAUAUUAACCAUUUUCCUUUUUCUCUCUUCAUUAUUUUAUGAAAGUUGUUGAAUAUAAACUCUACAAUUUAGCCUUUAGGUAAGAGAAUAUUCAGUGGGACUUUGAUUUGAGGAGUAUUUAAGACAGCCAGAUGAGACUACGAUAACUGUUGGAACUGUGUGUCUCCUCAUUUGGGGAAAGGGGUGAGAACUCUGCAUUUCUCUGAAGAACAGAGUUGACUUUGUGUUAUACAGAGUUCAAAUAUAUAUAUAAAAUGGUGCAUGUGGAAGCUAAGAAGCCAAAGGAGUUCACCAAGACAGUUAUCAAUAUAUUGCCUCUCCGCUCCAAAUCCACCCUUCUUUGCCCUGUUCCACGAUACUAAUCUGGCUCCUCGGUCAGCCAGUGCAAUGUCAUCUGUUGCUGGUAGAGUGUAGGGGAGACACUACAAGGUAUAGUAAAGGGGUCAGAUGCGGUGUCUCAUGCCUGUAAUCACAGCCCUUUGGGAGGCAGAGGCAGGAGGAUCACCUGAGGCCAGGAGUUUGAGACCAGCCUGGACAACAUGGUAAAACCCCAUCUCUACUGAAAAUACAAAAUUAGCACGCACCUGUAAUCCCAGCUACUCGGGAGGCUGAGGCAGGAGAAUCACUUGAACCUGGGAGGUGGAGGUUGCAGUGAGCCAAGAUCGCAUCAUUGCACUCCAGCCAGGGAAAAAAGGCAAAACUCUGUCUCAAAAAAAUAAAUAAAUAAAAUAAAAUAAAACAAGGUAUAGCAAAU

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications