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Homo sapiens (human) USP2 antisense RNA 1 (USP2-AS1) URS0000759D26_9606

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USP2-AS1: USP2-AS1 is a long non-coding RNA (lncRNA) that has been found to play a role in various cancers, including hepatocellular carcinoma (HCC), ovarian cancer, and head and neck squamous cell carcinoma (HNSCC) [PMC7591011] [PMC9174509] [PMC8551278]. In HCC, USP2-AS1 acts as a competing endogenous RNA (ceRNA) to enhance the expression of KIAA1522 by binding with miR-520d-3p [PMC7591011]. Knockdown of USP2-AS1 in HCC cells inhibits cell growth, while overexpression of USP2-AS1 promotes cell proliferation, migration, and invasion [PMC9174509]. USP2-AS1 is also involved in c-Myc-induced E2F1 expression [PMC8551278]. In ovarian cancer, targeting USP2-AS1 may be a potential therapeutic approach [PMC7591011]. In HNSCC, USP2-AS1 is overexpressed and promotes cell proliferation and invasion by regulating DCAF13 activity. Higher levels of USP2-AS1 are associated with poorer overall survival in HNSCC patients [PMC9985331] [PMC9655520]. Furthermore, USP2-AS1 inhibits cellular senescence and functions as an oncogenic lncRNA. Knockdown of USP2-AS1 decreases the binding of G3BP to E2F mRNA. Lentiviruses expressing USP2-AS or specific proteins can be generated using pSin-based constructs in HEK293T cells transfected with pmd.g and pspax. Deletion mutants of USP2-AS can be generated to study its interaction with G3BP using an in vitro binding assay [PMC8551278].

Genome locations

Gene Ontology annotations

Sequence

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GGCCUCCGGCUGGGGCCACCCAGGCAACCGAUAUACACAGAGAACCACGUGGAGGAAAAGCACGCGAGUUUGGAGCGGGUGGAGCAGGAACAGAGGUGGACUGGAAUGUCACACGACGGGGCAGCUGGAAGGGCACCACUGAGUUCAGUACUUCAAAAUUGCCGUGCUCUACCUCUCCCCAGUGCACAAAAACACUCUCCACACCAAGCUGCUGCUGCUGGGGGAUGGAGGGAUGGCGUCAGCGAUUCAAGACUGUUUUUCCUACCUGUUCAGCACUUCUUUCAGCGAUAUGAAGUUAAAUCCAGGCCAAGUUCCCACCUGGUGGGAAGCACUGUGCAGGUUCGUGGGGAUGCAGCCCUGCACAGCCCAGACUGGACUCCUUCCCCAUGGAACUCACAACACACGGGAGAGGCAGAGAGAUCCAAGCGCACAGAAAAACACAAGAAGAUUCAGCCCUGUCAUCUUGUGCAAAUCCUCACUGUCCCCAGAAGGAAGAGAGGCACACAGCGCUCCCCAGCCGCUGGAAUCCAGGAAGAAUUGAGGUGCUCAAGACCCACCACCUCUUUGCCUGCAAACUCUAAGCUCACUGUCCUGCUCCCUUGCUCCCAGAAGUGGCACUGGAUGGAUCCCAUCCAGGUCAGCCCAGGCUGUCAUUUCCUCCCCUUCUGUACCUAAUCUCAGCGAGAUGAAGAGUUUACACCUGUUUCUCACUUGAAUUAGGGAAGUCUAGUUUGCAUUCUCCUGACUGGAUGGGCCUGCAUUGAAUCUUUCAUCUCAUUGGUCUGGGGAUUUGGUUCUGAAGACCAAUGCCUUCCAGAAUCUUCCUGUCUCUCCCCAAAUUCUGGGCGGUUCUGUUUCCAGCACUCAUCCAUGAUGGGGGGGUACAGGAAAUGAGUGUUGAGGGAAAGGCAUCCCACCUUCUCUCUGUUCCAUCUUCCAGAUCUGACAACUCACUGGAAAGUUCUUCUCUGUGUCCCUGUCCCCCGUCUGGUUCUGAGGCCGCUGCUUUCCCCAGCCUUGGUGCCUUGGGUUUUCUGCUCUGUGAAAUGAACCAGGUCCCUUAUCCUGUUCUCCCCUGAAGAAAAGAGGGUGUGGGGGGCUUGGCACAGGAAAUGGCCCUUGCCUUUCACAGGCUUUGGGGUCUGAGGGCAGCUCU

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Publications