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Homo sapiens (human) long intergenic non-protein coding RNA 548 (LINC00548) URS000075AA30_9606

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LINC00548: LINC00548 is a long non-coding RNA (lncRNA) that has been studied as a potential off-target site for AAVS1 gene editing. Mussolino et al (2014) identified LINC00548 as one of the off-target sites using the bioinformatic tool PROGNOS [PMC5666315]. In their study, Mussolino et al (2014) experimentally validated LINC00548 as an off-target site, along with ATRNL1, BEGAIN, CHRAC1, and H19 [PMC5666315]. The off-target sites BEGAIN and LINC00548 were found to be located within introns, while H19 was located in an intergenic region [PMC5666315]. Deep sequencing analysis showed low off-target activity for LINC00548, H19, and BEGAIN (0.52%, 0.17%, and 0.02% respectively), while no off-target activity was observed for ATRNL1 and CHRAC1 [PMC5666315]. Additionally, the expression pattern of LINC00548 was assessed using qRT-PCR in independent samples [PMC5797088]. The study found that LINC00548 showed lower expression levels in CColder samples compared to CCyounger samples [PMC5797088]. Overall, these findings suggest that LINC00548 is a potential off-target site for gene editing with low activity and may be involved in the CC-oocyte dialogue and oocyte quality regulation [PMC5666315] [PMC5797088].

Genome locations

Gene Ontology annotations

Sequence

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AAACAGUUGCUGUGGGGAUUGAAUGACUAGUGCAUGUGAAGCUGCCAGUGUGGUGCCUGCCUCGGGGUUCAUCAAAAACAGGAAGUCAAAGGUCUGAAUACUCUUCCUGUGAAUCAACAGAGAAAGCUUUCUCAUCUGAGCCCAUGAAUACGCAGCCUAGGGCCACUGACUUGUAAGAAUGGAGAGUUGCAAGCUGGACCCUGGGGUAUCAGACAGGCAGAAUCCCUUGCAGCUAGAGUCAUGGAAGCGAAGAAGUUUCCACAAUUAGAUGUGCCUAUGCAAGAUUUGAAAAGAGGAAAUGUGACAAAAGGGCAGAGUUCUGCAGCUUUGACUACUUUUGCUGGCAUGCAAGGUCUUGAAGAUGCUGUGCUUUCCUGCAGCCAAAUUCUACUGUAUAGCCACAAGCUUCAUGAAAACCUUUGGAGUCAUUUUCUUUGGAGCGGGAGUUGGGAUGGUUUGCUGCAGACACCCAGAUGUUUGAUGCUAUGUCCUUUUAUCUUCACCUGCAUGAGGCCGCUUGAUAUUGAUCUCACUGCAGUCCUCACUACAUAGCUCAUUGGAGUCCACACCAUGGCUUCGUACGAGUGUGCACAUGCAGUCAAAGGCACCCUUAAUGCCUGCUGCUCUGCGUCCUUCGAUGUCUCCUGCUCAGCAGUCCAGCUAUUACAAGAGGCACAGAGCUGAGCAUAUUGCUUCAGACCCAGAAGAAUCUCCUCCAUCCCAAUUGGGUACAAUUGUGAAGGAAAUGUGUUGGAGGAAGUCACCUUCUGUGAGCUGCUUAUCCAUCAAGUUGCACUCUGUGUGGGUGUGUAUCCUUCCUAUCUUGGCUGUCUUAGGUCUCCAUAUCCUAGGCAGUAGCCGGGUCAGUAUUCCUUACCAUGCACAUUUGGGCAAUAGAGGUACUGGACAAUAUAGGUAAAUUCACAACCAAUUCUUUCCCUGCAUUUUCUCCAAAUCUGUGGACCAAAUCCUACUUACCCAUGGCCCUACAAAGUUGUCUUUCCUAUCAACACUAACACACCACACCUUGUUUCUCCUAACCUUCCCAGAAUUCCUUGAAGGCUUUCUGAUAUUUGAGGCUUGACAAAAUUUAUUCAUGCAUUGAUUAAGCAGCUAGGAUUUAUUAACCACUGUGAAACAGAAAUUUUGCCAGGCAAUGAAGAUAUUUAGUUGAGUAAGACAGUGCUUCUGUAUUCAAGAAGUCUACCUGUGACCUAUUUUAACUGUAUGUUUCCCUGAAUUUGGGGCAUUCGAAUGGUAUGUACUAAAUGUCUUAUUGGAUGGUUCAUCCUGGAGGAGCGGCUAAUGGAGGCUGGAGUCAAGCUAGGUGUCUGGGCUCAUGUCUACCUUCUUCUGAGUAUCAGAGGGCAGACUCUGAUGUUCUCAGAGAUAGAUGUUCUCAUAGUCUUCGGCUGGAGGAAAUGCCCUUGUUCAUGCCAUCUGUUGACCUGUAGCUACCAUGUAGACCUCUCUGAGGGCCUGUGGCUCAUCAGGAGAUCCGAUGGACACCUGAAUCUCAGAAAAACUGACCUAUGGCACUGUUGUGAUGCACAGGUAUAGGCACAUCUCAAAACAUACCCGUAAAUGUCCCAAGUUUGAAUAUUUUCAAAAUUAUAAGCUUGUAUAUAGCUUAUAUAUUUGCAUUGUAAUCCAUUUGUACAGUACCUAAUUCAAUGCGAGCAAUUACUAAUUUGGAAAUUGUACUGAUAUAAAUAAUUCCUCUCUUUAUUGCAUGUAACACUGUGUCAGUGAUAUAAAAGCUAUGUGUGUAUAUAUAUACAUAUAUAUAAUAUACAGAUGUAUUGAAAUAACUUUUCUAUUUGUAAACAUAAUGGAAUUACUGUAGAAUAUCACCCUCAAGGGAAGGAAGAAAUACAUGUGAGCACUUUCAGGGUAGUUUGCCUGCAUCUGAGCAGUUGUAGAUACUUUGGUGGUAUAACUGGUGAUGAAGAAGAAGGAGGGAAGUUGCAGAGGAAAGAAGCUUGGAGAUGUUUGGGAUAGCUUUUUUAAUUUUCACUGGAGUCGAUUGUGCUAGGGCUUGGUUUUGAGGAUCUGUGGGUAAAUGCUGAGAGGGGUGGGUGCAGUUGCCUAGGCACAAAUAUCUGAAUAGAGCAGAUAUGGAUGAGUGGUUCAGGGGAGGAAAUAUUAUCUGCCUUCUUUUCAUUCUGCUUCAUGCUAGGCAGGGCAAUGAUGAUUGGUUUUCAUUCAGCUUGUGCUCCAAGAGUACCUCAGAAAAUGGGGAGCCAUUUUUCCCCAGUUUUGGUUUUUAGAGGUUUAUAUCCCCAACUGGCUAUGGUUGGCUGGCAGCCUUUAGCUUCAGUGUAGCCACACAUGAUUUCACGUCGUCUGUACAUUCUUCGGCAGGAACCUGCUCCUUUUACUUCCAGUGGACACAGAGCACUUCAGCUAUGGGCAUCCAUAACUACUUCCUCCUGGAUCUGAGGCUUUCUUGGCUCUGAGAGCUUCCUGGGUUUGCUGACCUCACCCCUGUGAGGAGGAGGAUUGGCCCGGCUGCUGAAAACAUACGUGUAAUUGAAGGAAUUCUAUUAAG

Taxonomic tree

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Publications