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Homo sapiens (human) p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript (PRECSIT) URS00007599F5_9606

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PRECSIT: PRECSIT is a p53-regulated long non-coding RNA (lncRNA) that is up-regulated in invasive cutaneous squamous cell carcinoma (cSCC), cSCC in situ, and actinic keratosis (AK) in vivo, and it promotes the progression of cSCC through the activation of the STAT3 signaling pathway [PMC9745357] [PMC9406669]. PRECSIT has been shown to increase cSCC cell invasion by regulating the expression of matrix metalloproteinases (MMPs) via STAT3 signaling [PMC9406669]. It has also been identified as a potential therapeutic target in cSCC [PMC7565940]. In addition, PRECSIT has been included in several lncRNA prognostic models and shown to have prognostic value in cutaneous squamous cell carcinoma and pancreatic ductal adenocarcinoma, with its expression associated with worse overall survival in these cancers [PMC9891880] [PMC8762256]. PRECSIT expression is specifically associated with loss of p53, as its expression is suppressed by wild-type p53 and upregulated when p53 is absent or mutated [PMC8466956]. Depletion of PRECSIT inhibits cSCC cell invasion by downregulating STAT3 expression and activation, as well as MMP production [PMC7599158]. Overall, PRECSIT is a recently characterized lncRNA that plays a tumorigenic role in cSCC progression through its involvement in the STAT3 signaling pathway and regulation of MMPs, and it has potential prognostic value in various cancers.

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Gene Ontology annotations

Sequence

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AAACGCCCUCCAGGGUGAUGACUGUGGGAGCAAAACUGACCGGAACCUGGGCGGUGCAUGCACUGUGCACCCUCCUGGUUAACAGCCCCACGGCCCGAGAGCUGUGCUUUACAUGAAUGUCUUCUGUUAAAGCAGCUCGUGUGGCUUCUGCACCCUGGUGGAGCCAACACACGUGCCUGUCACGGAGGUGAGGAGUGAGUGAGUUCUCACCAGCAUUUGACGCUGACCUUCCGGAGACAUGGCGUCCCUGAGAGCCUGCAGCCUGCCAGAGCAGAGAGCCACCCGCUGGCCGUUCUGUUGGAAUUUCGGAGUUCCUGUCUUUCAGGCAACAUCUGCCAAGCGCGGUUUGUGUAAGGAAACCCAUUCUGUCGUGUCUGCCGGGGCCCAGGGCGGCUGCUGUGCGGGAACCAGCUUUUGUGGCCCAUGGAGCAACGACUCAGUCUGGGGCUCGGCUACUCUCCGGCCCGGGGUACUGGCAUUUCCCUGGGGCCCAUGGGGCGAGUGCCCCUAUUUUUCCCAUGAGGCCUCAGCCAAGAGGAGGUUCGGGAAGAAAGGAAAACACAGGUGAGGAGAGAGAAGGGCGGGCAGAGAGGUACCACGCCAUUAGUGCUGAUGGGGAGAGGCGGCUCCAGCCCGGCACUGCUGUCCUUACGAGGCAUGUUUCCUUUUUAUUCGGAGGAAGAGAAGCAGAGGAACACGUCAUGGAGACGGACCGAGUUGAAGGAGCCAGGGAUGGUGACAAGCGGAAGGAAGUGUGUUUUGUCCCCAUCCAGGGAAGCUUUUGUUUCAUGAGACUUACUUGCGCACGUCUGGUAGCUGCCCUGGACAUUCAUGGACUUUCGUUUUCACUCAGAUUUUGUGGUUCACGUGACACAAAGCAUGAGGACAUCACUGGGCGAGAGGGCCAGGUCACCCCACUGCCGAGGGGCACGCCCCAGCUGUGCACCGCUAGAGUGGGCUUGUCCAGUCCUCGGACACGGGGACAGGGUGUGCCCAUCUCAUGUAAGACAUGAAUAAUAGUAGAAAUUUCUGUUGCAUGAGAACUCUCUGCAUUAUCCUCACCAUUUUCCUGUAAGCGUAAAACGUCUAAAACUUUUUUAUGAGCACACUAAUUCCUCACUUAAGGUCGUCAUUAGGUUCUUGGAAAUGGCAACUUUAAACAAAAGGACAGACAGCAGGUCCUCAAAUAACAUUCUUUCCUUCAACAUCAUUUCAUCCUAAGGAGAAAAAAAUGGAUUUUGUUACAUAUCCUGGUUCAUUUCCAAGAACCAGGUGGGCAUAGAAUUGACCAAAGGUGGAGGAGAACAGAUGUGCGGCUCCGUCCUGGCUGUGUGGCUCCGUCCUGUGGACUAAUGCGUGUGGACAGUCAGGAACACUUUCAGGACAAUGUGGGUGGCCUGCCAAUGGGACCUAUUCCAGAGGUCUGAGAAGAAACCGUUGUUUAACCUAGAAUCCUGCUAGGAAUCAAACUAGCUUUGACAGGAAAAGGAAAAAGAAUGAGGACUCUGAACAGGGACAGACUCAGAACAAUUCUUAUCCACUCAUAGUUUAGGAAAUAAUCUUACAGCAUGUGCUCCACCAGGGUCACCAACUGUCCCAAUUUGCUUGGGACUGAAGGUUUGUUUGUUUUUGUUUCUUUGUUUUGAGACAGAGCGUCUCUCUCUGUUACCCAGGCUAGAGUGCAAUGGCGUGAUUUUAGCUCACUACAACCUCCACUUUCCAGGUUCAAGCAAUUCUCCUGUCUCAGCCUCCCUGAGUGGCAGGGAUUACAGGAACCCACCACCAUGCUGGCUAAUUUUUCAAUAUUUAGUAGAGAUGGGGUUUCACCAUGUUGGCCAGGCUGGUCUCGAACUCCUGACCUCAAGUGAUCCACUUGCCUCAGCUCCCAAAGUGCUGGGAUUACAGGCAUGAGCCACCGUGCCCAGCCUACUGAGGGGUUUUUAUGGACAUGGGACUUUUAAUGCUAACACUAGGACAGUCUCUGUCAGACUGAGAUGAUGGUCACUCUUUGGCCAAACACCUCCACCACUGCCCCGCAACAUCCAUAAUAGCAACAGUUUGAGUAAAGACACAAGUACCAUUUGCGGUCCAAAUACUUGAGUGUGUAAACGGUGCAUUGGGUGUGCACAGCGGUACCCAGAAUCUCCAACUAGCUCCUCAUGAGCUGGGUGGGGCAUGCAGGGAAGGAGGCAAAGCUUCCCACCUGUCUGGGGAGGCUGUGGGCUCCACCUCUGCAGACUUUGGUAGGAGACCAGUGUUCAUGCAGUUGUAGUAAUGCACGUGUAGCUUAGGGUUUUUUUGGGACUAAACUAUGGACAAAGCACAGAACUCAGUUGUCUCUGUAGAAAAGGGUGGCCUGUCACCCGGUACCAGGUGAGGGGAGUGUGGCAGUGGCAAGAGCACCUGGUGGUGGCCGAGAGGAGGCACGGAGGAGAGUCAGGGUACCGUGCCCUCAUGGAGUGAGUGCGGAAGACAAAACAACAGACACAGUUGUAAUGACAUUACUUUAUUUGGGGUUAAAUUAGGGUGCACAUCACAGAAAAUCCUCAAACCACAGGGAAUGAAAUGGAAGUUGUUUCUCUCUGGUAAAACAAGUCUGAAAGCUGCAGUGUCAUCAGAUCCACGGCCCUGCAUCUCUGCCACACCCCACCAUGCACCUCCAGUCCUCCCGGCCUGUGGCUUCCAGGGCUCCAGGAACUAGGGAGGGACAGACACUGGGAUCUUCUGCCAUGAAGCAGAGAGGGAUGCUGGGGAAACACAUGGGCACUCGCUGCCACAAGUGCCUCCUGGAAAAGCAAAACCCAAUGCCAUGGCUGCCUCCCUCCGGCAGCACCAGCACGAGUGAGCCAGAUCCUCACCUUUGAUCAUCAAGGCUGAGAGGUAAUAUCUGAGGUCGACAGAUCAAGAAGUAGAGACAAAAGCAAACCAGGCUGGUGGUAAAGAGGAGGAAUGACCGUAAGAUGCCUCUGAAAAGUGGGAAUAUGGGGAAUCUCCUCUUGGUUUCUGGUUGCACAUGUGAAUUUAUUGAAAACUGAAUAUAUUAAGAUGUGAGCUUAGGAGUUGGCAGCCUGUGGCAUGGGGAGGUGUGGGAAGUGGACAGUCUCAGGUCAGGGUGGGCUGGAAAGUGGUGCCACCUCGAGAACAGUAGGUUAACAUCUACCCCCAGUGACGACAUUCAAACCUUCAUCCAGCAUCCACUUCCAGGGGACAUUUUCACAAAAUAUUCACGAGAGCACACAAAAUAUACAAAGGAUGACGAGGGUUGAACAUUGUUGUGACAAAACAUGGGAAGCAACUUAAGUGCCAUCUGUGGGAAACGGUCUAGUGGUGGAGCUGUGGGGCUGUGGGAUACUGUGGGCGGGUGAGAAACGGAGAGGCGUCUCCAAGCAUCAGUGGGAUAAAAUUGCUCUAUCUGUAUUUUCAAAGGAGAAAAAGAACAAGCCCCAAGCUGUGCAUUUACACGGGGACAUGAGUACAUCCAUCUGUAAUGCGUCUGUCACCCCACAACAGGAGGGGUUAGCUGUGCGUGGGGAGAGGGUGAAGAAGGGCUUUUGCCUGGUGCUAGACUGCCUGGGUUCAAAUCCUGCUCCUACUUAGUGCUGUGCAAUUUGGGCAAAAUACCUAAACCUCUCUGUGCCUUCAUUUCCACCUCUCUAAAGCGGGGUCUGUGACAAUGCCCACUCCUCAUUCAUAAGGUGGUGGUGAGGAUUAAAUGAGCUGAUGCCCUCACAAGGUGUUUGUCCAUCAGUGAUAGGGUUUGGCUGUGGCCCCUGUGUCCCCACCCAAAUCUCAUCUUGAAUUGUAAUCCUCAUAAUCCCCACGUGUCGAGGGAGGGAUCCCGUGGGAGGUGAUCAGAUCAUGGGGGUGGUUCCCCCAUGCUGUCCUCAUGAUAAUGAGUGAGUUCUCACGAGAUCUGAUGGUUUUAUAAGGCAGUUUCCCUGCUCUUACACGCUCUCUUUUGCCUGCCGCCAUAUAAGACAUGGCUUUUCCCUUUCCACCAUGAUUGUAAGUUUCCUGAGGCCUCCCCAGUCAUACAGAACUGUGAAUCAAUUUAACCUCUUUCCUUUAUAAAUUGCUCAGUCUGAGGUAGUUCUUUAUAGCAGUAUGAGAAUGAACUAACACAGUAAAUUGGUACUGCGGAGAGUAGAGUAUUGCUAUAAAGAUACCCAAAAUGUGGAAGCAACUAUGGAACUGGGUAACAGACAGAGAUUGGAACAGUUUGGAGGGCUCAGAAAAAAGACAGGAAGAUGUGGGGAAGAUUGGAACAUCCUAGAGACUUGUUGAAUGGUUUUGACCAAAAUGCUGAUAGUGAUGUGGACAAUAAAGUCCAGGCUGCGGUGGUCUCAGAUGGAGAUGAGGAACUUCUUGGGAACUGGAGUAAAGGUCACUCUUGCUACGCUUUAGCAGAGACUGGUGGCAUUUUGCCCCUGCCCUGAGAUCUGUGGAACUUUGAACGUGAGAGAGAUAACCUGAAAUUGGAACACAUGUUUACGAAGAAGCAGAGCAUUAACAUUUGGAAAAUUUGCAGCCUGACAAUAUGAUAGAAAAGAAAAACCCAUUUUCUGGGGAGAAAUUCAAGCUGGCUGCAGAAGUUUGCAUAAGUAACGAGGAGCCAAAGGUUAGUCACCAAGACAAUGGGGAAAAUGUCUCCAGGGCAUGUCAGAGGCUUCGCAGCAGCCCCUCUUAGCACAGGUCUAGGAGGGAAAAAUGGCUUCAUGGGCCAAGUCUAGGGCCCCACUGCUCUGUGCAGCCUCUGGACUGGAUGCCUUCUGUCCUAGCUGCUGCCACUCAAACUCCAGUCGUGGCUAAAAGGGGCCACAUACAGCUCAGGCUGCUGCUUCAGCGGGUGCAAGCCGGAAGCCUGCACAGAAUUCAAGAAUUGAGGUUUGGGAACUUCUGCCUAGAUGUCAGAGGAAGUAUGGAAACAGCUGGCUGUCUAGGCAAAAGUUUGCUGCAAGGGUGGAACCCUCAUGGAGAACGUUAGGGCAGUGAGGAAGGGAAAUAUGGGGCUGUAGCCCCCAUAACAGAGUACCCACUGGGUCACUGCCUAGUGGAGCUGUAAGAAGAGGGCCACCAUCCUCCAGAUCCCAGAAUGUAGUCCCACUGACAGCUUGCACUGUGGCCUGGAAAAGCUGCAGACACUCAAUGCCAGCCCACGAAAGCAGCCAGGAGGGGGGCUGUACCUUACAAAGCCACAGGAGCAGAGCUGCCCAAGACCAUGGGAACCCACCUCUUUCAUAAGCGUGACCUGGAUGUGAGACAUGGAGUCAAAGGAGAUCAUUUGGGAGCUUUAAGAUUUAAUGAUUGCCUCACUGGAUUUUGGACUUACAUGGGGCCUAUAGCCCCUUUGUUUUGGCCAAUUUCUCCCAUUUGAAAUGGAAUCAUUUACCUAAUGCCUGUACGCCCAUUGUAUCUUGGAAGUAACUAACUUGGUUUUGAUUUUACAGGCUCAUAGGUGGAAGGGACUUGCCUUGUCUCAGAUGAGACUUUGGACUUGGACUUUUGAGUUAAGACUUUGGGGGACAGUUGGAAGGGCAUUAUUGUGUUUUGAAAUGGGAGGACAUGAGAUUGGGGAGGGGCCAGGGGCAGAAUGAUAAUGGUUUGGCUGUUUCUCCACCCAAAUCUCAUCUUGAAUUGUAAUCCCCAUAAUCCCCAUAUAUCGAGGGAGGGACAUGUUGGGAGGUGACUGGAUCUUAGGGGUGGUUUCCCCCAGUUGUUCUCAUAGUAAUGAGUUCUCACAAGAUCUGAUGGUUUUAUAAGGCAGUUUUCCCUGCUCUUGCUCGCUCUGUCUUGCCUGCCGCCCUGUAAGACGUGCCUCUUCCCCUUCUGCCAUAAUGGUAAGUUCCUUGAGGCCUCCCCAGCCAUGCAGAGCCAUGAGUCAAUUAAACCUCUUUUCUUUAUAAAUUACCCAGUCUCGGGUAGUAUCUUUACAGCAGUGAGAGAACAGACUAAGACAAUCAGCUUCUAUGUUGUUGGCAGUUUUACCAUGAGCAUGGAUUCCUAUAUUCCUUCUGAAAUUUUCUUUAAAAGUGUAAGCUUAUAUAGAAAGUAUAUUCGACACUCACAACCCUUCCCAGCCAUAAAAGACAGUGGGGUGUGAGUGUGUGGGAUGGGAUGCAGCAAUGGCAGCCCAGUAACAACAGCAGUGCGUGCCGGGAACAGCUCAGCAGCAGGGCAGGUCAGGGCUAACCCAGUUAACUCAAUGCAGGCUCCCUACACCAAGUGAUUUGGUUUGCAAAUAAAUAUUAUUUGUUUCUGUUUUAAUGUGUAAACAGAGCACCUGAAUUACACAGUAAUGUAACUCUGAAAAUUGCUAAAUUUC

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