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Homo sapiens (human) neuroblastoma associated transcript 1 (NBAT1) URS0000759BF6_9606

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NBAT1: NBAT1 is a tumor suppressor long non-coding RNA (lncRNA) that has been studied in various cancer types, including glioma, neuroblastoma, and breast cancer. In glioma, NBAT1 has been confirmed to play a tumor suppressor role [PMC10094781]. It is also found to be downregulated in high-risk neuroblastomas [PMC8707517]. In breast cancer, NBAT1 exerts its effect through the DKK1 protein, which inhibits the Wnt signaling pathway [PMC5855792]. The expression of NBAT1 can be manipulated in cell lines to study its function. For example, knockdown of lnc-NBAT1 leads to changes in the expression of miR-21-5p and NBAT1 in HEC-1A and Ishikawa cells [PMC9328976]. Overexpression of NBAT1 can restore Sox9 expression in BGC-823 cells [PMC6240717]. Conversely, silencing NBAT1 expression is observed in AGS cells [PMC6240717]. The interaction of NBAT1 with PRC2 is not necessary for guiding its function but rather for repressing its catalytic function [PMC5855792]. Overall, these studies highlight the importance of NBAT1 as a tumor suppressor lncRNA with potential therapeutic implications.

Genome locations

Gene Ontology annotations

Sequence

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CUAGAAUGAGAAUGCACAGCAAGCGGCAGACAAUCACCCGGCAUUCGGCAUCUCUUUCUUUUCACGCGCUCCCUCGCUCCGCCUUUCUCCAGCUCUGCCUUCUCAGGCAGAUACAUCAGAUACCUUGUUUAUCCAUCUUCAGCUCCACUCUGAGGGCGCAGACGCACGAUUCCGGGAUCGGGUGCACCACGGCGAAGCCCAGGCGGGAGACGGCAGGAGCAGCUCAGAUGAAGAAACUGAAACCCACAGAGAUGAAGUAACAUCCUCAAGAUCAAAAGGUAACAAACGAUUGAGGCAGGAUUUGGAUAUUGCUCUACAUGACGGGAAAGCCUGUGCUCUUGGAAUUACAGUCAUAGUACAACAGAUCAAGUUCAAAGCAUCAUCUAAGUCAAGGAAAACCAGUAAAGAGGUUUGGAGAGACAAACAGGGUCAACUCCAGGCAUUUGGGUCAGCAGAAACGGCACGAUUGAGCAGCACUGUGACUAUAGGAUCAUGGAUCAGAGGCUGCUUCCUCUUUGGUUCUGGGCAUCAGCCUCAUGUCCACUCAAAGUAAGUGGCCCCUCUGAUUGGAAUCGGAGGUGCCUGGGUCAUCUCACAGAGCCAAACAAAUACAAUUAGCUAUUGCAAAGCCUUUUGGGAAUUAUUCCCAGUGUAAAUAAACACAUAACCAUAUAGCAAGAGCCUUGAUAAAGUCCAAAAACAUGCAAACUUGGAGUAUCUAAGAGAAAAGACCACAAUGUAAAUGAAAAACCAAAUAAACUCGGGCAAACCAUAGGAUAGGGCCCUGUCUGUGAUGGCCUGCAUAUGAUGAGCCAUAGAAAAAGGAUGGUGAAUUCUGGAUAAUAAGAAAUGUCAAUGAGAUGCAAGAACCACCUGUUUUAUGUAAAGCUCCAAAUAACCAGAUCACAGUGGACAGCCACUCAAAUAAUGCCUUCAUAAUACAGAGUAUUAUUGAGAAUAACUCAGUUCACAGAGAGCUUAAGGCAGCCAAUAUUUGAUAGCCUGUCAGAAAAAAACAGAACAGUAAUUAUAGAAAAGAAUCAUAUCCUCGGAAAAACAAAAAUUAAUCAAACUAAGUUUGUAAAGUCUAUCUUACAGACACAUUGUCUGGACUGGUCCUCUCAAAAAUACUGUUUUUUUUUAAUGCCAAUUUGUUUAGUUAAUGAUUUUUGUCUUAUUACUUCAAAACUGGAAAUAUCCUAUGACUCAUAAUAUCUUACAACCUUUCUACUUUCUUAAAGAAUCUCAAGUUUAUAAUCACAGGGGAUCGGAUUAUUUUUCAAAAAUUAAAUGGUGAUGUAAUGAUUUCUGUGUCUAUUGUAGAAAAGUCAACCUUAUUACAGCUGCAACAAUGGCAUUAAGAAAUAUGAGUAAUUCCAAUCAACUUGAGAUAAUGUCUAAUCAAACACAAAUACAACUGGUAAAUUUCAUUAAAUAGCAUGGAGAUUAAAUUAAAACACUAUUAUGUAAUAAAAACCUUUAGUGGUACUAAAAUUUUAGAAUAGUUCAGAUAUACAGAAAAAUUUCAAAGAUACACAGAGUUCCCAUUUUUUUCCUAUUACUAACCUCUCAUAUUUGUCACAACUAAUGAAUAUUCAAUAGAGUAUUAUUAACUAAAGCCUAUACAUUUAUUUAGAUUUCCUUAGUUUUUAGCUAACAUUCUUUUUCUUUGUUCCAGGAUCCCAUCCGGGCCACCACAUUGAAUUUAUUUGUCAUUUUAGGUACCUCUUGGCUGUGAGUUUCUUAGACUUUCCUUGUUUUUGGUGACCCUGACAGUUUGAGGGAGUACUAGUCAGUCAGUUAUUUUUGCAGAAUGCCCUAAAUUUGAGUUUGGCUGAUGUUUUUCUUAGGGUUUGACUGGGGUUAUGGGUUUUGGGGAGGAAGACCACAGAGGUGAAGUACCAUUCUCACCAAAUUAUAUUAAAGGUACAUACCAUCAGCAUGCCUUAUACUAUUGAUGUGAACUUUGAUUGCCUGGCUGUGGUAGUGUUUGUCAUGUUUCUUCACUGUAAAGUUACUCUUCUCAUCACCCACUUUUCUGUACUGUACUCUUUGGAAGAAAGUCACUAUAUGCAUCCCAAAUUUAAGGAGUGGGAAGUUAUGCUCCACCCAUUUGUAAGCAGAAAAUCUACAUAAUUUGUUUGGCAUUCUUCUGCAUAGGAAAAUCAUCUCACUCUCCCAGUUAUUUAUUUAUUUGAUCUUUUUUUAUAUCAGUAUGGACUCAUGGGUAUUUCUUUUAUACUUUGGGUUAUAAUCCAAUACUAACACAAUAAAGAAAUUUUUAAUGGAGAUGCAAAAAAAAAAAAAA

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Publications