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Homo sapiens (human) non-protein coding KCNQ1OT1:2 URS0000759CF4_9606

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KCNQ1OT1: KCNQ1OT1 is a long non-coding RNA (lncRNA) that has been implicated in various aspects of cancer biology, including drug resistance and immune escape in hepatocellular carcinoma (HCC) [PMC7521583]. Downregulation of KCNQ1OT1 expression has been shown to weaken multidrug resistance (MDR) in chordoma cells [PMC7457737]. In sorafenib-resistant HCC cells, KCNQ1OT1 knockdown enhances sorafenib sensitivity, induces apoptosis, and inhibits metastasis by targeting miR-506 [PMC7521583]. The expression levels of KCNQ1OT1, miR-506, and PD-L1 mRNA are dysregulated in sorafenib-resistant HCC tissues and cells [PMC7521583]. Knockdown of KCNQ1OT1 improves sorafenib sensitivity and inhibits immune escape by enhancing the immune surveillance ability of T cells in the HCC/T-cell co-culture model [PMC9428469]. In addition to its role in drug resistance and immune escape, KCNQ1OT1 has also been implicated in other cancer types such as colorectal cancer (CRC), osteosarcoma, melanoma, and retinoblastoma (RB) [PMC8615887] [PMC4751614] [PMC8507267]. In CRC cells, excessive nuclear β-catenin leads to dysregulation of KCNQ1OT1 transcription and the expression of its targeted genes [PMC4751614]. The interaction between β-catenin and KCNQ10T10 is also observed in other cancer types such as lung cancer and osteosarcoma [PMC7851512] [PMC7487100]. These findings provide insights into the molecular mechanisms underlying the role of KCNQ10T10 in drug resistance, immune escape, and tumorigenesis, and may have implications for the development of therapeutic strategies [PMC7521583].

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset 

AGGCAGAACGGUCGCCGCGUCGCCUCAGCACGGACCUCCAGGGAGCUCCUCAGCAAGAUCCUGCCAGGGCGCCCCUCAGCGCGAUUCUGCCGGGGUGCCUCUCAGCGUGGUCCUCCCCGGGGCUCCUCAGCACGAUUCUCCCGGUGCGCCCCUCAGCGCGGUCCUCCUCGGUGCGUCAGUCAUCGUGGUUCUCCCCGGCGCGCCCCUCGGCGCGGUUCUCCUCGGGGCUCCUCAGCGCGGCGCUCUUCUGGGGGCUCCUCGGCGCAGUUCUCCCCGGGGACUCCUCGGCGCCGUUCUCCUCGGGGCACCCGGGGCUUUUCGGCGCGGUUCUCCCCGGGGGUUCUUCGGCGCGGUUGUCCCCGGGGGUUCUUCGGCGCGGUUCUCUCCGGGGGCCUCUCGCCGCGGUUCUGUUCUCCCCGGGGGCUCCUCAGCAUGGUUCUCCUCCGCGCGGUCCUCCCUGGGCCUCCUCAGCGCGGCACUCUCCUGGGGGCUCCUCAGCGCGGCACUCUCCCCGGGGGCUCCUCAGCGCGGCACUCUCCCGGCGGCUCCUCAGUGCGGUUCUCCCAGACUCUCCUCAGCGCGGCCCUCCCCAUCUCUCUGGGAGGGUUUGAACACGGUCAGCACGGACCUGGGCGGACGGCGCGGGACGGGUGAUCACUGGCGUUGCUGAGGUGAGCUGUGUGCCCCGCGGCCGUCCCAGAUCACAGGCGUCAGCAGUGCAGCCUGGCCUGGGCAGUGCGCUCCCAUCUGCACCUUAUGGACAGCGUGGCCAGGGUCGAGGUCCGAGUUCCUGGCCGCGUCCCAAGGAUCGGAUUCCGGGUCUAUAGUUCUCAUGGUGGUUCAGAGUGGGCUGAAUUGGGAUUGGAGUCUGGAAUCCGCAUCGUGGUUCUGAGUCCGCGCUAUUGGGAUGGAAGUUGGGAAUCCAUGUUGUGGUUUUGAGUCAAAGCCCGAAUUGGGACCGGAGUCGGAAAUCCACUUAGUGGUUCUGAGUCAGGGCCCGAAUUAGGAUCGGAGGUGGGAAUCCCCGUUGUGGUUCUGAGUUAGGUAUCCUAGUUGGGAUCAGAAUUCGGGUCUAGGGUCCACAUCCUGGCUGGGAGUUUGCCUGAGUUGGGAUCUGAGUAGUUGGGGUCCCAGUCAGUCCGGGUCUGGAGUCCGCAUGGUGGUUUUAGGUAGGGCCUCAUUAGGGACAGAGGAUCGGGAGUCUGAGUUGGGGACCUGAAUCCCGGUCUGGAGUCUGCAUCAUGGCUCUGAGUUGAGAUCCAAGGGAGGUCCGAGUUGGCGACUGGAGUCAGGGUCUGGAGUCUGUCUUUGGGUAGAGGUUCUGAAUGGGGGGCUCUGAGUUAAGAGAUUGGGAUUGGGGUUAGAGGUCUCAGUGGGGUAUGGGAGUCAGGAAUUGAAGUCGAAGUUCUGCCUCUAGGUGGGGAUUCUGAGUCAGGAAUUAGGGGGCGAAGUAAAGGUUGCAGUCUGAGUUGGGGGUGGUGAUCACCUGCCAGGUGAGAGGUAGUGGUAGAAGUCUCUUGGUCAUAUUGGAGAUGAGAGUUGAUCAGAUGCAGGUCUCAGUCUGGGUAGUAGGCUUGAAGGGCCACCACUAUGUUCAGAUCCCAGUACCCCACUGUGGUCCCUGAGCAGGUCAAAUAGCCUUUUAUAUAAAAUUGAGAGUAAGAGUGCCUUCCCACAGCACUGUUCUGGUUAUGAAAGAGAAUAAUUCAUCCAGGUAGAAUAGUUCUGUCUUAGAUUAUCACAAAGUAUAAAAACUUUCCUGAUAAUAUCCACAUUUGAUGUGCAUUUACCAGUUCUUUCUUUACUGUGGUGCCCCUUUUGCUAGACCAAAAGCUCCCAACGAGGAACUCUGUUUUGUUUUCUGCUGCCUGCUCUGUACCCAGCCAAGAGCCUGAUACACAGCCUUACUCAGUCAGUACUUGAAGGAAAGCAGGCAGGCAGGAUUAACCAGAUUUCUAUGGUGUCUCAAAUGAUCCAUUUCUGCACCUGUUUUCCAGAUACUCAGUAGGAGAAAAAUUUAAGGAUUGAGUUGCUUGAUUAUGGGUGUAUUUUAAUGUGUUUCCUAACAUGCUGAGGAGAAAAGUGGGUCUGUUUCAGGAUUUAUGCUCCAGCUAGAGGGAUUUUUUAAAAUUGCGAAUCAGAGCAUGUCCAAAUUCAGAUAGAAAGCACAAGAAAACUAUAAAGAAUUUCCCUUAUGAAUGUAGAUGCAGAAGUUCCUUGUACAAUGCUAGCUAACUGAAUCCAAUAAUAUGUAUUAAACAACAAUUCUUAAACAAGUGGGAUUGCUCUUAGGAAUGCAAAGAUGAUCCAAUAUCAGAAACUUUAUCCAUGUAAUUCACAUUAAGAGGCUACAGGAGAAAAACCAUAUGGUUCCCUCAAUAGAGGCAGAAAAAAAUGAUGUGAUAAAGUUUAACGCCUAUGUGUGAUUUUGGGGUAGUGGAGUACACCACUUAGCAAGCCAGGACUAGAGAGGAACUUCUUCAACUUGAUACAAGUUAUAAACCAAAACUUAACUUUUCAGUAAACUUGAUAGAGAAAUUAAAAGUGUAUCAUUCUCUUUAAGAUAAGGAGUAGGCCAAGGAUGUCAUCCUGGCCAUACCCUAAUACAAGAAAAAGAAAUGGGGAUGUGAGGAUCAGGUAGGAAGUGAUAAAACUUAGUGUAGCUCAUAGGGUUGAUGGUCUCCAUAAAGAUUCUCAAACAUUUUGGUGUUACGACUUGUUGUAUUCUUAAAAGUUAUUGAAACCCCCAAAGGGCUUUUCUUGAUAGAGAUUCUAUCUGUUGAUAGUUACCAUCUUAGAAGUUAAAACUAAGAAAUGUUUAAAGCAGAACUAUACAAGCACAUAUUCCACUGGGGUCAUGGUGUGCUGCCUCUGGAAAACUCUUUAUCUUUGUGAGAAUGAAAGAAAAGGCAAAUAAUGUCGAGUAUUAUUAUGAAAAUGUUUUUGACCUUUCCUGAAAGGGUCUGGGGGGCUCUCUGGAAUCCCCAGACUACACUUUGAAAAUUACUGGGCUACAUGGAAAAAAAAAAUUAAGGAACUUAACAACUAAAGAGAGAUUUCAGAUUUCAGAGAGGUUUUGGAUAUAAGAUCAGUGUACUCAAAACAAAAAACAAAAACAAACCACAUUUCUUUAUGCCAAUAGCAACUGACUAAAAAAAAGCAUAAUAGAGAUUAGGACAGCAAUCAGAAUAGCAGCAAAAUUUAUACCAGUCUAGGAAUUAACAAAGACGACGACUUUUAUGGAAAAAAUUUUAAAACUCUAUUGGAGGAUAUAGAGGGAGAUCUUUCCAUAUGCAGAGACAUUUUAUUUUCUUGAACAGGGCAACUUGGCAUUAGAAUGACGUCAGGAUUUUCCAAAUCUGUUAAGUUCAACAGGACUCCACUCAAACUUCCAGUUGGAGGGCUUGAGUAAUUUAACAAACAUAUUCUAAAAUGUAUGUGGAAGAAAAAUAUUUGUAAAUGCCAACUGAACUUUUGAAAAGGAGAGCAGAGGACUUCUGCUGGCAGAUACCAGGGCACACGCCAACUUCAGCAAUCAGAGCGGUGUGGUGACAGAGGCCCAGAAGAGAGCUCAGAGGUAACUCCAAGUCUAGAGGAAGGGGACAUGUGAUAAAGGUGGCACCACAUAUCAGUGGGGACUGUUCAGAAGAUGAUGUUGGAAAGCCAGCCCUAAAAUGGAGGAAUAGGAAUAUGGAUUCCUAACUGAGCCCCUAGGAAAAGUAGACUCCAAAUGGACUAAAUAUUUGAAAGCAAAAGGUAGUUGCCAUUUGUUUAAUAGGAGAAAAAAUGAAUAAUCUCCAGGGCCAGGGUGGCCGUGGGGUUCUUAAACAGGAUCCAGAAAGCACAAACCUCAAGACUAAAAUGUAUGAACUUGAAUGCAUUAAUGAUUAUGGAUUAAGGAUUUCUGUUAAAUAAAUCCAUCAUGGCAAGGGUCAAGACUGUUUUCAUAAUAAUACUAAGGAAACAAUUUGCGUUUUUCACUUUUACACUCAUGAAUGUAACUUUGCCAUGACUCAUUACAAGAUAUUUGAAACAAUUAAAGCUGAGGAGGGAACAACAGCUAAAAUAUACCAGAAAGCACCACAAAUCAUUAAGAAAAAGGUAGGAAGAUUGCCAGUUUGCAGGAGGGUUAACAAACAGAUGAAAAUUUGCCCAAGCUAAUCAGUUAUCAGAGAAAUGUAAAUGAAAGCAACAGCUAUUCUUCAUAGGAGAAGCAUUAGAAAGUAGGAUAAGGCCAAGUGUUGGCAGAAGGCAAGGAACAAGCCUCCCUGUGUGCUGCAGGUGGGGACGGAGACAGGCACAGACGUUCUGAAGAGCUGGCCAACACUUCUUCCUCAAAUAAAAUAUUUUAUACCUGUGGCCCAGCAGUUUCCCUCCUAAGUAAACAUGCUGGAGCAGUUCUCACCCAGAACAACGAGAGGCUGUGUGUGUGCAUGCUCAGGGCAGCAUGGCCCAUAGGGGUGGGCAGUUGGAGCUGGUCACUGUGGUUAGGAGCAGGGGACUAGAUGUACACUUCACAAGAUAGAGACGCGUGGAAACACAGUGCUGAGUGACACAAAUGCCAAACAGAAAGAGGGCCUCAGUACAUGACUGUGUAUUUAAAUUAAAAUUACACACCACCCAGACACGCAGUACUAGGGAGUGCUCGUGAGUGCACACACACACACACAAUGAUAUAAAUAAAUUACCCUGGAGAAGCUGUUUGUGUAGGGAGGAGAGCAAGGAUAGAGGCUAGAGAUGAAGUGGAAAAGCAUGGAGAGGAAGAGAGCGGUGACUUUAUGCAGACCCUUACAGGGUGACAGUGUUUCAUAGGCUGAGGGCUGUGAUCAACUCUGUGCAGAGUCCCAAAAGCCAAGAACCAACGAAUGAAUGUGCCUCCAUGACUCUCCUGCCAGAUACCCUCUAGUGGCUUCUAUUUCUAGGAAAUAAAAUUCAAAUUCCAUCAGGUUUUUACAAGAUCUGCCCUGCUUACCUCUCUGACCACUGUCCUCCCUCACUGA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Taxonomic tree

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