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Homo sapiens (human) long intergenic non-protein coding RNA 1139 (LINC01139) URS000075A909_9606

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LINC01139: LINC01139, also known as LINK-A, is a long intergenic non-coding RNA (lincRNA) that is upregulated in various diseases, including breast cancer, ovarian cancer, liver cancer, and osteoarthritis [PMC9964205]. It has been shown to interact with phosphatidylinositol 3,4,5-trisphosphate (PIP3) and Protein Kinase B (PKB/AKT) in breast cancer cells [PMC5828204]. In ovarian cancer, LINC01139 has been identified as an independent risk factor for recurrence [PMC7934452]. It has also been implicated in drug resistance to AKT inhibitors and increased tumorigenesis in breast cancer cells [PMC6724670]. LINC01139 has been shown to interact with AKT and PIP3 in triple-negative breast cancers and is associated with oncogenic function [PMC9526990]. In liver cancer, LINC01139 promotes the progression of the disease by upregulating MYBL2 via competitive binding to members of the miR-30 family [PMC8725365]. Its role in MODY3 diabetes is still unclear and requires further investigation [PMC8290520]. LINC01139 has also been associated with immune escape by causing abnormal expression of proteins in the antigen presentation system and is linked to immune-related diseases like psoriasis [PMC9270757] [PMC8053058].

Genome locations

Gene Ontology annotations

Sequence

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UGGAAUUCAAGCUGUGGGUGAGAAGCUCUCUAGCAGGGACUCUGACCUUAUGGAGGAUCGCUGUUUCCCCCAUUUUUCCUUUUCACCCAAAAAAGUCCUGCUUCUCUCACCCUUCAAACAGCCUGUGAGCCUAAAUUUUUGUGGCCAUGGGACAGACAAGGACCCCGUCUUCAGCUGAACUAAGGAAAAGUCCUGCGACAUCUUUGGUACGCACUGUGGAGGCUCUACAAACAGCCAUCAAACUCCAACCAGUCACCCAACCAGAGCCUCUGAGGAUGGCCCCUUCUGCGGGGAACCCUUACAUGGGCCUCUGACUGAUGCUUCCCCAAAACAGUGCCCCCUGUCAUCAGGAAGCAGUUAACACUGGUCUUCAUUCUUACGCUUAUCCUUAUUCUAACAGCAGUUAUAUGUACUUCUUUAGACGGGGGAAUAAGACAGCCAGGUGGGAGGGGGUCUCUGGAAAACUCCAUCUGGCCUGUGCACUAGGGUGGAACCUCAGGAAGUUGAUGACAUUUGUAGCUGGGAGCAGCCUGGCCCCUCCUCUUCCUGUGUGGAACCUGAAAUUCCACCGGCUUGGCAGGAAGCGCUCUAGCAGGGACUCCGGCUUUGCAGAGCAUCCCUGUUUCCCCGUUUUUCCCUUUUCACCCAAUAAAACCCUGCUUCACUCACCCUUCAAACCAUCUGCAAGCCUAAAUUUUUGUGGCUGUGGGACGGACAAAGAUGCCUUUAGCUGACUGAGGAAAAGUCCUGCAACACAGGUAUCACUGCACAUUUAUAAUAUUGUUUCUCUGUUUUAAACCUUGUAUAAAUAGGAAAAUAUUGUAUAUAAUCUCAAGCAGAUUGUUUUCUUUUGAAAAGUAUUCAUAUAUGUUAAAGAUGUAGUUCUAGUUCAUUCAUUUUCUCUGUUUUGACUCUUUUAUACAUAUACUACAGCUCAUUUAUCCAUUUUCCUACUGUUGCAACAUAGAUUGCUUAUAAUUCUUCUAAUUACUAACAAUGCUGGUAUGAAAUUGUUGUGUAUAUCUCUGGUAGAUAUGUGUUAUUUCUUUUUUGCAAUGCUAGAUUAUAAUUAUUUGUCUAAGGUGGAGAUUACCAGGGUAGACUCGCUCUGGCCGUAUGUAAUGAUGUCUGUGGCUACAUAACCUGCCAACACUUAGUCUUAUCACACAUUUUAUUUUAAAAUCAAUAUGUAAAAAAUACUAAUUUACUUGGUAGUAAUUUAAAUUUUUCUGAUUAUUACUGAGGUUGAAUAUGUUUUCAUAUGUUUACUGAAUAUUCCUGUUAAUUUUCUCAUGAAUUUCAGUUAAUGUUUCUGUUGAUUUUAUUAAUUUGUAGUGGUUUUGAAACAUAUUCUAGAAACCAAUAUUUUGUCUGUUGUAUGUGUUACAAAUAUAUUUAUUUUGUAUAGCUUCUUCAUAUUUAGUACUUUUACAAUUUUAACAGUAAAAUUAGUUUCAUGUUUUAUAGCUAUAAUUAUUAUAACUUUUAAAUAAAUAUUUCCUCAAUUAAAAUAAAAAUGCAUUAUCCUUAAAAAAAAAAA

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Publications