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Homo sapiens (human) EP300 antisense RNA 1 (EP300-AS1) URS000075B03B_9606

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EP300-AS1: EP300-AS1 is an up-regulated ERAR lncRNA gene that is significantly associated with poor prognosis [PMC8994511]. It is a 1,405 bp gene with three exons and is the antisense transcript of the protein-coding gene EP300 [PMC4991000]. EP300-AS1 has been found to be correlated with 30 protein-coding genes and has been identified as one of the top predictive lncRNA genes in breast cancer [PMC4991000]. In breast cancer, EP300-AS1 acts as an oncogene, while its paired protein-coding gene EP300 acts as a tumor suppressor [PMC4991000]. Higher exposure to prenatal stress has been associated with reciprocal patterns of epigenetic regulation between EP300 and EP300-AS1, suggesting a potential synergistic effect in future studies [PMC6507133]. In lung adenocarcinoma (LUAD), down-regulation of EP300-AS1 has been observed, indicating its potential tumor suppressor role in LUAD [PMC9664164]. Additionally, EP300-AS1 is one of the four lncRNAs (along with LINC00857, TBX5-AS1, and SNHG3) that have been used as diagnostic biomarkers for LUAD [PMC9664164]. The expression levels of EP300-AS1 have also been found to be distinctly different between cancerous and para-cancerous tissues in LUAD patients [PMC9664164]. Furthermore, EP300-AS1 has been identified as one of the differentially expressed lncRNAs associated with ferroptosis and can serve as an independent prognosis predictor for head and neck cancers [PMC8950679].

Genome locations

Gene Ontology annotations

Sequence

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CCAGCGCGUGCCCGCCCGGCGCCCUCUAGGGUGGAAGGCUGCGGGCGUCCUACCAGUGCCAGGACUGCCAGAGCGGGAGGAGCGCGGCGCGGGCCAGCCGGGACUGCUGGACAGCGGGGUCCAGGCUAGAGGCGAGCGAGCGGUCAGUGACGGCUGUGGAGGAGGGAGGCGCUGGGCGUCAGCGCGGGACCCGAGCCUCUGGACCACUGAGCUGGGGGGCUGGCUGAGGUCCACCUCCUAACAAAUUAUUGGAAGGAAUAUGAGAAAAAUGGAGUUUCACUCUUGUCACCCAGGCUGGAGUGCAAUAGAGCGAUCAUGGCUCACUGCAACCUCUGCCCCCCGGGUUCAAGCGAUUCUCCUGCCUCAGCCUCUCAAGUAGCUGGGAUUACAAGUGCCCACCACCACGCCCAGCUAAUUUUUGUAUUUUUAGUAAAGAUGGGGUUUCACCACAUUGGCCAGGCUGGUCUCUAACUCCUGACCUCACGUGAUUCAUCCAUCUCAGCCUCCCAAAGUGCUGGGAUUACAGGCAUGAGCCACUGUGCCUGGCCUAUACUUAUAUUUUCUUCUGUGAUUUUAAUAUUUUAGUGUUUAUGUUUUGGUCUAUGAUCCAUUUUGAGUAAAUUUUUAUAUUUGGUAUAAGGUAGGGGUCCAACUUUAUUUAUUUUUGAGAUGGAGGCUUACUCUAUUGCCCAGGCAGGCAUGCAAUGGUGCGAUCCAGCUCACUGCAACCUCUGUGUCCCAGGCUCAAGUGAUUCUCCCACCUCAGCCAUCUGAGUAGCUCGGAUUACAGGCCCCAUCACUAUGGUAAUUUUUAAAUUUUUAGUAGAGACGGGGUUUCACCAUGUUGGCCAGGCUGGUCUCGAACUCAUGACCUCAAGUGAUCUGCCCGCCUCUGCCCUACAAAGUGCUGGGAUUACAGGCGUGAGCCACCGUGCCUGGCCUCCAGCUUUAUUCUUUUUUUUUUUUUUUUUUUGAGACAGAGUCUUGUUCUGUCACCCAGGCUGGAGUGCUGGAGUGCAGUGGCGCGAUCUCGGCUCACUGCAAGCUCCGCCUCCUGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCGAGUAGCUGGGACUACAGGCGCCUGCCACCACGCCUGGCUAAUUUUUUGUAUUUUUAGUAGAGAUGGGGUUUCUCCAUGUUAGCCAGGAUGGUCUCGAUCUCCUGACCUCGUGGUCUGCCUGCCUCGGCCUCCCAAAAGUGCUGGGAUUACAGGCGUGAGCGACCAUGCCCGGCCAACUUUAUUCUUUUAGAUGUGGAUGUCUAGUUGUUCCAGAAGUAUCUGUUAAAAAUGUUACUCUUUCUCCAUUGGAUUAUUUUGGCAACCUUAUAAACAAUCAAUUGACCAUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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Publications