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Homo sapiens (human) MAGI2 antisense RNA 3 (MAGI2-AS3) URS0000759965_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

MAGI2-AS3: MAGI2-AS3 is a long non-coding RNA (lncRNA) that has been studied in various types of cancer, including non-small cell lung cancer (NSCLC), gastric cancer (GC), esophageal cancer, ovarian cancer, hepatocellular carcinoma (HCC), breast cancer, and melanoma. It has been found to play a role in tumor progression and is considered a potential therapeutic target [PMC8756221]. In NSCLC, the downregulation of MAGI2-AS3 is associated with tumor progression and metastasis [PMC8428372]. MAGI2-AS3 has been shown to recruit EZH2 to the HOXB7 promoter, leading to the suppression of HOXB7 expression [PMC7732634]. In esophageal cancer cells, MAGI2-AS3 restoration or HOXB7 silencing has been found to affect radio-resistance [PMC7732634]. In GC cell lines, MAGI2-AS3 has been shown to have an oncogenic role [PMC6920306]. It has also been found that BRD4 can regulate MAGI2-AS3 expression [PMC6920306]. In HCC cells, the expression of COP1 mRNA is positively correlated with MAGI2-AS3 expression [PMC8692692]. MAGI2-AS3 is poorly expressed in ovarian cancer tissues compared with adjacent control tissue [PMC8428372]. FISH technology has shown that MAGI2-AS3 is localized in HCC cells [PMC6807294]. In breast cancer cells, MAGI2-AS3 inhibits invasion and metastasis by sponging miR-374a and miR-374b-5p [PMC7803496][PMC9654199].

Genome locations

Gene Ontology annotations

Sequence

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GAGGCAGGCUGGGUCCGCCUGGCAGCCUACGGGAGGAGGCGGGAGCCGGGAAGGAGGGGAGCCUAGGCCCGGCGUGGGGAGGCCGGCAGGAAGGGCCUCGAGCCCAGUGCGGACCUUUCUUCAGCCUCUGUGCGACCGAGCCGCGCGCCAGGCUCCUGUGCGAGGAGGACGCGCUGACUCCCUCCGACCUGGGCUCCGAUGGAGCAGAAAUAGCGGGACCUGGACUUGUGGCGCGCCUGGUGCCACAUCUCGGGCUCUGCGAGCGUCCUGGCGCGGGAUCCUGCCGUUUGCAUCCAAGAGAGGGGAGGACAGGGGCAAAAGGAUGCAGGGAGGCUGCUGAUUUCCACUGAAGAGCUAAUUUCCUGUGAGACAUUAACAGUGAUUUAAGAAAAAGAUUCCUGUAACUGUAAUGUCUUACAAUAACAGAAUGCAGGAGAGCACAUAUCAAUGAAGAAAAGACAAAAUGUACUUAUCCAUGAAGCUGAGGUUAAGAAACCAGUGUCUUCAAGAGCCAGGGACAGCACUGGGUCUGUGCAGAGUUGAGAGAUGGUGAUGACAUGUGGUUUCCAGCAUUCCUCACCCAGUCCAGGGACACUGUGGGUGUGCCCAGCUUAAGUCCAGUAACUGGAAAUACAAGCCCAAGUUCUGGAGAGUUUGAGCUGCAGAGAUAUAUAUGGGAACACUUUGAAUCUUGACUCAUUGGCCAUAACCAGCAGAGUGGAAAAUACAAGAAGAGAAAAAAACAUUGAACUGCGAUUUUAUAACAUCCUUUACUAGGCAGAGAGAAGAGGAAACACCAGGAAAGAAAACUGUAUUACGAUGUGAAAACUUAAUGUUGAGAAAUUCAGGCAUCUUGGGGUUAGUGAGGAGAAGUUUUAGGGGCUUAGAUUCUUCUAAACACAUGUACAGAAAUGCAUAUUUCAUCUGAUAUCAAAUGGCAUUUAUAGUGCUAAUCUUUACCUCAAGACUUCACAUCUUUUGGUGAUUGCAUCUUUUAGGUUUAUAGCAGCUAAGUUUGCAUGAAAACACCAGGGCUGUUUCAUUUCAGUCAAGAAUUAAUGUUCAUUGAUUGUGCUUCUGCAUUUCAUGUAACUAUUGUAGAAUUUGUUUUAGUUUUAUGAGGGAAUAAUUGUUCCAACUUCUAUAUAACUCAGGAAUUUACUCUCAAACAACACUGUCAAUUAGUUACUUAUCUCUCUGGAAAUGAUCUGGGAACAUGGAGAGGAAAGGGAGGAAGGGGCAAAAUCUGACCACUUAAAUCUAAGCAUAUUAGAUCAUUUUAUGCUAGAAAGUCCUGAAUGAUGUGACUUUCGUUCUUGUAAAACACCUCUUUCCAUAGAUUCAUGGCCCAAACAGUAUAUAAAGAGUGGGGAAGGAACUGCAUUUGCAAAUAGUUCAAAUCAUUGCUCCAUCUUAACUACGCAGUUCACAAAGUGUGAAGAAAUGUGAUCAUCUCAAAAAAGAUAAUGGGGAAAAAAUAUGUUUUGUUCUGUGACUUUAAAGUCUUGCAAUAUUUUACAUAAAUGAUAAUGGGUGCUUUAAUAAGAACUCUUGAUACUUUUGUUAUUGUAUUCAAUAUAUGCAUAUAAUACAACAGGAUGAUAUUGUUUUGGAUUUGGAAAUGUAUUCUUUCUUAUGCAAUCUUAUGCAGUCAUACUGCUUGAAUAUCAUUACCUGAAUUUAUCUUUCUUUUUUUUGUUGUUGUUUUACACUCUACUUAUUUGGUGCCUGUCAGUCUUUUGUCGUCAGUUUAUAUUCUACUAAACUCAAAAAGACAAUCUCAUACCUUUUGUAAUUGUAGGCAUUCUUUACUAGAUUUUUAAAUACACUUCAAAAAUUCAAGUACUUUGAUUUCAUGCCAUCAAGUAGCUGAAUCUAUCCCCCCGUCUCUUUUUAAAUUUAAGUGAGUAGUUCAAUUUCUGUCACUUUCUACUUUGUGAAUUCUAAAUCUUUUAAAACCAUCUUGCCAUUUUUCGUGCACUUACCCUUACAGAAAACUCUGUGAAACACUACUUAUCUCUACUUUUAUGUUUUUAACUCCUUUUUUAUAUUACUAUUCCCUCUGCUUUCUAAAUGCACAUAUUAAUUUGUUCUUUUUAUUCUCUGUAGCUCUUCUCAGUGUAUGAAUUCAGUUUCCCAUCAGUCUCCAUACAAUUAAAAAAAAGUUGAGUAUUCUGUUAUUUUAAUAAGAUAUCUAGUGCCCAUAUUCUAAUUCUGCCCCUUAUUUUUAAUAUAAUUUUAUUGUUGAUUUAAAAUGACAACAGUUUCAAUUCCCAGAAAGUGAAAGGAAACAAAGGAAUAAUAUUAUAGGCUUAAUUUUUAUCAGUGAACUUGUAGGUGAAGAAAAGAUUUGGGGAAGGAAAUGAACAUAUUAUAUUGCAAAAUAGUAAGGAACAAUCAGAUGUGUUUUCUAGUCUCUGGAAAAGCAUGUUUCAAGAAAUUCAAUGAAAAGUUCAUCAUGCUUGCUUAGAUUGUUGAGAAGCAAAAACACUGAUGAACAUUUGGAAGCAAUGAGAAUGUAAUUCUAAUCAUACUCUUUUAAUAAUGUUGCAAAACUCUCCAAACACUACUCUGUGUGGAUGUCUUUCAGAAUAUGAUGAAUACUAGUAGUCUUAUUCUGCCCUUUUCUCUCUAUCACAAUAUAUACAUUCUAUAUUGCAUACACAUAUUUUCCAAAUAUUACAUAUAAUUUCAUGUAAUUUAUAGACCUAUUAAGGCCCAACCAUUUUCUUGGAUAGGGGAUUCUUUAGAAGUCCAGCUUAAAUAAAGCCCGUAUAGAAAGUUUUUUUAAAAUUUAUACAUAAUCACCUAAAGUAACCUUAUCUACUGAACUCUUAGUACAUGCUACUGGAACCUUUUAUCAUGUUUCUUCCUGGCUUGCAUUACAACACUGUUGACAUAUCUCAGCCUUACUUCUAGGCUUCUUUGAGAGCAUGACUCAUGUUUGUAUUCCUCACUGAGGUUGAAUGAAUAAGAGAAACUACAGUAGUAGGAAAAAACAGUACAUGUACAUAUCAAUGAAUAUGAAAGGGUCAAAUGGAUCUAUUAUAGUAAGCACAAAAUCAACUGACACCAGCAAAGUAAACCCAAAAUUUUUAAUGGUAUUUUAAUAGAUCAAGAGGAGCAAGCAGAUUUUUGAGACAGUUGUCUCCUACUUUCUCUAUCACAGGGAGUAAUUUUAAAAGAAAAAUGGAGGGUAAGUUUCUUUAAGAGAAAAUUGUAGUUUAAAACAGGUCAUGGGAUAAUUAGAAAUAAUUUAAUUUCUUUAGAGGAUUUUAAUCUUUCAACUGCUUGCAAUUAGAUCCUAAGGCAAUAAAAGAAUAAGGAGAUUUGGAAAACCAUUGUCUGUAAUCUCUGAAGAAAAGUGGACAUUAGGGGAGUCAGUUGAAAAGCAAAGCUAUCACCAUUUUCUAAAGAGGAAAAAGGUGAACCUCACAAACUAUAGACCAAAAAAAUAGGACAUCGAGAGAAAGAAUAUGAAGCUAGCAUAGGUUCACAAAGAAUGAGUCAAAUCAAACAACAUGCAUUUUUUAUUUAUAAAGCAUGACUUGUUCAUUGUCAAUUCAUGUUAGCUUAAUCAUUAGGCAUUAAUGCCAUCACUGCAAUGCAUAUGUCAGCAAUAAAUAAUCAAAGACCAGGCUUCCAUCAUUCUGUUUAAUAUCUUCAAGUAAUGCUUAAGUUUGCAAAUGCUCUUUUAACACAUUCUCCAUAUGCAGCCUGCCCAGCACUGCACACAAUAGACCUGUUACUUCCCCCUCACGAGCACUCCUAAUAUUUCAUGUGCUCAUCCAAUUGACUUCUCCCACUGGUGCCUCAUAUUGAAUUUGUAGAAUCACACCUGCUCCUUUUUCAAAACUCUUCUGAGUUUUUUCUUAAAUAAUUCACUGACCCCAAAGUUGUCAGAUAUUUGAAGACUACUCGCACAAUUUUAAUAUUAUAAAUGUAUAAUGUAAAUGUAAUUAAGAUUUGUAUAAUGUACGAUGUACUUUGGUAAAUAAAAGUAUGCUGUGAAUAAAUACGUAUGAUACAAUUCAAAAUUUUACAUAAAUAUGUGAUAAAAUUUAGCUCAUAUUCUUUUUUUUUUUCUUUGAGACGGAGUCUCACUCUGUUGCACCCAGGCUAGAGUGCAGCAGCAUGAUCUCAGCUCACUGCAACCUCUACCUCCUGGGUUCAAACAAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGGAUUACAGGUGCCCGCCACCAUGCCCAGCUAAUUUUUUUCUAUUUUUGUUGUUGUUGUUGUUUUUAGUAGAGACGGGGUUUCACCAUGUUGGUCAGGCUGGUCUUGAACUCCUGACCUCAGAUAAUCCACCUGCCUCGGCCUCCCAAAGUUCUGGGAUUACAGACGUGAACCACGGUGCCCGGCCUAGUUCAUGUUCUUUAAGGACAAUUAUGAAUAUUUUUAUGCACUGUUAAUUUUCAUUAAGAUAUUGAUCAAUUAAUAGCUAUAUAUGUUCUAUAAAUUAAUCCUAUCUAGUUUCAAUCUUAAAUUGUUUGCAUAUACCAAUCUAGUUUAUUGUUUGCAUAUAUUUUAUAGUGUAGAGAUUAGGCAUUUUAAUAAAAUUUUAAAAUUUCCAGGACAUACUGUUAAUGACUAUGCUUCCUACUAUAGGCCAUAAUUAAUUUUUUUCUAUUGUCAACAAUAUUUUGGUAGGGAUGAUCAGGAAAUAAGGAAAUGUUUCCUUCAUUUGUUAACAAUAGGUGUUUGGGGAUUUUAAAAUGAAAAUUGAAGAAGUAAAAGACACCAUAUAUUUAGUUUGUUUGAUUUCGUGGCUUCAAGAGUUCAAUAAUUUAUUGAAAUAUUUUACAGACCAAAGAACAACAGAUAUAUUACGUUUAUAAGCCCCCACAUAUUUUAAAGGAUAAUGGUUUAUAUAUGAAAAUUCCCUGAACCUACACUUCAUCAGGAAAAGCUAAAUAAAAGAAGUUUACAUUUCCUAGGACUAAUGGAGAUUUAUUUCCCAGUCCUCUUCUCUGGAGACAAAUGUAGGUCUCUCUUGAAAAGCAGAAAGUUUUGCAUAUGAGGUAUGAUUUAGUGGGCUAGAAACAUCUUUUCCACCCUCCCCAAAAUGUUUCACUAUGUUUUAUCAUACUAUCUGAUAAUUUUGCACUAAAGUUUUCUUUCUGUGUUAAGAAAAUGCAAAUAUCUCUGAAUGGGUCUCUUUGCUUUAGUCAUACUCAUAUGGCUACUACUGAACAAAAUAUGUUCAUUACAGGAUGAAGGGAAUGUUGCCAGCCAGCAAAUCCCUAGAGUUUGCACUACACCAAACGUUGCUUAGCAAUUUCCACGAUUUUCUCAGUCUAAUUUGCAAGAAUCAAGGAGAUGUUUGUGUAUGCUACAUGAAGUUGUAAAAUUGGUAUUUAUUGUAUGUUUCUAUAUCGAAAGCUUUACAAACAAAGGAAAUGGAAAGUUAACAGGUGGAUAUGAUAGUGUGGCACUACUUUAGCUGGAUGGUAAGGGAGAGCUUCUCUUAGGAAGUGUUUUAGGCCAGGACUUGAAUAAUGAACAGUAUCUAGUUGUACAAAAAUCUGGAGGAAAGACUUUUCAGGCCCAGGAGAAAUGAAAAUUCUUUUCAUGCAUACAAGAAUGAAAGUGAAAAUUACCUACUCUAUGUCCUGAAGUGGGAAGUUGGCUUGCCAGAGAGUAGGUAAUUUUCACUUUGAUUCUUUCAUGCCUUCAGUUAUACUACUUCUUAGGUUAGUUCAUAAGGGUUUCCACAAUUUGGUUCCCACUUAAAAUUUAAAACUUCCCUAACCCAUUCCCACCAUAUAUUGUGCUAAUCCAUGCAUAUGUGACUUUGCGUAUGCUGUUUUCAUUGUUUAAUAUUCUUCUCAUGCAUUCGUUCUUUCCUGAUAACGAACUCAUCUUUGAAACUCCCCUUCAAGCAUCCUCUACUUUAGGAGGCCGCUUCUCACUGUCUCCUGCCUACCACCCAUUGAAUUGUUCAAUUUUUAAGCUGCCAUUGUCUUGUGCAGUUGACACAUUUCUUUGCAAUUACUGAUUUACAUGUCUGCUUUUAUCACUGGUGAGGUUCUUUAGGACAGAGACAUUAUUAAUUCAUCUCUGGGCACAUAUGUUCCAACAUAUUAGAAGUACUACAGAGUGCUAUUACUAUGUAGUAUGUAGUAUUAGUAGUAGUUACUCACAAAUCAUUUUUAAAUAAGUGAUUAUAAUAUCUUUUUGUUAUUAUGAUUUAACACAAGAUGGAAUUUAUUUUCAGAAGUUUCCAUGAUAUAUUUGUUCUAUUUAAAAUCCAAUAGCCAUUAGAAUAUUACCAUUAUUUAAUGUAAAACAAUAAAAUAUUAAAUAUGAUCGUUCAUAUUUAAUGCAAACCGAACUCAUGGAAAUAUUGUGUAAAGAUCAAGUAAUUUUUGACAUACAAUUUUAAACUCAACUUUUCAUAUAGCAUACCUUAUGAUAUAUUUUCAGCCUACUUUUAAAUAUGUUGGCAUUGAAAGCCAGUUACUAAUUCGCUGAAUUCAUGAUUUCUUUUUAAGUUAUAGAAGUGGAAUUAUGUUUGAGAUAUUCAUUGCAUUACAUUUACCAGAACUUGAGUUCUUAACAUGGAACCUGAGAGUUUCUCCAAUUCUUAAGUCCCUGGGAGAAAUAGAUUAGCUGGAUGAGGAACUGAGAGGAAAAAUGGUCAGAGAUGUAGCAAGAGUUGGGAAGAAGGAACAAUGAUUUGCUUUCAAGGAGAUUUUUUCAUUGGUCUGUUUUCAGUGACAAACCCACUGCGAUAAUACAUGUAAAGUGAAAACAUUCAGGAAGUUCCCUUAGAAACCUCUUUUCUGGCAGUUCCUAAUUCUACAACAUUGUAUAAGUGAAAUACCAUAGUUACUGUCAUAGUAAAUUGAGCCAAGAGAAACAAGGGAGCAGGAGAAGAAAAGAAUUAAAGAGAGUUUUGUCUUUCAGUCUUCACUCUGUUUCUUCUUGCUUUUACCAGUCAUUCAGGUUUAUAUAAUUUCUUUAGAGAGGCUUCUACUAUGCAGGUCUUCCUUAAAGUCAUUGGUAUUACCUGGCAUGAUAUGUGAGCCUUUAAUAUCAGUCCCUUUAUCUCUUUAUUUUUAAAGUUUAUAUCAGUACAGAGUCCUGGAUUCUUAAUUAAUUUAAUAGGUUAGACUUUAUGCUAAUAUUCUUCAUUUUGAUGCUCAAAUUUUCCAAAAUUUGGCCAGCAGGGUUCCUUAAAGCUGGGUACCUUGCCCUUUCAACAUGUCCCUCUGAUUCUUUAUUUUUAUUUACUUAUUUAUUUAUUUAUUUAUUUAUUUAUUUAUUUAUUUAUUUAGAGACUGAGUCUUGCUCUGUCUCCCAGCCUGGAGUGCAAUGGCACAAUCUUGGCUCACUGCAACCUCUAUCUCCCAGGUUCAAGCAAUUCUCCUCCCUCAGCCUCCCGAGCAACUGGGACUACAGGCAUGUGCAACCAUGCCUGGCUAAUUUUUUUUGUAUUUUUAGUAGAGACAGGCUUUCACCAUGUUGGUCAGGCUGGCCUCGAUCUCCUGACCUCAAAUGAUCCAUCGCCUCGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGCUGCCACACCCAGCCGUCCCUCUCAUUCUUUAAGUACUUCCAUGUUUUCUAAGGUACAAGAUGUUCCAUAUUAUUUUGUUAUUUGUCUUCCCCAGCUCUGAAAUCUGCCUUUCCUUCAAGGAGCCUUGGUUCUUUCUAGUGACAAAUUAUAUUUAGAAAGAAGAUCUGGGUAUUUGACUUGUAUAUUGCUAUUAAUUGGCCAUUGUUUCUAGUCUCUUUCAGUAGACAGAGCUAAGAAAUGUAAAAGGAAAUAUUUGAAUGUAUGUAUAUGUGAUAUAUUAAGUACAUUUAAACAUAUUAAAUUCAUGAGUUCAUACUAAUACUUUCAAUAAGCCACAAUUCCCUUUUCAUGUUUUCGAAGGAAAAAUAUCCAUUGUCUAUAUACAGUGGACAUAGAUAGUAAUAAUACUGAUCUUGAAAAGAGCAGUCUUAAAUAGAUCCCAUUAAUAGUUAAAGAUAACAUAUCUUAGAAUUCUAGAUAUUAGAGAGAUUAUCUAGAGCUGUAAUCUAGAUAUUUUAUAGAUCUUUGCUGUGCUGUUUUGAAUUUGUGUUGGAGUAGAACAAUCAGAUGACAAAAGCUCAUCCCACAUGGAAAAAUCAAAGCAUUCAUUACAGAGAGAAUUUUGAAAUAAAUGCAUAUAUAAAAAAUAUAUAUGCAUAUAUAAUGCAUAUGUAUAUGCAUAUAAAAUAUAUAUAUAUAAAAUGAGGGUUAUAAACAAUGAAGGAAAUAGUGAUACUAUCUAUGUGGGAACAAUACUAGUAUCCUCCCUUUGGAUGAAUACAGUAGCUACAGAUGCAAUUCUGGGGACUCUGUUUAGCAAUAGCUUAACUAUUGCUUGGCUACAAGCAUGGAUAACUUGUUCAAAGAUAAUGAGGAGUUGUAAAUAUUUAAAUAAACAGGAUUUGCAACAUAAAAAAAA

Taxonomic tree

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