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RNU5F-1: RNU5F-1 is a small nuclear RNA (snRNA) that is downregulated in the AC group [PMC6616969]. It is also one of the five small nuclear RNAs that are modulated in response to certain stimuli [PMC4694891]. Additionally, RNU5F-1 is located in the intron of RNU5F-1 and IARS2, and it has been reported to respond to p53 activation [PMC6120784]. Furthermore, RNU5F-1 has been identified as a sentinel variant or close proxy for lung function-associated loci [PMC4686825]. It is located in a DNase hypersensitivity site and may play a role in lung function [PMC4686825]. Interestingly, Pol II termination is not inevitable at T-runs on RNU5F-1, as shown by extended reads beyond some T-stretches [PMC7610016]. Overall, RNU5F-1 is a downregulated snRNA that may have functional implications in various biological processes.
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