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Homo sapiens (human) GRM7 antisense RNA 3 (GRM7-AS3) URS000075A0C6_9606

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GRM7-AS3: GRM7-AS3 is a long non-coding RNA (lncRNA) that interacts with miR-936 and is testis-specific [PMC8231607]. Along with ARHGAP26-AS1, BSN-AS1, and KRBOX1-AS1, it has been found to interact with miR-936 [PMC8231607]. GRM7-AS3 and KRBOX1-AS1 are more well-known and studied in the literature [PMC8231607]. However, there are currently no studies that have reported an association between GRM7-AS3, COVID-19, and the male reproductive system [PMC8231607]. GRM7-AS3 is complementary to a functional RNA called GRM7 [PMC8231607]. It has been found that the expression levels of GRM7-AS3 and other testis-specific lncRNAs are specific to testis tissue, suggesting their potential crucial role in the male reproductive system [PMC8231607]. In addition to its role in male infertility after SARS-CoV-2 infection, GRM7-AS3 has also been implicated in cancer. However, little is known about its regulatory role in cancer [PMC6915924]. Low expression of GRM7-AS3 has been associated with a high overall survival rate in patients with Wilms tumor (WT) [PMC6915924]. In conclusion, GRM7-AF3 is a testis-specific lncRNA that interacts with miR936. It may have potential diagnostic applications in male infertility after SARS-CoV2 infection. Additionally it may play a role in cancer development. However more research is needed to fully understand its functions and mechanisms of action.

Genome locations

Gene Ontology annotations

Sequence

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GGUUCUACUGACUGAAGUGAUCCUAUCUUGUGACUCAUGCAUGGCACGUCUAUAAGUCAAGCUGGAAUCCUCUAAAAUAAGUCACAUGGGAAAAAAUUCUGAUCUUAUUCUAGACGAAGAAUGAAAAGCCAGGAAGCUACAUAACCCAAGGGUCCCCAGUUUGAAAUGUCUUGUUACUGCUGACAAGACCUGCAUGACUGACCAUUUGCUCCCUAAGAGAUGAAAACUGACAUUGCUUUGAAGUUCAAAAUGACAUUGCCAAAACAAGAAGAAAUGGAAAAUAACUGCAGCACGUUUAUGACAUUCGUUUCUUUCUCCACAUGAAACAUACAAUGAGAACACUUUAUAGAUGAAUUGUGUCUUCGAUUGAAUAGAGAAUGGUGGACUAGCUUUGGUUUUAUGGAAUUGGAUAAUUUGUCAUAGUUUCUGUCCCUGGAAAAAUGAGAACCCAAAGGAAAACAAGUGGAAAGCCUUUAAAAAAUAAAAAAAAAAAAAAA

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Publications