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Homo sapiens (human) FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) URS000075AEF0_9606

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FOXD2-AS1: FOXD2-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including osteosarcoma, papillary thyroid cancer, bladder cancer, glioma, and non-small cell lung cancer (NSCLC) [PMC9161975] [PMC6695468] [PMC6463795] [PMC5833400] [PMC8610140]. It has been shown that high expression of FOXD2-AS1 is associated with poor recurrence-free survival in thyroid cancer patients and poor prognosis in glioma patients [PMC6463795] [PMC7711959]. FOXD2-AS1 has been found to act as a ceRNA to increase the expression of KLK7 through sponging miR-485-5p in papillary thyroid cancer and to abolish the effect of curcumol on glioma resistant to TMZ [PMC6695468] [PMC8610140]. In addition, FOXD2-AS1 has been shown to be associated with bladder cancer progression and hypermethylation of the MGMT promoter in human GBM cell lines, resulting in decreased MGMT mRNA and protein levels [PMC5833400] [PMC9466271]. It has also been found that FOXD2-AS1 is present on exosomes and significantly higher expressed in smokers and non-small cell lung cancer patients. Furthermore, FOXD2-AS1 has been implicated in the regulation of various signaling pathways such as Notch signaling pathway and Wnt/β-catenin signaling pathway in different types of cancers including colorectal cancer (CRC), hepatocellular carcinoma (HCC), lung squamous cell carcinoma (LSCC), gastric cancer, cervical cancer, breast cancer, renal fibrosis models. It also interacts with miR185-5p to inhibit cell progression and improve sensitivity to cisplatin. Moreover, FOXD2-AS1 has been found to regulate the expression of miR-185 in Bel-7402 cells and to inhibit the PI3K/AKT signaling pathway in breast cancer cells [PMC8383050] [PMC6929557] [PMC8643235]. Overall, FOXD2-AS1 has been identified as a potential therapeutic target and biomarker in various types of cancer.

Genome locations

Gene Ontology annotations

Sequence

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CCUGUUCGGCGUCUUGCAGCAGUGCCUGCGAUCCCGCGUGAGUCCGUCGCUCCCUCCGCGAAAACCUGGACUCUUUCCCAGAAGCCUUGGGCUCCAGCACCAUGCCUGCUGCAGCCGCCAAAGAGCGGGAAGCCACAGGCUCUGCGGGUCUUGGUUACAGCGUCUCUGGUCGUGCCGGGCCUCCUUCUGCAUCUGUUCCACGGCCCGGCCAUCUCCCUCGUGCAGCCCAGAACAAUUGGGAGGAAGCGUUGGCGGGCGGAGGGGGAUGCCUGUUGGGCUUUUCCACUAGUUACUGAGUGUUUUUUGCGAAGAGUACGUUGCUAUCAGUGGCGUCCGGGUCGUCUCUCCCUCUCUUCCUUUUGGUCCCCAUAAAUGAGCUGUUCUCGGCUCUGGGAAAGAAAAGCCCUCCAGCGAUUAUGCGGAUCUAAUUAAGUCAAUCAGGAAACUGCCGGAGAGCGGCACUGGCUUGAAGCGGAGUUUGUCCUGAGGCACAGCGGAACGAUUGCACGCGGCCCUUUUCAGCGGUUCGAGCUCGGCCAGCGCCGGGCUGCAAACGGAAGCCUGAGCUGGGCUUGGGGAACUACGCCCGCAGAUUUCUCUAAUUUUAUUCACAAAACUGGACACCCUCAGGGAAAGCGGCAAAGCCGGCGCGAGCCUCCUUCCCACUCUGGACCUAGCUGCAGCUCCAAAGCGAGAUAGCUGUCUAGCCUCAGCCGGUACAGCUCCCGGCCCCUUUCUCCACCCGGAUCUUCGGCUGCUCAGAAGCGAUCAGCUCCCUUAGCCCAGGUGGGAGGCGGGAGACUCCAGAUCCUGUGACCCGCGGAGGCAGACCUCAGACAUGUUCCCCAUGCACAGAAAUGACUGGGGCUCCAGUGUGUGCACCUUCAACUCUGAAGCCCACCUGCCCACUUCAGGCGCUGGCGCGGAGAUAACCACCACGCGUCUGCCGGGCAAAGUUCGAGAGUGAAUUUACAUCUUCUCUUUCCGCUACUCCUGGCCACUGUCCCCUCCCAGCCCCAUCUCCCCCGCCCCCAACCCUGGACUAUGUGGUAGGGGACUCGCUUAAGCACCCAAGUACUGCGCGGUUGUUGAGACCAAGGCGAGCUGCGGAGCCUGUGGGCUGUUGUUCGUGGGAAGAGGGUUGCGACCUCAGGAGAGACCGAAAACAGCGCCACUUGAAACCCGCCGGUCCUGAAGAUCACAGAGUUCCCGGAGUGGUAGGGAAGGCUCCACGCUCUUGAGAGCAGAGGCGGCCAGGGGCAGUGGGGGACGCUUCCAGGUAUGUGGGAAGGAGAACUUCAUGUCUAAGUGCGCUCUUGUGGGUUUCUCGGCCAGCUGGGCCGAGCCUCUCUUUCUCUGUCCUCAUGUGUCUGUCCUCUGGACAACAGUGGCUCUGUAUGGCGGAUUGCGACCCUGAGUGACGGGCGCCUGUCUUGCAUCCUGUGUCCUGUGUCCUCCCCUCCAGACCUCAUGCUUGGUGUCCACAGAGUGGACCCAGGACUGCCUGGAAGGCUUAUCAUCCAGGCCCGCGACUUCCCCCCAGAGUCUGAAGCCUUGCGACCUGGUCGGGGACGACAAACCUGCUCGGGGUCAACAGCGAGACCCUAGUGGGGAAUGAGGAUGGGUGAGGGUGCGCCUGGGUUGAGGGUCUGUGACUGUAGCAUGGAAAAGGAGUUCAUGCAGGGAUCGCACUGAGGGACAGCCAAGAAUACUCCAGCGGCAGCCUCCCUCCUACCAAUUACACGCCGCCUGCUGGCACAGUGGCACCUCGGGAACAGGACGCCCUUCCGGGCCCUGAAUUGGGGCAGCGCAGGAGGGAGGGUGCAGAGCCAUAGCGACCUGUGUGUACCAUAGACAUGCACAUGCGCUCACCUUCACGUGUAACCCUUCUGAGUCCCAGACAGGGUAACUGGCGAGGCCGUAAGUACCCUCGUGGGGGCGGAAAUAUUGCCGCGUCCCUGAGUCCUCUGGGCAGAUGCAGAGCCGCGUAAGCCUCAUAGAAGCAAAGCCAGGGGAACAGUGGGAGCUCUGGCCUCGCGGUGCGGACGCUAGUAAUGGAUUCCUGGGGAACAGCGACCUCUGGAGGAGCCUCUCAUCCACACAGAGUCAGGAACUAAAGGACUGGUUCUGAGACAAAGCACCCUUUCCUCACCCUACUCCCAUUCCACCCGCUUGGAAAAGUUAUCCAGAGACUUUUAACCUCCGGACUCCACUCUUCGCUUAUGUUUGCUUUUUUUUCCAACCUGUACCCACGCUUCAAAAUCCCUGCUCCAGUCCUGCCUCUUCCAGAAAGAAGCCUUCUGGCCAGCCCAGUUCCUCUUCCCCUCUUCCUGUUCUGAGCUCAUUCUCAGGCCACACUGCACAGCCAACCUGCUUCCUGCCUGCUCUUCUCCAAAAAGACUGUGAAUCCACUCCACCCACGCCUUGUGUUGCAUGCUGGGCAUGCCGUUCCCUGCCCCAACCCACCCCACCCCCCAGUGAAUAAAGACUGAAGUUAUUCAUUCCAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications