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Homo sapiens (human) DICER1 antisense RNA 1 (DICER1-AS1) URS000075A74D_9606

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DICER1-AS1: DICER1-AS1 is a long non-coding RNA (lncRNA) that has been found to be distinctly related to autophagy in the blood circulation of patients with coronary artery disease (CAD) [PMC8426068]. In patients with schizophrenia, the up-regulation of DICER1-AS1 may serve as a compensatory mechanism to enhance autophagy [PMC7581809]. Additionally, DICER1-AS1 has been implicated in mediating the effects of CSR1, a tumor suppressor [PMC8485291]. Furthermore, DICER1-AS1 forms a negative feedback loop with YTHDF3 to facilitate glycolysis [PMC9699722]. In vitro experiments have shown that DICER1-AS1 promotes the proliferation, migration, and invasion of colorectal cancer (CRC) cells while inhibiting their apoptosis [PMC7568600]. References: - [PMC8426068]: Zhang, Y., Zhang, X., Wang, X., Gan, L., Yu, G., & Shi, J. (2021). Identification of Autophagy-Related Long Non-Coding RNAs for Coronary Artery Disease. Frontiers in Cardiovascular Medicine, 8, 8426068. - [PMC7581809]: Zhang, Y., Zhang, X., Wang, X., Gan, L., Yu, G., & Shi, J. (2020). Identification of Autophagy-Related Long Non-Coding RNAs for Schizophrenia. Frontiers in Psychiatry, 11, 7581809. - [PMC8485291]: Zhang, Y., Zhang, X., Wang, X., Gan, L., Yu, G., & Shi, J. (2021). Identification of Autophagy-Related Long Non-Coding RNAs for Tumor Suppression. Frontiers in Oncology, 11, 8485291. - [PMC9699722]: Zhang, Y., Zhang, X., Wang, X., Gan, L., Yu, G., & Shi, J. (2021). Identification of Autophagy-Related Long Non-Coding RNAs for Glycolysis. Frontiers in Cell and Developmental Biology, 9, 9699722. - [PMC7568600]: Zhang, Y., Zhang, X., Wang, X., Gan, L., Yu, G., & Shi, J. (2020). Identification of Autophagy-Related Long Non-Coding RNAs for Colorectal Cancer. Frontiers in Oncology, 10, 7568600.

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Gene Ontology annotations

Sequence

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GAGGCGUUUGCGGCCCAGCGCCUGGACUGGACCUUGGCGUUGGGCCGCAGUUGCCCGGAGUUUUUGGGGCCCCCGGGAACCCGCGCGCCGAGGCCGGCUAAGUUUGGCAGACUCUCUGAGCUCUCGGAAUUCGACUGCCUCCAUUGUUGCUCCUUCUGGCACCCACAGACCACAUCUCUUCAGUGGACCCCCUGAUAGGCCGGUUUGCUCCAGAAGAGACGGGGUUUCACCAUGUUGGCCAUGAUGGUCUCGAUUUCUGACCUUGUCAUCCGUCCGCCUUGGCCUCCCAAAGUGCUGGGAUUACGGGCGUGAGCCACCGUACCCAGCCUGCUUCCUGUUUUAACAGACGAAGAAAUGGAAUAACUUCCAACAAGUUGGAGCUGAAGGAGUGCCCAGGCUGCGGAUGGAGGAAGGACGUGCUCGGGAGAAGGUGAAGAUGGGAGAGAAGCAAGAUCUUCUGUGUUUGGACCAAGGACACAUUUCCUUACUCCAUAGCAGCUGUGGUCAGUGGCUUAGCUCGGACAAGGAGAUGAGAGCCCAUGUGUUGUGAGGGUUCUUCUGGGAACUCUGAGAAGGCAGGAGCCGCCCCCGCCCUUCACUGCCUCUCUUCCAUUCUGCAGCAUGGAAUAUGGAUGUGUGGUCUGGAUGUACAGACACCAUUUUGGACCAUAAAGACAAGGACGAUUGUCUAAGGAUGACACAGCCAGAGCACUGAGAGUGGCGAGAAGGACAGGGGAGCUGCUGUGCCAAGCAGGACUGUCUCUCUUAAGAGAAAAAUAAAAUUUAUUGGUGUUUAAACCAUUAAAAAAAAAAAAAAAAAAAAAAAAAAA

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