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Homo sapiens (human) negative regulator of antiviral response (NRAV) URS000075A220_9606

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NRAV: NRAV is a down-regulated long non-coding RNA (lncRNA) that is highly expressed in hepatocellular carcinoma (HCC) tissues and is associated with prognosis [PMC9489786]. It has been shown to promote virus replication in human epithelial cells infected with influenza A virus by negatively regulating the transcription of interferon-stimulated genes [PMC7417515]. NRAV is mainly located in the cytoplasm and has been found to influence the expression of Rab5c, suggesting that Rab5c may be a target molecule of NRAV in respiratory epithelial cells [PMC7199404]. In pancreatic ductal adenocarcinoma (PDAC), NRAV was mainly found in the cytoplasm, and overexpression of NRAV and Rab5cQ80L increased respiratory syncytial virus (RSV) gene levels [PMC9516670] [PMC7199404]. RNA pull-down experiments have been performed to identify the functional protein partners of NRAV [PMC7104942]. The over-expression of NRAV in HCC tumors has been studied, and its potential mechanisms are being explored [PMC9624069]. Sapitinib, a drug, has been found to be highly correlated with NRAV expression and can induce apoptosis and suppress phospho-EGFR and its downstream pathways [PMC10046959]. The downregulation of NRAV by viral infection is controlled by specific pathways activated upon sensing viral infection, although the exact mechanism remains unknown [PMC7104942] [PMC8420315]. It has been shown that NRAV can suppress the initial transcription of interferon-stimulated genes through affecting histone modification of these genes [PMC8569443]. The interaction between ZONAB and NRAV in regulating interferon-stimulated gene expression requires further investigation [PMC7104942]. References: - PMC9489786 - PMC7417515 - PMC7199404 - PMC9516670 - PMC7104942 - PMC9624069 - PMC10046959 - PMC8420315 - PMC8569443

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Gene Ontology annotations

Sequence

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GCAGACCACAAUGCACCGCUCACGGCGUCGGUUGCCCGGGCAAUGGGCCGCACGCUACGAGGCCCACACACCCAGAAGGUGGAGCCCCGGCCGGGUUACGAGGACCACCCAGCUGUCUGGAGAGAUGAAGAAAAUGAGGUUCAAAGAGAUGAAGUCUCUUGCCUAAAGUCAGUGACAGAAAGUGACAGAGCUGGGAUGUGAAUCCUGGUCUGACUCUACAGUCCCACAUGGUAGAUGGAACCUCCGAGCAACACCUAAACAAAAGGAGUUGAUGCCUCCGAACAGAGUAAUGUCGCUGGAGACACUAAGCAUCGUCGGCCCCUGGCAGGAGCUCCCUAAAUAUGUGUUGGAUGGAUGGAAGAAAGGAUGGAUAGUUCAGAGUACUUCAGCCUUGAUUCCUCCGCAACAGACACCUGAAACUUGACCCUACAUUGGUUCUUGGCCAUCGUGAUCUUCCUUGGACAGAAUCACCUUUCAGCUCCGGUCAUCAGACUUUCCCAGGGCCCUCAGAAAGCCCUUCAGAGUUGUUACUCACAGGCAGGCUGAGGGAUUCCUUACGGGGUCUGCAGCUCUCCUCACCUCAUCCACAAGUAGGACCGUGGCCUGUUCCUCACUACUGCCCCAGGAUCACUCUGUUCCCAGCCCAGUCCAGCAAUCACUUGUCUAGCUUUCUGGAACCUUGAGUACUUUCUUGAACCAUGAGUCCUGUGACCACCCUAGCAGCUCUAACCCUCCCUUAUCUGAAAGGAAGUGUGAGGUGACCUUGCAGGUCCCAGAGUUGAUUGAAGACCCCAUCCAGAAAGAAGGCACCCUGUGGGAGAGAUUGCAAGGCCUAGGUCUGAAUCCGGAAGCUUCCACCCCAUGGAGAAGGGCUGGCACCAGCCUGGGGCUGGCAGUGGAGCUGAGCUUUGGAGCCAAGGACUGUACUGCAGUGCAGGGAGAGUGAGGCCAGAAAGGCUGAGACAACUCAGGGAAAGAAAACCUCCCUUCUGGCUAAUAGUCAAGCACCGCCUGAGUAGACCAACACUCUCCUGUCCACAGGGGCAGCAGAUGAAGACACAACCAGAGAGGACUAACAGGCCCCCUCAGCUCUCAGUCAGAGGGCAGAGCAACACAGAAUAGACAUUAAAGGAACAGACUUUGAGGCCAGGCAGCCUUGGGUGUGCAUCUGUCCCUACUAAGCCAUGUGACAUUAAACAAGUGAGUCCACCUCUCUGAGCCUCAGGUUCCUCAUCUGUAAAAUGGGGAUUAUAAGAGUUCUUGUUUCUCAGGGACAAUGUGAGGAUUAAGUGAGAUGAUACACAUAGAGAAUGUGGUGCAGUACUGGGCACAUGGCAAAGAUCAGUGAUGCUAGCUACCACUUAUCAUUAGUGUUCCUGUAGACCAGGACUUCUCAACCUUGGCACUAUUCACCUUUUGGGCCAGAAAGUUUUUUUUGUUGUUGUUGUGGGGAGCUGUCCUAUGCAUUUGAGGAUGUUUAACAGCACCCCUGGCCUCUACCCACUAGAUGCCAAUCACACCACACCCCCAGUUUCAACAACCAAAAAUGUCUGCAGAUGGUGCCGAAUGUCUUCUGGAGGGUGAAAUCACUCCCCAGCAGUUGAAAAGCACCACCCUAAACAAUCUGGACUGAAUUUGAAUGUCACAGAUCCCAAGCUCACAGCUCCAUGUAAAGGCCACAAGGCAGGCAGGCCUACUUGCAGAUGAAGGAACGGAAAGAGCAACAAUUACAGAUCAAGCGGCUAGCUCCGGUGUAGACUAAGAGGCGGGAUCUGUAGUCUGCUCUAGGAGCUAACAAGGCCUCUGUGACUCAGUAGGUGACCUCAGUGUCACUCUUUAAUUAUAUGCAAAGUGGUCUUGUGUUAACUCUUAAUUAUUCUAGGGCUCCAAACAAGAA

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