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Homo sapiens (human) LGALS8 antisense RNA 1 (LGALS8-AS1) URS000075A2FE_9606

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LGALS8-AS1: Kaplan-Meier analysis demonstrated that higher expression of LGALS8-AS1 was associated with significantly poorer survival in breast cancer patients [PMC8570098]. Functional assays revealed that overexpression of LGALS8-AS1 increased the metastatic ability of breast cancer cells, while silencing LGALS8-AS1 inhibited metastasis [PMC8570098]. Additionally, a positive correlation was observed between the expression levels of LGALS8-AS1 and SOX12, a transcription factor involved in cancer progression [PMC8570098]. It was also found that LGALS8-AS1 could be transcriptionally activated by SOX12, suggesting a feedback loop mechanism [PMC8570098]. Furthermore, miR-125b-5p was identified as a potential regulator of LGALS8-AS1, and its overexpression or knockdown could reverse the effects of LGALS8-AS1 on metastasis [PMC8570098]. The study also highlighted the involvement of the AKT signaling pathway in mediating the effects of LGALS8-AS1 on breast cancer progression [PMC8570098]. Overall, this study provides insights into the molecular regulatory mechanism of LGALS8-AS1 in breast cancer and suggests its potential as a prognostic indicator and therapeutic target for breast cancer patients [PMC8570098].

Genome locations

Gene Ontology annotations

Sequence

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AGGGAACGCAAUGGAGGUCACUCCACUGUCACUACAAAUUCCGGGAAGGAAACUUCCCCAGAUUCCUCCACUUGGAGGUGGCGCUCGGCCUCAGGCUAGGAGGGAACAGGUGAGAAAGCAGCCCAGGUGGGGUGGGUUUGCAGCGAGGAGACACCCCAGGGCAAACAGCCUGACCCCAGCCAGGGAUGUCCAAGAAAGGCCGCGACUCCUGAUAAUCCCUUAUGCCCCGGAGCGCCUCGCCUGCAGAGGCAGCGUCCCCGCCACCCAGCCCCGGCUCUGCCGCGGUGAGGACCGGCGGGUCGGGGUGGACUGGACACUGUCCCACCCAUCAAAUGGUGAUUUAGGAGCCGUGACAUCCGAAUGCCAUCCUCCACUGGCGAGACCCUCAGAGCAGCCACGCCUCUAGCGACUGCCCCGCCACCCGAGGCCGGGGGUCGCGCGACUCACCCAAAGACUGGUGUUUCAGGCGCUCCACGGAGCAGGUUGUUUGUCAGCAGCUAAGUGCCGUCAGGGUUCCCGGCUCUGGCGUCCGUGGGCGGCUACGGGAAGCGACAGGAGUCAGUCCUCGUUCACUUCCCGGCUCGCGCGCCUCACUGCUGUGGUCUCCCCACCCUCCCCGCGCCCCGCCUUCUGUGUCUGGGGCGUCCCUGGCGGCUCUGCUGGGUUUUGGACAGGGACCCGCCGCUGAUCGCCACCCAGCUCGGCCUCCUGCACAGCCUCUGGAGCCUUGGACCGCGACUGGCUUGCUGUGGGACGAGCACAGAGGGAUAAGGACAAAGAAUGUGUCCUGGGUGGAUCUGGCUGCCUUUGCCCGGAAGGCGGAGUGGGGUGGGAGGUGGUAGGAAAAUGGGAAGGAAAGAAAAGAAAGGUGGGCCGACGUCCACCUGGCUGUUCCAGGCCUCCAGGUCUAGGAGGGAGGGCGCUCGGGGCUGGGACUUUUCAGGACCAGGGUGGUCACCGCACAGGCCCCGCCUGCCUGGACCAAGCGCUGGCCUUCCCGGGGCGCCCAGGUCCACGGGGUCAACGCCAGGGUUUUCUCAGCUUCCUCGUCUGCCUCGGAUCCAAGUCCAGACAGUGCCAGAAGAGACUUGGAGGCGCUGCUUUUUGACAGUACACACCUCUGUAUGCAGGUGAAACGGUGGGGGAAGGGUUCAGUACGCUGGACUGUGCCCAGCCCAAGCUCCCCAUCCGUUAGUGAUAACUUGGACUCGCAGCCACUCCGCGUCACUCGCCAGUUAUCCUGCGUGUGGGUGUUUUCUCCAAAUUGGACACUUAGGGAACAGUUUAAGCAGUAUGGAGCACAAUUCUGUGCCUAUUAGAUGCUCUUAAAUACCCGACUUCUCAGGGCCCUACACUGACUGAUAGUUUGACCUAUUGGCUGUAAACACACCAGCCAGAAAUACAAAUAAAGUUAAACAAAGUCAUGUCAGCCACUUGGAAAAAAAAAAAAAAAAAAAAA

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Publications