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Homo sapiens (human) eosinophil granule ontogeny transcript (EGOT) URS0000757E01_9606

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EGOT: EGOT is a long non-coding RNA (lncRNA) that has been studied in various contexts, including breast cancer, hypoxia/reoxygenation-mediated autophagy, rectal cancer radiosensitivity, ErbB4 expression, paclitaxel response, cervical cancer development, ITPR1 mRNA expression, ovarian cancer prognosis, antiviral pathway regulation, and immune response regulation [PMC6471868] [PMC8200121] [PMC8091867] [PMC7781029] [PMC3268622] [PMC8490721] [PMC7264421] [PMC9831783] [PMC7939569]. In breast cancer cells, lentivirus Flag-MS2bp and lentivirus EGOT MS2bs were cotransfected and harvested after 48 h for further analysis [PMC6471868]. In cultured tubular cells, EGOT upregulation was found to diminish hypoxia/reoxygenation-mediated autophagy through interaction with the RNA-binding protein Hu antigen R (HuR) and regulation of ATG7/16L1 expressions [PMC8200121]. Inhibition of EGOT was shown to enhance rectal cancer radiosensitivity in vivo [PMC8091867]. The expression of ErbB4 was significantly reduced in the miR-211-5p group and increased in the EGOT group compared to the miR-NC group; co-transfection of miR-211-5p and EGOT reversed the effect of miR-211-5p on ErbB4 expression [PMC8091867]. EGOT may act as a clinical biomarker for paclitaxel response and its proper regulation may enhance paclitaxel sensitivity in cancer patients  [PMC6471868]. It is suggested that EGOT is involved in cervical cancer development [PMC7781029]. EGOT overexpression was found to increase ITPR1 mRNA expression [PMC6471868]. EGOT, along with other downregulated lncRNAs, may serve as potential tumor suppressor genes in ovarian cancer [PMC8490721]. EGOT negatively regulates the antiviral pathway [PMC7264421]. Furthermore, EGOT may play a role in immune response regulation to prevent hyperactivation of immune responses [PMC9424846].

Genome locations

Gene Ontology annotations

Sequence

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CAACUUCUGGGCAAGGCAGAGGUGGGUUUGGCUUUUUAAAAAUUUUUUCAGCCUGUCCUCAUGGAACUACAUAUUCUUUUCUAAGAACUUUUCAUCCUAACCUCCCUACUCACAUCUUCUAAGUGUCUCUGCUCUGGUGGGAAUGUGAUGGACAACACAGAGCCAUCUCAGAAGCCUCUGUGGCCACCACCAGGCCGGCCAGGGUGCAGGGGGCCACUCCCUGGGCAGCCAUAGGGUUCUCAGCAAGGUGCAUUCGUCGUCCCUGCUGAGAAUCUGAUGGGGCAGCAUUUUUUUUUUUAAUUAAAUGCAAGCUGAGUCAUUUCAACCUGCAACCUUCAGGUAACAGGAGUUACCCAAGCUCCAGGAAUUAUGAUUGUGGGGUAAACCCAUUCUCUUGUUUUCUUGCGGUUCUAUUUUAUAACGCACUAGAGGAGACAGAGACGUCAUUGCUUCACCCAGGGCAAGAGGACAAAGGAGGAUGCAUGGAAAUACAAACAGCCCUUCUCCUCCAGGCCAUACCGACUGUCCAACUAGCAACAGACUUCACCUGGUUUUGGAGCAAUCUGAAUUUGGAAUAUGCCAGAGAAAACUUCUAUCAGGCAAGAUGGAAGACUCCUAGGAUAGGUCUCUCUCAUGGAGGGAUUGGCACGAUGGUAAGAGUCCAGUGGAUGGAAAAGGCCUCCUCCUUAAAGAUGGUGAUGGAAACGAGCACUGCACAGGGAAACACAAAUCAGGUCCCCUGAAAUCCAGCCCAACCUGGCCAGACCCUCCAGUGCCCAUCAGGGCUUAUGAACAGGGUGCUUCAGUGUCUUUGUUAGGGGUGGUUAAAAAGGAGCACGUGCUUAUAGGGGAUGCUGCUGAGCUCCAUGAUUUUGACUUCCUGUCUAACCUGUUGAUGCUACAAAACUCUUUUAAAAACAGUUACCAUGGGAACUUUUCCCUAGCAAGCAUUCUUCAAGAAACGUUACAGGUGCUGGUGAAUUCAAUGCCCUUGGUGUCAAUAAGCUUUUGCUGAGUCUUAGAAUGUGUGGCUUGAACUGAGAGGACUUUCAAACAGAUAAUGCGAAGUUUCCAAUGCAAAUGUCUUCGGGGUUAAGUGUCAGUGAAGUGCAGUGGAAGGUAGGGGGAUAAAAUGAUCUCAGUGUAUAUGGAGGCCCCACUUAAGCAUUCAAAAAAUUCUAUAUACAGUGUUUUCAAUGUAUUAUGUAUCAGCAAAACAAAAUACCCCAUAGGGCUAUAAUCAGCUCAGGGGGUCACCUCAGCAAGAGAUGCUCUGGCUAUCACUCCUACUACGGGAUUUCCUCUCUCAUCAGAACCAGUAGGUGGUCAAAACCACAAUAAUGCAUAAAUGAAGGCAGGGAAUUGGGUAUCCAAUGUGAGCAACUGAAAAGGUGCCAUGUAUUAGCUAUUUGCCAUUAUGGUUCUGCAAGUGCUCAGAUGACUCAUAAAAUGACCAGAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications