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Homo sapiens (human) lncRNA induced by TGF-beta and antagonizes TGF-beta signaling 1 (LITATS1) URS000075ABAD_9606

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LITATS1: LITATS1 is a long non-coding RNA (lncRNA) that is induced by TGF-β stimulation and promotes TβRI-SMUR2 interaction as a scaffold [PMC10183827]. Ectopic expression of LITATS1 enhances SMURF2-induced TβRI polyubiquitination, and this effect is diminished by SMURF2 depletion [PMC10183827]. Higher expression of LITATS1 is associated with a favorable survival outcome in breast and non-small cell lung cancer patients, suggesting its potential as a predictive biomarker for cancer progression [PMC10183827]. LITATS1 ectopic expression suppresses TGF-β-induced cell migration in MDA-MB-231 and A549 cells, as well as cell extravasation in a zebrafish embryo breast cancer xenograft model [PMC10183827]. Conversely, depletion of LITATS1 in MDA-MB-231 cells enhances TGF-β-induced cell migration [PMC10183827]. These findings highlight the functional role of LITATS1 in modulating TGF-β signaling and its potential as a therapeutic target for cancer treatment.

Genome locations

Gene Ontology annotations

Sequence

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CUCCGCUCCUCGCGUCGCGGCCCCGCCCCCGCGGCCGCUGCGCGCCGGACGGGGCCCAAGCGGGGGUCGGAGCCUCAAGGCUGCGGCGGCGACGAGCUCCGAGCGGGACACUGAACGGCCCGUAUGCGCAAGAUAAGCACGGACUGAAUCAGGUACACGCACCUGCCGGGGACGCACUGACCGAGGUGCGGACGGCGGUACCAGGACAGGUAAAGCCGCGAACACUCGGACCUAAGAACUUGACAGGUACACCCUGCCUGAUGAAGCUACGUACGGCCAGGUGCGCAUCGAGUGAAUCAGAGACGAAGUUUCGCCAUGUUGCCCAGGCUGAUCUCAAGCUCUUGGGCUCAAGCAAUCCACCUGCCUUGGCCUCCCGAAGUGCUGGGAUUACAGGGUGAGAACCUACUUCUUCAUAAAGAGAAUUUGGAGGGAGCUUUUUGUUCUGCGGGGACAACAUCUGGAUUUGAAUACAUCCAUGCUCAAAAGGAGAUUUCUCAUAAUGGACCCAACUGAAAGCACUCAGAGUACAAGGACCGGUGAGCUUUCAAAAGGAGACACUUCGGGAGACUCGCCAGGGGCCCUCGUAUCCCCGGCAGCGCGAGUUUUGGAGGUCAGUGGAGGGCUCUCGCAUCAUGCAUGUAACUUUCAUACUCAAAAACUUACCUUCAUCCUGCAUCCCUCACCCCCCUGCAGAAACUUGGGGCUUGAAUUCAUUUAAAAACAUUUGCGGUUUCAGAAGCCUUCUUUUUAUUAUGAAGCUGCCAAGGAGAUCUUAGAAUGAAAGGCAUUUUUAGAGAUGAGAAAGAAGGAAGCCAGGCCAAGGCUGGGCCGGCUCUCAGCCGUGGGUCUGUAAAGGUGACACGUGGGACAUGGCCACCUGCAGACCCUGCAGGCGGCUGGGCAGAGGCACCCACAGGGACCUGGGUUUGAAUCCCUGCUCUGCCAGUCAUUUCCACAGCGAUCUUGGGGGAAGUUGUGUAACCUCUGGGCCCUGCGACGCCCUUUCCUGGAGCCUGGAGCUGGAACGAAGCCCCUUGGAGCCCUGACAUCAGAGGUGACGUUAGUCUUCGCAGGCAAUGACUCGGCGGAAUGUGAUGCCACUCCCUAACCCGUGUCCGGACUGGCAGAGUGUGUGCCGCCUCCCACCAGGUGGUCUGGCUGCUUUGAUGGAUCUCCUAACUUCUCUGCACCCCAGAGCCCUCAGUGCUGGCCAGACCUUCACUCACUCCUGGGUGACAACCCCGUUCUCAGAUAGUGGGUCCCACAGGCUGGCCUGUGGCGCCCCCUGCUGGUGACUGCAGGGAGAAGGAUGCCCUAAGCCAAAGGAAGUCCUUCCUGGGGUCUAAUCUCUACCUUUUGCAUGAUGAGGCAGCUGAGGUGGCUCGCUUUCUCCUCCACCCCAGAAAAUAAAGUCAUAUGGAGUCCAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications