v24

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Homo sapiens (human) VAV3 antisense RNA 1 (VAV3-AS1) URS0000759E9F_9606

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VAV3-AS1: VAV3-AS1 is a noncoding RNA gene that has been implicated in various biological processes and diseases [PMC9614158]. Methylation markers of VAV3-AS1, along with KCNJ12 and EVC, have been shown to be useful for stage and stratification of colorectal cancer (CRC) [PMC9614158]. VAV3-AS1 is associated with the Rap1 signaling pathway and natural killer cell-mediated cytotoxicity [PMC6683893]. One of the CpG sites, cg025848557, is located within intron 1 of VAV3-AS1 [PMC6176894]. Although VAV3-AS1 rs3747945 has not been previously linked to cardiovascular disease outcomes, it supports the role of vasculogenesis in the risk for major adverse cardiovascular events (MACE) [PMC7712544]. Network analysis has revealed an interaction between VAV3-AS1 rs3747945 and NPAS3 rs8008403 [PMC7712544]. VAV3-AS1 codes for an antisense RNA that may regulate the expression of VAV3 [PMC7712544]. Additionally, VAV3-AS1 is one of ten long noncoding RNAs (lncRNAs) that include HOXB–antisense 3 (HOXB-AS3), LGALS8-AS1, LINC00032, LINC00311, LINC00494, LINC00544, LINC00589, LINC00626, MEIS1-AS3, and VAV3-AS1 [PMC7081624].

Genome locations

Gene Ontology annotations

Sequence

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CACCAUCUCCGGACGCAAAGCUUUCGCAUUCAGCUUGAGGAGCUAAACCAUUUCAAGCCAAGGUUUCUUCACAGAUUAGGAUAAAGGAUGAAGAGAAGUAAACUGAAUUACUAAGGAUGCAACAUUAAUGGAGAGAGCCAAGUGAUGUAAAUCGUGGCUGGCCAUGAGUGGAUCUUGAGUGCCAGUUAUCUAGAGAAAUUCCACGUGGCUGUUCCAGGAUGGAUUAGGCACCAAUGACUCUCUUUCACCCUCGAGCUGGAAUCCUGCCCCUUUAACACCUUUCCAGAGAGAGGCAACCCAUGGAGGGUCACAGCAAGAUGGGAUGGUUGUGCCUGGUAGUAAAAAUAUGUAUCACUCUUCAUUUCAUCCAGCUUUGAAGCUUCUGCUAGCAGCUCACACAUGACCCCAAGGGCAGCUCCUCAAGUCUGCUAAAGAAAAGUUAAGUAGAAUUAAUUUUGUUCAAUAUCUCCCAUUUUGUUAGAUUCAUCAUUUUCAGUCAAGAAUGACAAUAUUAAUGGAACCAAAAGAAUAUAUACUAUUAACAUUUCGUCUUAAUUCUACAAAUGUCUAAAAGUCUCUGUAAUUCCCUUAAAAAUAAAAAAAAUGCAAUAUUAAUUUAAAAAAAAAAAAAAA

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Publications