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Homo sapiens (human) cancer susceptibility 2 (CASC2) URS000075B07A_9606

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CASC2: CASC2 is a long non-coding RNA (lncRNA) that has been found to be regulated by berberine treatment and is upregulated in response to berberine treatment in various studies [PMC6357823] [PMC6625213]. It has been identified as an lncRNA that is essential for the anti-cancer effect of berberine [PMC6357823]. In the context of osteoarthritis, lncRNA CASC2 has been found to be upregulated and is involved in the regulation of IL-17 expression, chondrocyte proliferation, and apoptosis [PMC6522707] [PMC9061755] [PMC7294942]. Additionally, CASC2 overexpression promotes chondrocyte apoptosis and inhibits proliferation in osteoarthritis patients [PMC6958678]. In sepsis patients, lncRNA CASC2 expression is downregulated and it is negatively associated with disease severity, inflammation, and multi-organ injuries. It can also predict high mortality risk in sepsis patients [PMC9396177]. In colorectal cancer (CRC) cells, berberine treatment upregulates lncRNA CASC2 expression and promotes cell cytotoxicity by interacting with enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and silencing the expression of BCL2. This suggests that berberine exerts its anticancer effect through the upregulation of lncRNA CASC2 expression [PMC6625213]. Furthermore, low expression of CASC2 has been associated with a poorer prognosis in glioma patients [PMC8366401] [PMC5513825] [PMC6356972]. Overall, these studies highlight the diverse roles of lncRNA CASC2 in various diseases including cancer, osteoarthritis, sepsis, and glioma.

Genome locations

Gene Ontology annotations

Sequence

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AGCGGGCUGCAGGGCUGCGGGCGCUUGGUUCGGCCUGGCCCGGCCGGCGGCUCCUAACACCGGGCGGGCGGCUGCGGCGGCACUUCCGGGUUGGCCUUCUCCAUGUUGGUCUCGGGAACGUGAAGGGGCGGGGCCUCGAGGUCAGGGGUCAGCACCUCCCUGGUUGCCGUGGCGACUGGAGGCGCGCGACGCGGGCGCAAUGGCGGGGACCCGGGGCUUGAUGCUGCUUGGGCCUGGCCCAGUGGCGGGUCCUAGGGACGUGGGUACCUGCAGAGGCCGGCAGAUGGAGAUUCAGAAACAUAAGGACAACAAGAAACUUCCCCAAGGUAUCAUUAUAGUCUUUAGACUUCAGACACACACCACACCUCAAAUAUAUACACAACUGAAAGGAAAAUUAAGGAAGUUUUUCAAAGAACCCUAUUCCGAGUAAGAAGUGUGUUGCAUGAAUUUCUAAGAGCCAGAAAAUGCAUGACACAGGAGAAGAUGUACCCUCAUCUGUUCAGUGAGAGAUGUGCAAAUCAACAUCAACACAGAACUGCUGAAGAAAAAAAAUAUGUCUCUGAAAAGCAACUUAUUCACUGGAGAUGUGAGGAGCCAUCCGCACAUCACAAUUCUAUAGACAUCAAACGCAUGAAGCAUUUCGGAUCUGCUUUAAGACUGAGGCAGACUUUCCAUCUGGACACAGCCGACCAUCCAUGUGUCAUUACAAUGAAUCCAGCACUUCCCUGGAAGCUGGAAGGGUCAAAUUCAACUUCAACUCUGCCACUUCCUGCUUAACUUGCUGUUUAACCUUGGGCAAGCUGCCAUCCCACACGAGGCCGAAGGUGUCGGUUUUUAAAAUACAGAAAUUUGGUUCCAUGAGGGAUUAUCAAUAUACUGCUGGUGGGCCAAAUUCCAUCUGCUACUUGCCUUUGUAAAUAAAGUUUUAUUGAAACACAAACAUGCCCAUUAGUUUACUCUUGUCUGUGACUACAAGGGCAAAGUUGAAUAGUUGUUACAGAGACCAUCAGGCUCACAAAGCCUAGGUUAUUUACUAUCUGCCCAUUUACAGAGUAAGUUUGCCAGCCCUGGACUGGAUAAUUUUUUGAGUUCUUUCUAAUUCUAGAAUUCUUUAUAUAUUUUAUGAAACCCCUAAUGUUUAUAUAUUAAUUAUUUCAAUACCCGUGUCUUUACUGAGUCCCUCCUAUGAAGCAUACAUCAAGACAUAUGUGUGAUACAUUAACUAAACUUUUAACAGUAUCUUAAAUAGGAUUUCAAUGACUAACAGCUCUUGGAAAUAUCCAAGGUAACAUUUGGGGGCAAAUGUCUUAUGAUUUGAUUAUCAUUGGUAAAUAGAGCAUAUCUUUUUUUCCACUAACAAUGUUUAAGAAGUUAAAAAAAAAUCAAGAAAACCCCGUAUGGCACUAGAGACUUAUUGCAUUAAGACAUCAUCUUAACAGAUUGUUUAGUUUUGGUAAUAUAAUUUGACAUCUAAACAUAAGCUGAGAGGGAUCUCCCUCAAAACCUUUGAUAAUAUGAUUCAUUGUCAAAUGUUUGUUUUGCCUAUCUGGCACUCAUUAAUUAAUUCUUUUUAAUAUAGCUUGGAUUUACUGAUUUUGAAAAAGAGAAUUAUUCUUAUUGAUGUUGCUAAAAUAUCCAGGUGGCUUGAAUUUCACCAACUAGAUAGUUUAAUCUAGCACAUUUGUGUAGCCCUAAUCAAAUCUUUACUAACAGAUGUGAGAAGCCCAGUACUGGAGCUAAUGUUUGUGUCUCAAUGAUAAUUAAAUUAGCUUAAUAAGGAAAAUAAAUGAACAAUAAUCACCAAAAUUUUUCCCUAAACCUGUGUUAUAGUCUUAAAAACAUUUUUUCCCCUAUGGAGGCUUUUGGUAAUAAAACACAAAUUGAGGGAUUUUAAUUAAAAGAAAUUUUUUUUUCAAGAACUGGUCAUGUACUAAAUUGCUUAUAAUCAAAUAAUCAAGUAGCAUUUCUUUUAUUAUAAGAGCAAAACCUAUAAUUAAGCCAAAAUUCAAAUUUGUUUUUAAAGGUUGAAUAAUCUUUUGUUUUGGCCAAUAGUAUGUGGAUUUUUUUUUUAAGUAUUAUCUCUUUGUAGUAUUUUCUAAUGGAUAGGAAAUGCCUUUCUCAGGUUGAAUGAUUAUUUCCACAUAGAAUUAGUUCCUGCUUACAACAGUGCUCCACUAAUGUAAUGGCUCGGUGAAUUGGCUUUAUAAUUCAUUAAUCAUAGCUCACAUUGAGCUUUUGGCUCCAGGUGACAGUGCCCACCACAGGCCAAAUAACUUCUCAUUUAAAGGCAAUUUGUACAAAUAGGGAAGGUGAGAAUUCUCACAGUCCCAGAGGGAUUGAAGAGUUUUAAAAAACCAAGAUAAGGCAUUUUAUGGAAGACAGGUUGAUGGAAGAAAAGUGGCCAUUGGAGGAUGAGGCAGAUGGCUUUCCAGGGAGGCCCUGGAGCUGCCACCAUGGGGAAGGCCAUGUUGCAGCUGCUGAUCAGAGCACAUUGGACGGUGUUUCCGUGUGAACAUGAAGACAAUGCUGCCUCUGUUUCUGUGACGCUGUGCUCUGAUCUUGCUGGAGGCGAAGUGGUGUCAGCUGUGCUUACAGGACAGUCAGUGGUGGUAGAAAAGAGGCCAGUGUGACCUGUGAAGGACUGGGCCCCUCUCACUCAACCUGAGUGCCUGCAGUUGUGGCCACCUUUAUUUGUGUAUUCUACUGUAUUUAUUUAUUUGCCUGGCUAAUUAGCUCUGUGCCACAUUCCUAAGCUAGAUGUGUCCCUUCAUGUAAGUGAGAGGGAGACAGAAAGAAAGACUGAGGUGGGGGGUAGGAGAAAGAGAGGAAAGCAAGCAAGAAGAAAGAGAAAGAGAGAAGAAGAAAGGAAGAGGAAAGAAAGAGAGAAAGAGAAAGAGAAGGAAGGAAGGAGAAAGAGAAGGAAAGAAGGAGCCUUCUAAUUUUAUUUCAUUUCUCCAAUAAAUGUUCCUAUAUUAAGACUUUAGACAAAGAUUAGAAAUAUGAUUUGACAGAAAGUGUAUGGAUGUGUUGUUCUAUUGCAUUGUAAGUAAAGUAUCCAUGGCAAUAUACAAAUAAUACAGCUCCUACCCCUAUUCUCUGUUGUUACUUUCAUGUGUUGUCUUAACUUUUUAAAUUUCAAGAUAAUAUUGCGCUUAUUUAUUUUUCCAUGAGGAGGCCUAGGAUUUAGCUUGAUUAGAAAAGCUGUGGAAAAUGAAUGUGCUAAUUACUUUAAAUCAAAUUGAAAAUAAAUUUUAUCCUGUUUCAUGCAAAACAAAAAAAAAAAA

Taxonomic tree

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Publications