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Homo sapiens (human) long intergenic non-protein coding RNA 467 (LINC00467) URS000075ACB7_9606

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LINC00467: LINC00467 is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including acute myeloid leukemia (AML) [PMC9585262]. It is associated with young age or high white blood cell (WBC) count in AML patients [PMC9585262]. In glioma cells, LINC00467 is found in the cytoplasm and may play a role in post-transcriptional regulation [PMC8973818]. It has been proposed that LINC00467 can inhibit p53 expression in the nucleus by binding to DNMT1 and promote IP6K2 expression by binding to miR-339-3p in the cytoplasm, thereby promoting glioma growth and metastasis [PMC8973818]. The regulatory mechanism between LINC00467 and AKT3 is not fully understood [PMC9198549]. LINC00467 is highly expressed in bladder cancer tissues and functions as an oncogene [PMC8194349]. It may recruit DNMT1 to mediate Reprimo expression [PMC9276005]. In lung adenocarcinoma, LINC00467 plays a role in tumorigenesis through the activation of the Wnt/β-catenin axis by knockdown of dickkopf WNT signaling pathway inhibitor 1 (DKK1) [PMC8810099]. LINC00467 has been shown to regulate the expression of various genes and miRNAs. It can reduce the expression of its neighboring protein-coding gene RD3, while N-Myc suppresses RD3 gene transcription through direct binding to its promoter region [PMC3929584]. The transcription of LINC00467 itself can be regulated by N-Myc as well [PMC9198549]. LINC00467 has been implicated in multiple signaling pathways. It can increase the stability of NF-kB-p65 and promote its translocation into the nucleus [PMC8194349]. It can also regulate the expression of miRNAs such as miR-128-3p and miR-7-5p [PMC9275949] [PMC8810099]. In gastric cancer, LINC00467 knockdown upregulates miR-27b-3p, which suppresses malignant phenotypes of gastric cancer cells by reducing STAT3 expression [PMC8898310]. Overall, LINC00467 is a versatile lncRNA that plays important roles in various types of cancer through its interactions with different molecules and signaling pathways.

Genome locations

Gene Ontology annotations

Sequence

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GUGGCGUAGGCCGGACAUUUCUAGUCGACUGUUGCGCGUGCGCGCGCUGUGACGUUCCCUACGCGGUCGGGCGUUGGGUUUCGCGGCGCUCGCCGCACUGGUUGUUCAGCACCUUCGGUCCGGUUGAGGUUGUCAAGUCGGACCAAACAGGUUGUUUCUCUGCAGUUUCCAACAUGGCAGGGAGGUUUAAUAGACAUGGAUAAGAAGUCCACUCACAGAAAUCCUGAAGAUGCCAGGGCUGGCAAAUAUGAAGGUAAACACAAACGAAAGAAAAGAAGAAAGCAAAACCAAAACCAGCACCGAUCCCGACAUAGAUCAGUGACGUCUUUUUCUUCAGAUGAUCCUAUGUUUCCUUCUUCCUCAUCAUCGUCUUCAGGAAGCCAGACAGAUUCAAGUAUUGAAGAUGCUGCCAAGGGAAAAAUUAAGAAGAAGAGAAGAGAGAAAACAAAUAAAUGGGAAAAAAGAAAGGACAAAAUAUGAAACACCAAGAAAAAGAGAAGGAAAAAAAGGAGGAAACAACCACAUAUGUCACCUUUCCAAGAGGGACUGAAACUGGGCUGACCCUUUUGAUUUCCAAGCUCAGCGUUUUGGUGUAAGGCGGCCAAAGAAGGAUGCGGAGCCCAGCACUGUGAAGCCUACAAAAACAUUGAUGCGCUGGCUUGGGGAUUUGAAUUUGAACAUCUUUCACACUAAGUUCAGACUCAUGAAACCAAUCUUCAGAUGCUCUGUAAACCACAUAAUAAAGAGUUUGGAAAUUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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Publications