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Homo sapiens (human) PDCD4 antisense RNA 1 (PDCD4-AS1) URS000075AE47_9606

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PDCD4-AS1: PDCD4-AS1, a long non-coding RNA (lncRNA) transcribed from the complementary strand of the PDCD4 gene, has been found to be down-regulated during breast cancer progression and its expression is positively correlated with PDCD4 level in breast cancer tissue [PMC9251513]. Silencing the expression of PDCD4-AS1 leads to the inhibition of miR-30b-3p expression and overexpression of METTL7B [PMC10162875]. PDCD4-AS1, along with other lncRNAs, has been reported to play a critical role in cancer progression and is used in risk signature analysis [PMC8497898]. Depletion of PDCD4-AS1 using modified antisense DNA oligonucleotides also results in reduced levels of PDCD4 mRNA [PMC6289468]. Additionally, the expression of PDCD4-AS1 is associated with overall survival in triple-negative breast cancer patients, as shown by Kaplan-Meier analysis [PMC7704410].

Genome locations

Gene Ontology annotations

Sequence

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CACACACGCACACACACACACACAAACCUUCACUGGCUUCCCAUUGCCUCUCUUGAGUGUCAGCGCCUCGGUCGGUCAUUCAAGGCUCCGUGAUGUGACUUCAAGACUUUCAGGCUGUGUCUCCACACAUCUCCCCAUAUGCUUCCUCACCCCCUGGUAGUUCUUUAUAUAUCACCUUGAAAUGUCUCUCUUCUCAUCUCCUAUCUCCGCCUGAUGCAAUCCUUCUGUGCCUCAUGGCCCUUCCUGGUAGUUUUUUAUUUUGUUGUUGUUGUUGUUUUAUUUAAUUGAGGCAGGGGCUUGCCCUUUAGCCCAGGAGAAUGCAGUGGCAUGAUCACAGCUCACUGCUGCCUCGACCUCCGUCAGCCUCCCUAGCUCAACGAUCCUCUCACCUCAGCCUCCUGAGUAACUGGGACUACAGGCACAGCUCACUAUGCCCAGCUAAUUUUUGUAUUUUCUGUACACACAGGGUUUCAUCAUGUUGUCCAGGCUGGUCUUGAACUCCUGGGCUCAAGCAAUCAGCCCACCUCUGCCUCCCAAAGCGUUGAGAUUACAAGCGUGAGCCACCAUUCCUGGACCCUCGUAGUUUUUCUGGAGCCUCGUGAUUUGAUAUGAUCUUCCUGCCGCUGAUUCCUCACAGUGUUGGCUUGCCACACCUCCAGGGGCACUGAUCACAUUCUACCUGGCAUUAUUUCAUCUGAGUCCCUGUCCUAGCCCUUCUGCCCAUUAGACUGUAACCUUGUUUAGGGAAAGACCUGUGUCUUACUCAUCUGUGAUUUUGUUGUUGUUGUUGUUUUGAGACAGGGUCUUGCCCUGUUGCCCAGGCUGGAGAGCAGUGGUGCAAUCUUGGCUCACUGCAGCCUCAACCUGUUGGGGUCAAGCCAUCCUCCCACCUCAGCUUUCCAAGUAGCUGAGACUACAGGCCUGUGCCACCACACCCAGCUAGUUUUUUGUAUUUUUAGUAGAGAUGGGGUUUUGCCAUGUUGCCCAGGCUUCUCUUGAACUCCUGAGCUCAAGGGAUCUGCCUGCCUCGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGCCACUGUGCCUGACCCACUCACCUGUCAUUGUAGUACUUAAGAUGCCUUGUUCAUUUAUUGUGCCUGUGCAAUAAAUACACCUUGAUUUGAGUUUACAAAGAUUCUCAGCAGUUGGUGGUCAUCCUCAUCUCCUGGGCGGGGGCCUCCUGGUGUGGCCAGUAUCUGAAUUAGUCUCAUAACUCAUGUUCACUUUUUAAAAUCGGAGCUUCCCAGACCUCAGUUUUGUUUUGUUAUUUUCCAUUAUCUGCAGCUGUCUCCUUUCCCCUCUCUCACCUAUACUCUACUGAUCAGUGACUGCUGGCUCCUUUGUUACCCAUCCUUCUCUUUCUCCACAUUUUUUCUCUUCUCAUCCCUUUCAGUUCUGGACUGUUUCCUUCUUCCUCCCUGUCUUUCAUUUAGUCAUUCAUUGAAUGUACUUACUAAGCACAUAUAGCAUAAUCAGGCUGUGUUGGGUAGGCAUCCCGAGUUCUAUGAGAUAAAGAAAGAAUGGGAUAUGAUUACCAAUUUUAAGAAGCAUCUAAAACAACCUGUUAUGUUUUAGCAAAUUGCCCCCAAAGGACCCAUUAGGGAGGAAAACGUUCAUGUCCUUUUUGCGUAUCAUCUCAAGCAGUACCCAUGAUGGCUGGGAUCCCAGAACCCACCUUUGAGAAUGCUGCCGUAUUUGCGUGUGGUUGACAAGGUUGGGCCAGACACUCAGGAAAUAGGGUUGUCGUCCUACCUCCCCCACUAACUUCCUGUAAGAACUUCAGCCCCUCUCAGGACCUUUUUCUUUACCAAUAAAAUUCAGAAAUUGGGCUCAAUCAGUAAUUCCCAAGUUAUUUUCCAAAGAACAUGAAUUUUGUGGAACUUUAAUAGAUAUCAUGCAAAAAAAAAUGUGGGAGGGAUUGUUCCAUGGUCAAAUGGUCUUGGAAAUAACUCGUUUAAACAAAAAUAAAACUGUUUCUUUACCCAC

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Publications