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Homo sapiens (human) microRNA hsa-mir-219a precursor (hsa-mir-219a-2) secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-219a precursor (hsa-mir-219a-2) URS000075B0B0_9606

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MIR219A2: MIR219A2, a downregulated gene, is associated with clusters Oligo1 and Oligo2 in Alzheimer's disease (AD) [PMC6980793]. Oligodendrocytes in AD express fewer transcripts of genes involved in myelination, axonal guidance, and maturation of myelin-forming cells, including SEMA3B, STMN4, and MIR219A2 [PMC6980793]. MIR219A2 is a microRNA that plays a role in modulating oligodendrocyte differentiation and remyelination [PMC9822908]. It has been reported to be downregulated in the brains of Alzheimer's patients [PMC9822908]. The upregulated expression of microRNAs, including MIR219A2, in ALS-TD patients suggests transcriptional and translational dysregulation in these patients [PMC9822908].

Genome locations

Gene Ontology annotations

Sequence

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ACUCAGGGGCUUCGCCACUGAUUGUCCAAACGCAAUUCUUGUACGAGUCUGCGGCCAACCGAGAAUUGUGGCUGGACAUCUGUGGCUGAGCUCCGGG

Taxonomic tree

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This sequence is found in 32 other species

  1. Cercocebus atys microRNA 219a-2 (ENSCATG00000043195.1)
  2. Chlorocebus sabaeus (African green monkey) microRNA 219a-2 (ENSCSAG00000020154.1)
  3. Colobus angolensis palliatus miRNA (ENSCANG00000017178.1)
  4. Delphinapterus leucas microRNA 219a-2 (ENSDLEG00000013180.1)
  5. Equus asinus asinus microRNA 219a-2 (ENSEASG00005016200.1)
  6. Equus asinus (ass) microRNA 219a-2 (ENSEASG00005016200.2)
  7. Equus caballus (horse) microRNA eca-mir-219 precursor (eca-mir-219-2)
  8. Erinaceus europaeus (western European hedgehog) microRNA 219a-2 (ENSEEUG00000016154.1)
  9. Gorilla gorilla gorilla microRNA 219a-2 (ENSGGOG00000033097.2)
  10. Macaca fascicularis microRNA 219a-2 (ENSMFAG00000018189.2)
  11. Macaca mulatta microRNA mml-mir-219 precursor (mml-mir-219-2)
  12. Macaca nemestrina (Pig-tailed macaque) microRNA 219a-2 (ENSMNEG00000007311.1)
  13. Mandrillus leucophaeus (Drill) microRNA 219a-2 (ENSMLEG00000020285.1)
  14. Monodon monoceros (narwhal) microRNA 219a-2 (ENSMMNG00015011927.1)
  15. Myotis lucifugus microRNA 219a-2 (ENSMLUG00000017921.1)
  16. Nomascus leucogenys (Northern white-cheeked gibbon) microRNA 219a-2 (ENSNLEG00000019722.2)
  17. Pan paniscus (bonobo) microRNA 219a-2 (ENSPPAG00000000194.1)
  18. Pan troglodytes ptr-mir-219-2 (ENSPTRG00000027616.2, ENSPTRG00000051981.1)
  19. Papio anubis microRNA 219a-2 (ENSPANG00000027119.3)
  20. Phocoena sinus microRNA 219a-2 (ENSPSNG00000017587.1)
  21. Physeter catodon (sperm whale) microRNA 219a-2 (ENSPCTG00005015174.1)
  22. Piliocolobus tephrosceles (Ugandan red Colobus) microRNA 219a-2 (ENSPTEG00000011720.1)
  23. Pongo abelii microRNA 219a-2 (ENSPPYG00000021133.2)
  24. Pongo pygmaeus (Bornean orangutan) microRNA ppy-mir-219 precursor (ppy-mir-219-2)
  25. Pteropus vampyrus (large flying fox) microRNA 219a-2 (ENSPVAG00000026552.1)
  26. Rhinolophus ferrumequinum (greater horseshoe bat) microRNA 219a-2 (ENSRFEG00010018287.1)
  27. Rhinopithecus bieti microRNA 219a-2 (ENSRBIG00000015003.1)
  28. Rhinopithecus roxellana miRNA (ENSRROG00000009783.1)
  29. Sus scrofa (pig) microRNA 219a-2 (multiple genes)
  30. Theropithecus gelada (gelada) microRNA 219a-2 (ENSTGEG00000019604.1)
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