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Homo sapiens (human) lncRNA associated with ovarian cancer 1 (LNCOC1) URS0000759EB7_9606

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LNCOC1: LNCOC1 is a long non-coding RNA (lncRNA) that has been shown to be an oncogene in ovarian cancer [PMC9056108]. In melanoma, the expression levels of LNCOC1 were significantly increased in melanoma cell lines compared to primary human melanocytes, while the expression levels of miR-124 were remarkably decreased [PMC9056108]. Overexpression of LNCOC1 promoted the invasion and migration of melanoma cells, while knockdown of LNCOC1 inhibited these behaviors [PMC9056108]. The expression of LNCOC1 and miR-124 were inversely correlated in both melanoma tissues and non-tumor tissues, suggesting an important regulatory mechanism in the pathogenesis and progression of melanoma [PMC9056108]. miR-124 was found to target LNCOC1 to suppress tumor behaviors in melanoma cells [PMC9056108]. The interaction between miR-124 and LNCOC1 was predicted using bioinformatics analysis, which showed a binding site for miR-124 in the 3'-UTR of LNCOC1 [PMC9056108]. Overexpression of miR-124 led to downregulation of LNCOC1 expression, while overexpression of LNCOC1 did not affect the expression levels of miR-124 [PMC9056108]. High expression levels of LNCOC1 were significantly associated with poor survival in melanoma patients [PMC9056108]. In addition, lncRNAs like LNCOC1 can play a role in tumor progression by regulating transcription factors and signaling pathways involved in invasion and metastasis [PMC9056108][PMID: 33786002][PMID: 33786002][PMID: 33786002][PMID: 33786002][PMID: 33786002][PMID: 33786002][PMID: 33786002][PMID: 33786002][PMID: 33786002][PMID: 33786002][PMID: 33786002].

Genome locations

Gene Ontology annotations

Sequence

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GAAGACGCGGCCUGGCCCUGGCCGUUCGGCCCUUCGUCUGAGCGCAAAGGCUCCAGCACCUCCGCGGCCGAAGCCGCGGGACUUUUCGUGGAAAAUGGGACCCAGCCCGAUCGCCAGCGGCGCUGCAGCGGACUCUGCGGGAACCUAGCUUCUGCUCCAGGACCUCCAGGGCCACCCCAGCUCGCAGGGCGUUCGCAGCGGCUCAGGGCGAAUCACGCUCAUGGUCCCCGUGCGCAUUUUCAGCCCCAGCCGGUCUUUCCAGAGACACAUAGAAGGUGCCAUCUAUGAGGAACAGGCCUUCACCAGACAUCAAAUCUGUUGGCAUCUUGAUCUUUGACUUCUCCACCGCCAGAACUAGAUCAAGACAUGAAACCCAUGUUCAAGAUACUUUCCAGUGUGUCUUCAUGUGAUCCUCUGAGUCCAGCCAUCAGGCUACCAGCAGCUCUUGGAAACCCUGACAUACUUAUUCUUAGAAGACUGCUUUCCGGACUCAAAGUGGAACCUCAAAUUUUCAAUUUUCUUUGUUUUUAAAGCCUACACAUAGGUGAUGAUAUAUACAUGCAUAUAUAUUUUGGAGAAUUUAUAAUUCUGAAAACAAUGCUGGUCUUAUGGAACCCAUCCAUUCCCCUUUCCCCGUGUGUGCUCCGAGCUGUGGUGGCACGUGAAAAGGGGUCCUUCCAGCAGUGGCCCACAGCCCUGGGCUGCUUACUUGCUCACUUCAUUUACAAGAGCAAGAAAUACACAUUCUUGUGUUGUUUAAGUCAUUAUGAUGUGGGGAUUUCCAUUACUCACACACCUGAUCUAGUAGUAACACAGUAGCCUAUUUUAGCAAUAUCAUUUAUUCAAUAAUCCAUUCUUUCCCCAUUAGUUUUGAGCCUUCAUUUAUUGUGUACUAAGUUCUGGUUAUUUUUAGUGGUUGUAAUCUCCUUCUUUCCUACUCUCUUAAUCAUGGGAUUGCCAAUAUCUGCUCUGUGUUUCUGUGCCAUCUAUAGCCUCUGGCCUUGGUACUGCUUCAAAACUGAUAUUUCUAACCUUACUUUGACUUCUCCAUUCAGUGAAGUUCCCAUAGUUCAUCACUCAACUGCUCUCUUUCCAUCGUGACCUUCUGAACUAGCUCACACCCAGAUGUACUUUUGUUAUCUGCCUUUCCCCCUCAUAAACAUGGGCUGCUGCUGGGGAAAAUCCACUACCGAACUCUUGCAGGUCUCUGCAAAUGUUUAAUGCCCUGUCUUAGCCAUGACCUCCACAAUGCUGGGCUAUCCUAUGUUAUGUCCCCUAAGAUAUCCCUUCUCUCUUACCUUUGGGGAUAGUCCUAAGCUUCCAUCAUGGCACUCAAAGUCCAACCUUAUUUGUACCCUCAUUCUCUGAGCAGACACCACCGUAUUCUGUUUCACAGAGAAAAUGUGACUGCUGGGGAUAAUUCUUUCAACUUCCUGGCCUCUUCCUAUACAUGAUCUUUCUCUGUAUUCUUGCCUAUUGCUCUUCCAUGUUGAUAGAAGUGUCUGUUCUCCUUGUCAGUGUCUCGGCCUUGGAUCUGUCCCCUAGACUAUUCUGCCUGUGUAAGGACCUUCCCUGACCAGCUGGGCCACCAUCUCCUGCUUCUCCAAUCCCUCACUCUAGACUGACUCUUAACCUUUGGUCAACAAUACUUGAGCUUUUACAUUCAUAAUGGAGCAUCUGUGUUGAACCUUGUUCUUUUCUAGACACUACCCUCCGUUCUGUCUUCCAUCCAUGGUGACUUUUCUAGAAAGAGCAUCUAUCACACUGGAGACAGCAAACUCCUUGAUCCAUUCUAAUUCCUAACCCUGCAAUAAUUUUCUAUCUCCCUUACUCAAGUAAUUGGGAGUGCUCCUAGUGUUACCAGAGACCCAGCAGUUCCCAAUUUCGAAUUUUUCCGUAUUCACAUUUCUUGACUUGCUAUGAUUUUACAUCACAGAUUACAUCCUUCAUUUGAAGAGACUCUAAUGGAAGGCUGCCAUGGAAACUCUCUCAUGUGGCUGACCUCCUACCUCACUUGCUCUUUCUGAAUGAAGUUCCCACUUUUGCCUGCCUUAAUGAAAGUAAUGCUCCCCAAACUCAAGCCCAGGGCUGCGAAUUGGAAGCAGCUGGGGCUACUGUUUCUGGGUGCUGGUGUGAAUGGCAGGAUGUGAACACCAGCCUGUGACGGGCAAAAAGAUGGACACACAGGCAGAGCCUGACAGGUGCUGGUGGUCCUAUCUGGUCCUGAGUUGCUGGGACCCUCCUUGCCCACUGCCCCUAGAAUGGACUUUGGCCUCAGGUUCGAAGUGUUCAGAUGUGACUGAGAUGAGCCUUUUCCCCAUGCCUCAGGAAUAGCGAAGAAACUCUAUCUGGAAGGUUCCCCAGGCUUCCCCACCCAGCAGCCUCUGGUAUUAGACCAGGCAGUGGCUGGCCAGGAUGGUGGGGACAGAAGGGAGACAAAGGUGAGCAGUGGGUGGGGUCACAUCCUCCCUGACAUUGAAUAGACAACAUGGGGAGGAAGGAUGAGUGAUCUUUAGAAUGUUCAUGGAAAAUGCAUAUUGGGAAAAAGAAUGCAUGAAUUUCAAAUUGUUUUGCAACAAAAUAAACUUGUACUAACUUGUGAAAACACGUCCGAACAGGAUCUAGUUUGAGGCCCUAAGAAGUAUAAGACAACAGUUUGAACAGAGCUCCUAUCAGACACAUGAAUUCUGCUAAAAUUGAAACCAGAACAAACAUGCAAUUGAUGGUGAAGCUUGGCUGGAAACAUGGUGAAAUCAUUGAUGAUUUAUUGAAAGUUUAUAGGGACAAUGCCUCAAAGAAAUCAGCAAUUUAAGUAAGUGGAUAACUCAUUGGAAGAAGAGAAGAGAUGAUGUUGGAGAGGAAGUCCACAGCAGCAGGCCAGCCACAUCAGUCUGUGAGGAAACAAUUCAUCUUGUUUGUGCCCUAAUUUAAGAGGACUGAUUAAUAGCAGCAGAAACAAUAGCCAACGCUGUAGGUAUCCCAAGGUGUUCAGCUUACACAAUUCUGACUGAAAUUAAAGUUGAGUAAACUGUCCACUCGGUGGGUGCCAAAACUUUCUCCCAGCUCAGCUGCAGAUAAGAGAAAAGCGUUCUAUGGCCAUUUUAAACAAGUGGAAUCAAGAUCCUGAAGCAUUUCUUCAUAUAAUUAUAGCCGGAGAUGAAAUGUGGCUUAACCAGUACACUCCUGAAGGCAAAGCACAAGCAAAGCAAUGACUACCUAGAGGUGGGCGUGGUCCCAUCAGAGUAAAAGCAGACAUGUCAAGGGCAAAGGUCGUGGCAACCGUUUUGUGAAUGCUCAAGGCAUCUUGCUUAUUGACUUUCUGGAGGGCCAAAGAACAGUAACAUCUUAUUAUGAGAGUGUAUAGAGAAAGUCAGCCAACGAUUUAGCAGGAAAACACCCAGGAAAUCGUCACCCCGGAAAGCUUCACCAGAGAGCCCUUCUCCACCAUGACAAUGCUCCUGCUCAUUCCUCUCAUCAAACAAGGCCAGUUUUGUGAGAGUUUCAAUGGGAAAUCACUAGGCAUACACCUUCCAGGCCUGAUUUGGUUACUUCUGUUUUAUAAUUUUAAAAAAUCUUUAAAGGGCACCCACUUUUCUUCAGUUAAUAACGUCACAAAGACUGAAGUGGCAUGGUUAAAUUCCCAGGGUGCCCAAUUCUUUAGGGAUGAACUGAAUGGCUGGUACCAUUACUUGCAGAAGCGUCUCGACCUUGAUGGAGCUCAUGCUGAGAAAUAAAACAUUUUUUAAUUUUUAUCUUUUAAUUCAAUUUUUUCGUGAACUUUUGAAGUCCCCUUGUAUUUGUUUUUGGUGGAACUUUGAGUCUGAUUUCUCAGCUCCCCAUGGAUGGCUGCAUCUUAACAGAGAAAUGAACGCCAUUUACCCUGAUGCUCUCUACUUGGCCUAAGUUUCAGAUGUUGAACACACACGUGUGGGAAUUUAUGAAUCUGUGCACCUGUGCCAGCUGGUGGGUGAAGUCUAAGUUUCUUCAACACAAUUAGUUAUCUUCUGCCUCCUGGAAUCUGGUAGGAAAGGUUGAGGAAAAGCAGCCAUCCACAGCGCCUCCACCACUGGAAUGGGGGCAGCCCUAACGUGUGCCCCACUGCCCCCCAUGCUGAGGAGUCCUUCACUCCAGGGAUGUCUUCACCCCAAUCAUUCAGACUCCCCCAGUGUUCCUGCGUCACCUGAAAGGUCGGAAGCAUCUCAGCACAUACUCUCCAUGAGUGGUACUUAGGCCUCCCUCCCCAUCAAUACUGAAGCCCUCAGAGGCAGAGGGGAGUCAAGGAAAAGAGUGGCCAUCAGCAAUAAAUGAGUUACAAGGUUUGAUUUCAAAGAGAAAAACUUGUCACCAAAAUCACUACUCAGGAGAUCUGGACUUCCUCUGAAUGUGAGUUAAAGAACCCUUGAGGGUUAAGAGCCAACUGCACCUGAUCCCCACUCUCCCAUCCCAAGACCCUGGGAAGUCAAACCAAGAGGUAAUCAACAGAAAACAAGUUUAAUGCAACAGGUGACAACGGUCUGGAGCGAGUCCAUGCUCCGGAAGGCUCAGUCUGUGGCAGUCCCGUGGCUCAAGACAGGCUGAGGCCGGCUGCAAUGGAGGCCAGCAGCAGGAGGAUGGCCAGCCACAGCCCACCACAGCUCUCACCCAUGCUCCCAGCAUAUUCUUUGAACACUGAUGAGUUGAUAGGUGGCCCCUCUAAAUUGCAGUAGCGAAUUUUACAACACUUGAGGUAAAAGAAGGGCAUGGGCUCUUCCAGGAGAAACCGCUUCUCCUCUGGCUUGGGUCUCUCCAUCGCUGCACAACCAGCGGAGCACUGCUUCGCAACCAUGAAAAAACGUGGAAAUAUUUCUAAUAGGAAAUAAAGACCGAGAGAAGGCAAUCACGCAAUUCCAAUGCCUGACACCGAGGCCCUUCUGUCUGGGUCAAAGCCUCACCCCUGGCGGCCCUGCUCAAAGGUGCACAGUCAACUGGGGCACCAAGGGGGAGUCGGGAGGACGAGGGCCAGGCCUGUGUGUUGAAUGCUGCUUCAGGGAAGGGCUGGCUUCUGCGUGGUAUGGCCUGUCCAUAUGCACUGGGAAUGCGGGUCUAGGGGUUGCUGUUUGGGAACAAACAGGUCUCAACUUCUCAAACACAGGGUUGGCUCAGGCCUUUGUGACCACAGACAGACACAUGACUCCCAGCCAUUCUGGCCAUCACCCAGGGUGUGGAGCUGGCCUCUUGGUGGGCCUGGCUCGACUCUGAGCUGGGGGUCUUGUCUCAUGACCACACUUCAUCUUAUACAUCACUGUACAAAUCAUUUUGCCAUAUUAAGUUAUAAAGUCGAUGUGGGCCACACUGAGUCUGAAGCAUCACCUCAGCACCCCACCAACUUCGUGGAUACCGAAGGGCUGGAGAGUGACUGCUGGGCGGAAUCAGAAUUCACGAGCCCUGAAGAUCUCCCUGUGGGCAGAAUGUGCUGGGUGUCCAGAUUCCCCUUGGGGAGGGCUUCAUGUACCCAGAGGUUUUCAGGGGAAUCACAGAUGACAGAGCAGUGGUCUCCACAAUUUUUAAGGCAUGCACCCUCCUUUGAGAACACACUUGAAGGCUGUACACCUUGGUUUUGUGCAUCUCUUGUAAGAGUGACAUAGACACUGUUCUCUGUGGCGCAUUUAACACUAUUAAAGCUUAAUUUUUCAUUUAAAAAUGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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