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Homo sapiens (human) long intergenic non-protein coding RNA 1003 (LINC01003) URS000075996F_9606

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LINC01003: LINC01003 is a long non-coding RNA (lncRNA) that has been studied in various contexts. It is one of the 10 optimized overlapping differentially expressed lncRNAs (DElncRNAs) identified in a study that employed feature selection and optimization algorithms [PMC10091192]. However, its involvement in liver cancer has not been extensively studied [PMC10091192]. In a recent study analyzing cutaneous squamous cell carcinoma (cSCC) samples, LINC01003 was found to have significant functional alterations and was altered in 68% of specimens [PMC10046480]. LINC01003 has also been found to have a better correlation with hsa-miR-126-3p and is highly expressed in liver hepatocellular carcinoma (LIHC) [PMC9530671]. In multiple myeloma, LINC01003 acts as a tumor suppressor genomic element and functions as a sponge of miR-33a-5p to inhibit the development of the disease by downregulating PIM1 expression [PMC9379253] [PMC8431187]. It is also one of the genetically altered candidates identified as significant/candidate driver genes in gene enrichment analysis [PMC9379253]. Additionally, LINC01003 has been found to correlate with Hypophosphatasia and plays an auxiliary predictive role in this condition [PMC8606216] [PMC10060792]. Overall, LINC01003 appears to have diverse roles and associations with various diseases.

Genome locations

Gene Ontology annotations

Sequence

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CGGGCACCCCCGCCCGCCAGGCACGGCCGCGGCUCCUUCCUCUUCCUGCCCGCGGUAGUGGGGGUGGGGCAGGCCUCGGGACACCUGCCUCCGCCGCCGGCCGCCGGCCGCCGUCCUCGCGCGGCUUCCCGGGCGGCUCUGCCCCGACCGUAGACUCCCGGCCCGCUCGCCGCGGCAGGAGCCGUGGUUCCGCGGACCUGGGCGCGCUCUCUCCCUGGCCACUGGGAGACCCCCCGCGGCCUCGCGGGGAAAACCUCGGGACUGCCCCGCGCCCCCGGCCGUCUCUGCGUCGCUCCUUCUCGCCCGCGACCGUGGACUCGUCCUCGCGAGCCUGGGUUGGCGGAAGCUGCGGGGGCCGGGGUCGCACUACUUGGCGCGGAAGGGCCGGCGGUGGGCGGAGGGAUCCCCGUCCGCGGGGUGAGCCGCUGGGCGGAGCCGGGAGGAGCCGCGAGGAUCCGCAGUGGGGAGCCGGGAGGAACCUGGCGCCGGCACCCACCCGCCGCGCCCACGCGUGCCGCGGUCGCUUGUUUCCCGCGGGAGCCCGGCCGCGCUCGGGGGGAGGCGCGCGCGCAGCUGGGGCUGCCUGGGUCUAGGAGCUCCGGAGCCACCGUUUUGUGCCCGUGGAGCCGCGGGGAAGGCGCACGCGCUCGGGUCUUCCCGGCGGGUCGUCCUGCACUUUCUCCCUCUCCGGUACGGACCGCGGCGUUCUGUUUCCAGGCAAAGGAAAAUAAGUCAAAGACUCAGAAGGCAGCCUGAAUCCAGGGCCUGGGAUGCAGGGUUUGCUGGAACGCCAGCCGGUGCGAUCGCGCCCCUGGGAUUCCGCUUAGCCCGCGCGUCCAUUUCCCUGCAUGGUGGACUCAGUAAAGCCGGAUCUGUCCAACGCCUGCAGCGUGGAUGUGGAGGCGGACUAAUCAACUAGUGCUCUGUUAUUAUUUCUACCCAUCCCUUUUCUCCAUGCUAAUUUGCUUAGAACUUUAACAUUGAAUGGACAGCAAAUGUCAUGUUCUGUUUAAUUAUCACUCCUUGACCAUUAUGUUAAUUUCUUUCCCUAACAAGGUGACGCAUUGUUUUAAGUAACAAUGACCAACUCAUCUACUCUUCUUCCAAAUUGUGUAAAUUGAAGGGUAAAAUGUGGGAAAACGCUAAAUUUGAAUGCUAAAUUUGAACAUUUCACACAACAAUAAUUUGAAAUGCUUCUUUGCAAUAUUAUGGCGUUUCGGAACAGAUAAAAAUACUUCAUUUUCAGACAUUUGGUCAACAAAUACUUCUUGGACGUUUAUAUGCAAAGCAAUGCAUGUAACAUUUUCAUUACUUUGCAAGUGUGCUUAUCAGUAAAAGAAUUUUGUUUUAAAUUCUAGCCUUCGUUUAAAUGUAUUUUAGUUACCACAUUGGGAAGAAAAUAAAAUAUUACUAUGUACGGAAAAAAAAAAAAAAAAAA

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Publications