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Homo sapiens (human) HOXA11 antisense RNA (HOXA11-AS) URS00007333DC_9606

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HOXA11-AS: HOXA11-AS is a long non-coding RNA that is up-regulated in cutaneous melanoma tissues and cells [PMC7866956]. It has been observed that there is a negative relationship between HOXA11-AS and miR-152-3p expression in melanoma tissues [PMC7866956]. HOXA11-AS acts as a sponge for miR-152-3p, regulating the cellular processes of melanoma [PMC7866956]. This suggests that HOXA11-AS is involved in the regulation of melanoma progression through its interaction with miR-152-3p [PMC7866956]. Additionally, HOXA11-AS has been shown to promote the proliferation and invasion of uveal melanoma cells by competitively binding to miR-124 [PMC7604026]. In cutaneous melanoma cells, HOXA11-AS regulates proliferation, apoptosis, metastasis, and epithelial-mesenchymal transition (EMT) by targeting the miR-195-5p/ITGA9 axis [PMC7866956]. The dysregulation of HOXA11-AS and miR152-p suggests their crucial roles in melanoma development [PMC7866956]. Silencing HOXA11-A has been shown to inhibit the proliferation of melanoma cells in vivo by down-regulating pro-proliferation proteins such as PCNA and cyclinD1 [PMC7866956]. In glioma cells, HOXA11-A regulates sensitivity to reactive oxygen species (ROS) through the Tpl2-MEK1/2ERK1/2 pathway [PMC9646708]. HOXB13 has been identified as an upstream regulator of HOXA11-A in prostate cancer cells, where it positively regulates its expression and cooperates with it to promote bone metastasis through CCL2/CCR2 signaling pathway [PMC7912412].

Genome locations

Gene Ontology annotations

Sequence

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GCCACCUCAGGGGAAGCAACAGAUCGUCACUCGGUGUUCUCACCGAAAGCACGUAAUCGCCGGUGUAACUCAUGUUGGCUGGGGGGCCUCCCGGCGCGCGCGGAGAGGCUGGGGUGCGCCCCCAUGCAGCAUGCUUGUGCUCAAUUGCAGGGUCCUCGUUCUCGAGUGUGCAGAGGGCGGUGAGAGCUCAACUCUCGUCCCCACCUCCCACCCGCAGCUCCCCGGGUGGGUGAGGGAUGCCCUGGACUGGGGAUAGCCAGGUGGGAGUCCGUCGCUGUGUGGCCUGUGGUCUCGGAGUCUGUUCUCCUGGAGUCUCGCAUUUGCACCCCCUUCUUCGCAGUCCCCCUCCCAUAGACUUGCUCUGGGAAGCGCCUCUGCCUCCGACCCUAGCCGGAACCCCUUCGGGGCCAGAGUUUGAAGCCGUGGAUGUGCCUGCCUGGUGGCUUGUCCGAUUUGCACGGUGACUUGAUUACACUCUCUCAUUCAUGGUCACUUCCGAAGCGCUUUAGUGCCUUCCGUCCCUAAACCGCCAACAGCCAGAACGGCUUCUCCCCGCGGUUUGUCACUGAUCCGCAGGGCCCGGAAGGGCCUUCGUCUUACCCGGGAUCCACCUCUCCCCUCAUCUUCCCUGCCUACCUCUUCAUCCCACCUUCUGUCCUUGGAGAAACUCCCUCCUCCUCGCUGCCUGCCGGGCUUCGGAGUGACUCGGCAGAGACAGAGGCACAGGGGCUGCCCUGCUGCUCACCGGUCCACCCAUCUGCCUGGUCUUCUGGAGCUGAGGACUCGGGAAACCAUGCAAUUGAGGCAAGCCUUGGGCUGCUUUAGAGGCGCUGACAUCCGAGGAGACUUCUCCUGGGAGGUCCAACAGCCGAGCUUAGCCCACCGGGCUCUGGGAAAGACCCGACUGAGGCUAAAGCCGCCCCGGAAGGCCAAGUCCGAGUUCCAUUUCUUGAAGAGGCCGGCGCGCGUAAGGCUGUGACAUUGGCCCUGGCGACUGGCUUCCCAGGAGCUGUUCUUUCUCAGGAGCUCCACAGCGCGGGCCAUCUCCAGAAAACUGUCUUCAGAGUGUAUUUCCUUUUAUCGUCAACCCAGAGCCCCACCGCGGCUAAUGCAAGAGGCCAAAAAAUGUUUGGAGGAAGAAAAACAAAGGCAGGAAGUGGCGGCGGCCUGACGGUGCGUGUGUGUCUGCAGAGAAGGGAGGGAGCCGGCUCAGUCUCUUCUUGUUUUUCCAAACUUCAAGGUCCAGGCAGCCCUCUGCAGGGCCGGGCCCCAUUGCUCCCCGCGCGGCAUUGGAGGUGGCCGCCCGGAGAGGAGAAGGCCAACGCCUGCGCCAGGCUUGUCAGGCGGAAACGGCUAACAAGGAGAUUUGGUCAGCAAAACAGACCCAGCCUUUCCGAGGCUUCGUCUGACUUGGCCCGAAAGGUUGGGGAGGGGGGGCUUGCGCAGAGCCUCAGGGACCCUCCUCUCUGGGGACUACCAUCCCUGAGCCUUACGCUUCUUUCCACAGCCUUUGCAGGCGGAAUAUCGGAAUAAAGUGGGUCCAGGCGCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications