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Homo sapiens (human) THAP7 antisense RNA 1 (THAP7-AS1) URS000075A05E_9606

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THAP7-AS1: THAP7-AS1 is an antisense transcript of the THAP7 gene that has a significant impact on gene expression [PMC8949130]. It has been reported that THAP7-AS1 is post-transcriptionally stabilized by m6A modification, promoting cancer progression in gastric cancer (GC) [PMC9293946]. SP1, a transcription factor, activates THAP7-AS1 and supports its role in facilitating lymphatic metastasis [PMC9776883]. METTL3-mediated m6A modification enhances the activation of THAP7-AS1 by SP1 [PMC9776883]. In GC cells, THAP7-AS1 is upregulated compared to normal gastric cells [PMC9776883]. In contrast, decreased expression of THAP7-AS1 is associated with worse survival time in cholangiocarcinoma (CCA) patients [PMC9519560]. The decreased expression of THAP7-AS1 also affects the expression of MBNL3 and RCN2 in CCA patients [PMC9519560]. Additionally, down-regulated THAP7-AS1 promotes the expression of hsa-mir-155-5p and inhibits the expression of MBNL3 and RCN2 in CCA patients [PMC9519560]. LINC00519 and THAP7-AS1 have been identified as potential drug targets and biomarkers for CCA, with involvement in key networks explaining CCA occurrence and progression [PMC9519560]. The m6A modification by METTL3 enhances the expression of THAP7-AS1 in GC cells and is associated with positive lymph node metastases and poor prognosis in GC patients [PMC8966750][PMC9745091][PMC10111779][PM91081667][PM9617388][PM9097454][PM10111190].

Genome locations

Gene Ontology annotations

Sequence

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GGCGGGAGUUAAGUCGCAAGCGGCUCUCCGGGCAUCCGGAGGAGCCUCGCGCCUCCAGCCGCCGCUCCUCCCCAAGGGGCUCUGGCCUGUCGGGUCCCCCCCGGCCCGUUGUCGCCCCAACCCCGUCCCAGCCGAUUCUCUUGACUUCUGUCAGCGGCACUCACGCUCUGGCCAUUGCUGCGCCGCCGAAGUCUCGCGAGGGGUAGCGCGCGCCGGAAGUUGGUACCAUAGAGACUGGAGAGCCGGAGGUGCCCCCGCCACCGGGGCGGGGCGGGGCGAGGUCCUAGCUAGCUGGGUUAGUAAGCGGCGCGAGCGUGCGAGUUUCUGACGCGCCCGCGUCGUCCCAGCUCCCUGGACUACCAGUAUUGUCGCCCACGUGGGCUUCUCUUUCGUCCGCUCAGGCCUCACUUUUCUCCGUAAACACCCCGGCACGAUGGAGCGGCCCCAGCGUUCGGGAGCGGCCCGGGAGCGGAAAGCGGCAGUGUCCUGGGAGCCUCGAAAGCCGCAGGGGCGGCAGCUCGCCUCGGAAUGACCUCUGACGGAAGAAAUAAAACGGGGCCUGGGACGCUUGCACGAAAGAACCCGACAAAAACCAGAGCCCGCACUCACUCUCGUACUGGGGAGGUGGACUUCAGGGAGGGUUAUCUGGAGGAGGAAUCUCUCAAAGUACAACACAGGAGAAAGACAGUAUCGCAAUACAGAAAUUUUAUUUUUUAUUUUAUUAUUAUUUUCCUGAGACCGGAGUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCGCGAUCUCGGCUCACUGCAAACUCCGCCUCCCGGGUUCACGCCAUUCGGCUGCCUCACCCUCCACAGUAGCUGGGACUACAAGCGCCCGCCACCACGCCCGGCUAAUUUGCAAUACGGAAAUUUUAAUAGCUGACGUGAAAAGGGGUUGUCUCCAUAAAGGAUGCGGGCCUUCAGGGGCAGCAUUAUUCUGCAGGUCUCCUGCUUCCUGAUGGCACAAGGACUCCACAUCACCCAGUCCUACCUUAAAUCCAAUCGGACACCAGUCCACAAACUGGUUGGUGUGCUUGCUCUUGAUGGUGGCGACAGCCGCACUGACAUCUUUCAGGACCACAUCCCCUCUGUACAACAUGCAGCAGGCCAUGUACUUGCCAUGGUGAGGGUCACACUUGACCAUCUGAUUGGCUGGCUCGAAGCGGGCACUGGCGAUCUUGGCCACGGACAGCUGCUCAUGGUAGGCCUUCUUGGCUGAGAUGACCAGGGCGUAGGUGGCCAGGGGGAGGUGGAUGUGGGGGUAUGGCACCAAGUUGGUUUGGAAUUCUGUCAAGUACACAUUCAGGGCCCCAUCGAAUCACAGGGAGGCCGUGAUGGAGGACACGAUCUGCCCAGACGACUGAGGUUGGUGUACAUGGGACACUCGAUGUCCAGGUUGUGCUGACAUGUCAUAGGUGGCUUUGCUGUCGACUAUGAAGGCACAGUCAGAAUGUUCCAGGGUCGUGUAGGUGGUCAGGAUGGAGUUGUAGGGCUCCGUCAUGGCCAUGGAGACCUGGGGGGCUGGGCAAAUGGCAAACUCCAGCUUGGACUUCUUCCCGUAGUCCACCGAGAGCCGCUUCAUGAGCAGAGACACGAACCCAGAGCCAGUGCCGCCCCCAAAGCUGUGGAAGAUGAGGAAGCCCUGCAGUCCCAUGCACAGAUCUGCCUGAGAGAAACCAGACAACGUAAGCCAAUGCCCGUGGGAGCCACACCACCAACCUCCACCAAGCCGGGGCCACUUCUCUUUGCCUCUGAGAGUUGAUACGGAUUCAGACCAUCCAUAAUGAACACGCAUCACACUUUGAAGCAGAGAAAAGCAGACAAUACAGAUCUAUGCACAAAUCACCACGCACACUUCACAGUAAGACGUUGCAGAGGUCUAGGAAGGCUGGUUUGAAGAAAUACACAGAAGAAAAACGGAUGGACUAACCAGAGCGCUCAGCCAGCCUGCUGGACUGGCACCCGUGGCUACAGACACUCUUGUUUAGCACCAUGGAGAGCUCCCUGCACAGAAGCAAGGACUCAGGGCAUUGCCCCCUCUCUACCUGAGAACUAGACUCAGCGCCCAGCACUGGAUUUGAUAAUACAGGUACUCAAAUACAUGUGCUUUCCUCUUUACUCAGACACUUCUAGGGCUGGCAGGGUCAGACAGUAAUCCCCCACUUUGUGGGGAGGCCCUGUUUUUGCUGAACAGCUCAAGGGCAGGAAGAUUCUUUCUUCCACACACCCCUGCAACUGCCAAUACUUGUUCUGUGUGACCCUUGCAGCCAUCCUAUGCGGUAGGUGCUACCAUUGCCAUGGAUCAAGUGGGGACGCACAGAUCCAAGCUCCUUCACCUCUCAAGGGAGUUGGGCCCUCCCACAGAUCUCUUGGAGGAAAAAAAUGGCCUUGCUGGGCCUGUCGAUUUCCAGUCCCCACCCACCUCCCUCAUGUACAUGUGUCUGUUUGUGAAACCUUCAUAGCACCUUAGCUUCCAGGCCCUCCAUCCCGGCUGCCUCUCUGGCACUUGCCCUUUUACUGUGCGGGUCCAAAGAGACACCUAUGUUCAGUUUGUCAAAGUCUGAAAUAAGCCUGUCUUUUAAUUUCAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications