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Homo sapiens (human) long intergenic non-protein coding RNA 857 (LINC00857) URS000075AEB1_9606

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LINC00857: LINC00857 is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including ovarian cancer, breast cancer, colorectal cancer, lung cancer, and pancreatic adenocarcinoma (PAAD) [PMC8275123] [PMC7932076] [PMC8012143] [PMC6051137] [PMC9498830]. It has been shown to promote glycolysis in ovarian cancer by upregulating YAP1 and enhance the expression of lncRNA BCAR4 in breast cancer, which coordinates the Hedgehog pathway to upregulate HK2 and PFKFB3 [PMC8275123]. LINC00857 is also involved in the TGF-β pathway and Hippo signaling in cancer glycolysis [PMC8275123]. In colorectal cancer, LINC00857 has been studied to explore its function and mechanism [PMC8012143]. Additionally, LINC00857 has been suggested as a potential marker of chemotherapy response in bladder and other types of cancers [PMC6051137]. Bioinformatics analysis has indicated an interaction between LINC00857 and TFAP2C, a transcription factor that is upregulated during the transition from primed to naive cells [PMC9807510]. Knockdown of LINC00857 has been shown to suppress tumor progression in lung cancer by inhibiting cell growth, migration, and invasion [PMC8012143]. Furthermore, LINC00857 is involved in cell proliferation as well as apoptosis and autophagy processes; however, the exact mechanism is unknown [PMC7701017]. In pancreatic adenocarcinoma (PAAD), the association between LINC00857 and PAAD remains poorly explored but warrants further investigation[ PMC9037484].

Genome locations

Gene Ontology annotations

Sequence

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GACCGCGAAGGCCAGCUUCUUCGAAAGGCCCAUUUUUCUCCGUGGCUGAGCGAAUGCUCCUAGAAUACCACGUUUAUAAUAAAUCAUGUAGGGUGGAAUUCCUGCUGGAUGUAUACACCUUUCUGCAUCAGAGCUCUUCAAACCCAGAAUGGUGAAUAGCUACCCCUGGGCUUACCCUUUUAUAAUUUUCAACAAACCUGCGUUUAGCCCCGGCUAGGUGCCAGCAAGUUGCUAGGGACUGAGGAGGCUCUGCAGAGGACCCGAGCUGAGGCCCUAAUCCUCAAGGCCAAUGGCAGGGGUCACCGCCCAGGCACCCCCAGAGAACGCGGUGUGAAGGAAAAGACACCAAACUCGGUGUUCAAAUGUGUGGGAUCUAUUCUAGUUCUGAUUCUGACACUUGCAAGUCAUGCAUCCUCCGAGCCUCGGCUUUCUCACCUAUAAAAUCUUCAACGUGACCUAUAAAAAUCCAUAAAAUCACCCCUGCUUCAUUGUUUCCCAGGGCUCAUAGAAACAUCAUACAAGGUGGAGAAGAGUACCCAAGAAGGACAAGCUUGGAAUGGGGCCCCCUCCCCAGGCUGGAGAUCAGACAUUGUUGGAGAAGGUAUCAUUGCAGCCCCCUACAUAGCAGAGAGAUUUGCUGAGUUGCAUAGUCUAGAGCUGGUUGCAAUUAUUGGACAAGCAGGAAACAAACCUCCACAGCCCAUGCGAGCCACACUGCUGGGUUGAGUGUAUGAGCAUGUAGAAUGAUUGGGUCUCCAGUGCGGACAGAAGGCAUGGAUCGCGUGGUGCCUGUGUUGGGAGGAUACUAAGAGGGCGAUCACCAUGCCAGGACAAGACUAGUUGCCUGGGAUCUUCUGGGCACGUGACUGGAGCAGAGUACCACUGGAUCUCCUCACACCAGCCAGACCCAGGAAGAGAAGCUCCUUUCACCUGCACUGUUCUCUCAGCACCCUCCACGGAGAAAGCUUCAUGUUAUGCUUAGUGUACAGGAGAAAUGCUCAUGGGAAUCCUGUCCAUUAUCACAGAGCAGGUAUUAGUGGGUGAAUAUGGAGCUGAGAAGUAAUAAGUUGUAACUGGCAUAGAUAUCAUGGGGAUAUUUGAAGAACGCUGUGAACACAUAUGCAUGGGUCCAUGUAUUCAUGAGUGUGCACAUAUGUGUAAUUAUUCAUACAAUUCAUGGUGGAUACUACUUCGAGGGUGUUCACAGACCCCAGGCAGAGAGCGCCUGGAGGGAAAAUUAUCCAAGGCAGGCCCAUUCAUAGUUCCAGGACAGCCAGAAGAAAGCCUCCGUUAAGCACCAGAAGUCUCCGGGGCAGGUGGGGCCAGGCAGCAUGAAAGAAUUGGCCGCAAGAGUUCCAAACCCUGUCCCAAUUAUGGAGGGUGACUUUUCUUUGUCCUCCUUCUCCAUUCCCUUCCAUAUUGCUCAUGCAUCCAAAGGGAGACCUGAAGACUCUCUAGCAGGGCAAGGCCAUUUUCUUUUGGCAUUUUUCUCUCCCCAGAGUCUAGCUGAUUAUCAGCUUAGACACACAGCAGGCUAUGUGCUGUGAACAACAGGCAUCCUGGGUUAUUUUACAAACUCAUGGAUAGUCAUUUUGAAACCACCUUUGCAAAAUUGUGACUGAAACAGUGAAAGAGAGCUAACUUAACCAGCUCCAUCUUGUUUCUAACCUCCAAGCUGUCUUUGUUCAUUCCUGGGCGUAGGCUGAACUAACUUUGGGAGAAACUUAGUUUGUAGUUAUAGUUUAAACAAAGACUGUGACAGCCCUUUCCCAAUGCAGACCUCCUUCUUGUCUGGGGACUAGACUAACAUUAGCCACAGGAUUAGAAAUUACGGUUUAGGAGUCACGCAGCUGGAGGCUACAAGAUUCUGACCCUCCCUAAACUGCUUCUAAGAUCAGUGCUUGAGACAUGUUGCAGACCCCGCACUUGCUGGAUCAGCUGACGCCACACAGAUGGAUAAACUGCCUCGUCUGAUCUUGUGGCCCCCACCCGGGAACUGACGAAGCGCAAGAAGACAGCUUCGACUCCCUGUGAGUUCAUCCCUGACCAACCAGCACUCCUGGCUCACUGGCUUCCCCCUACCAAGUUAUGCUUAAAAAUUCUGCUCCCCGAAUUCUCGAGGAGACUGAUUUGAGUGAUAAUAAAACUCCAGUCUCCCGCAAAAAAAAAAA

Taxonomic tree

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Publications