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Homo sapiens (human) ITGB2 antisense RNA 1 (ITGB2-AS1) URS000075A18C_9606

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ITGB2-AS1: ITGB2-AS1 is a long non-coding RNA (lncRNA) that has been implicated as an essential oncogene in acute myeloid leukemia (AML) and is likely involved in the pathogenesis of AML through its role in the immunosuppressive tumor microenvironment (TME) [PMC8266366]. In a study, the expression of EGFR was found to be significantly decreased in the siRNA-ITGB2-AS1 group compared to the siRNA-NC group, while it was significantly increased in the ITGB2-AS1 group compared to the Vector group [PMC9987676]. This suggests that ITGB2-AS1 may regulate EGFR expression [PMC9987676]. Furthermore, analysis of the ITGB2-AS1 sequence paired with ITGB2 gene using UCSC genome browser revealed a complementary base pairing of 231 bases between them [PMC6073814]. In conclusion, ITGB2-AS1 is an oncogene that plays a role in AML and its pathogenesis through involvement in the immunosuppressive TME. It may also regulate EGFR expression. The complementary base pairing between ITGB2-AS1 and ITGB2 gene suggests a potential functional relationship between them. These findings provide insights into the molecular mechanisms underlying AML and highlight potential therapeutic targets for this disease.

Genome locations

Gene Ontology annotations

Sequence

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UGUCAGAGAGCGGCCCCUUGAGACAGGUGGGACAUGUCAUUUCUCACAUGAGGUCCCGGCGAGAAGGACCUGCUUCCAUCAGAUUCACACUUGGGAGAGGGGCCCGGCCUCCAGGAGCGCCAGGCAGAAAGGGCACCCAUUAGGAAGAAGAACACAGAGGCCAUGGGAGUGAAAAGUUUGAUGCUGGAAAGCAACAGUAGCACAUUCUGCUACAGAGCGGAAUGAAAAACCCUGGGGAGCAAAUUCCUGAGCCAGAGAAUGGAGCGGAGGAACCAGCCAAGGAGGAUAAAGAGGUGGGAACAGGCAAGAAAACCUGGACUUAGCCUAGAAAAUAAUGAAGAAGGACAGAAAGAGAAUACCAUUCUACUACACCCGCUGAUGACUUAAAACCUGCGUGCUCUGAGGCUGCCCGACCCUGAGCUCCAGAACAGACCAUCGAGUUCAGGAGACAAGCAUGUCAGCCAUGACACAAGGCAGAUGAGAGGGACCCCCAGCGUCCACACGUGGAGGCAGCGGGGGCAGCCGUGACUUCCUUCUGCAGUGUUGAUUCAGCUCCCUUUGAAGGCGGAUCCAUACAAACAGGCUGACCAUCAGGGCUGGUCCCAGGCCACCAGGCUGGGUGCAAUGCAGAAAUGGAGAUCUGCCCCGGGGAAGGCAGGUGAGUGUAGGAAGGAGGGAGGGCUGCGAGAAGCUGGGGGCAGCCUCCAUCCCCCUGUGGCCUGGGUGGGCCUGUGCCCCCCCAACCCCCCGACGCAGCUUCCCACACUGGGAGCACAGUUCCUCCCUCCUCUGCCUUCCUCUGCGUGGUGUGGCUCCUCCUUGAGGGAGAGAGCUGAGGAGGUGGCAUUCUUGCUUCCCUGACUCACCCAAAGGAAGAUUUCACAGCCCCUGGCAAGGGCUGCCAGACAGGCUCACCUGUCACCCCCUGUCCAGGGACAGACUGACCGGUAGCCUUGGCUGGGUGGGGAGUUAUGCUGGGAAGUCUUCCAGGCCCCCUGGGGGUGGGAAGAUGCUCAAUGUUCAAAGGAGAUGGAACGAGGAAAACAGUUAAGCAACGAUGGACUCCAGGGGGAAAACCGGAGAAGAAGAAACUGUAAUUCCAGUCCGUCCACAUGGCCCAGCAGUGAACGACAAUUGCAUGGUCAGAGAGAGCAAAAGCACCACGCCGACUGAAAGCAGCUCGAAUGUGGUGGGGCAGUGGGAGAUAAUGCCCUCAUCUACCAAAACAAGAUCUGCCACCUUCGCAGACCACUAAACCUCAUUCCUCCACCCACCUCCCCACCCCCAUGAAGGCCAACUGACCAGAGAGCAGGGCUCCCGAGGGUCGGGUCGGGUCGGGUCGGGUUGGGUCGGGUGGGUGCCUCUUACCCUAACUGAGGCUCUGCCCUGGACUCGGAGUCCACUUGCUGUCAAAGCAUGCCACUCUUCUUUCUGAUACUUGACAUAUUUCUUUUCCCGUUCAAUUCAUGGUUUCUGCCCAAACGGAGCCACGUGAGGACUUCUUUGGGGAUGUGUCUCCAAGAAAAGUGUGGGCUGCCUUCCUCACCCUGGAUGCCUGUGGGCAGCCUUCCUCACCCUGGAUGCCUGUGGGCAGCCUUCCUCACCCUGGAUGCCUGUGGGCUGCCUUCCUCACCCUGGAUGCCUGUGGGCAGCCUUCCUCACCCUGGAUGCCUGUGGGCUGCCUUCCUCACCCUGGAUGCCUGUGGGCAGCCUUCCUCACCCUGGAUGCCUGUGGGCAGCCUUCCUCACCCUGGAUGCCUGUGACUUGGUUUCCAUGGGGGCUUCCUAAGCUCAGGGACCCCAAGCCUCCAUCAAAUCUAAUGACCCGCCUUGUCUCUGAACACACCUGUGUUGUCCCCGAGCCCCUCACCAACCCCCUCUGCAACCCGGCCCACGCAUUUCCCAUCCUGAAGGGUCCAGCUCAUAGGCCGGCCCAUGUGUUCCCUUUACCCCUGCUUUGUCCCUACCUGGUGGGGAGCUGUCCCUUCUGGGCCCUAGUGUGGCACUUCACACACAAAUGUGUCCUGUGGGUGGUAUCUGGGCCUCCCCCUGCAGUGAGGGGAUGACCAAUGUGCAGAGCUCACUGGGCCUGGAUAUGGGCUCGGGUGGCACAGAACAGAGAGAAAGUGCUCCGUAAAAGUGAGCUGCGAUGCGGAGGUGGGCAAGCUCUUCCCUGGAGGGGGAAGAGCUCUCAACCCAGAGGGAUCUGACCAGGAAGGUUCACCCCCCCUCCACCCAGGAAGCCCCUGCAGACAGUAUGUGUUUUAGGCUUUGCUGGCCAAAUGGUCUCUGCCGCGACUACUCAGCUCUGCCAUUGUGGCUGCAGAGUGACCAUAGACCUUCUGAAAGUGAAUGAGUAUGACUGUGUUCCAAUAAAACUUUAUUGACAAAAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications